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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Ischemic Stroke
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Total 2464 results found since Jan 2013.
Racial and Gender Differences in Stroke Severity, Outcomes, and Treatment in Patients with Acute Ischemic Stroke
Background: Previous research has indicated that women and blacks have worse outcomes after acute ischemic stroke (AIS). Little research has been done to investigate the combined influence of race and gender in the presentation, treatment, and outcome of patients with AIS. We sought to determine the association of race and gender on initial stroke severity, thrombolysis, and functional outcome after AIS.Methods: AIS patients who presented to 2 academic medical centers in the United States (2004-2011) were identified through prospective registries. In-hospital strokes were excluded. Stroke severity, measured by admission Na...
Source: Journal of Stroke and Cerebrovascular Diseases - January 27, 2014 Category: Neurology Authors: Amelia K. Boehme, James E. Siegler, Michael T. Mullen, Karen C. Albright, Michael J. Lyerly, Dominique J. Monlezun, Erica M. Jones, Rikki Tanner, Nicole R. Gonzales, T. Mark Beasley, James C. Grotta, Sean I. Savitz, Sheryl Martin-Schild Tags: Original Articles Source Type: research
Does Modern Ischemic Stroke Therapy in a Large Community-based Dedicated Stroke Center Improve Clinical Outcomes? A Two-Year Retrospective Study
Background: To compare modern endovascular therapies in the acute ischemic stroke patients leading to more comprehensive acute stroke algorithm.Methods: A 2-year retrospective nonrandomized study on 76 patients who were placed into 5 different treatment groups for acute ischemic stroke. These groups included: group 1 (no treatment) (n = 24), group 2 (intravenous tissue plasminogen activator [tPA] only) (n = 18), group 3 (intra-arterial [IA] tPA) (n = 9), group 4 (Mechanical Embolus Removal in Cerebral Ischemia [MERCI]; retrieval only) (n = 17), and group 5 (combined IA/MERCI) (n = 8). Age range for all groups was 29-92 yea...
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2013 Category: Neurology Authors: Matthew H. Berlet, Glenn W. Stambo, Merle Kelley, Kelly Van Epps, Troy Woeste, Diana Steffen Tags: Original Articles Source Type: research
Atrial Fibrillation and Paroxysmal Atrial Fibrillation Detection in Patients with Acute Ischemic Stroke
Conclusions: AF/PAF was one of the common causes of ischemic stroke in Thai patients. Most PAF was detected by continuous ECG monitoring. Snapshot 12-lead ECG and continuous ECG monitoring should be recommended in all patients with acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2013 Category: Neurology Authors: Panee Sutamnartpong, Pornpatr A. Dharmasaroja, Disya Ratanakorn, IngOrn Arunakul Tags: Original Articles Source Type: research
Mechanism of Acute Ischemic Stroke in Patients with Severe Middle Cerebral Artery Atherosclerotic Disease
Conclusions: In patients with severe MCA ICAD, the mechanism of stroke is multifactorial, but hemodynamic insufficiency plays a significant role. This finding is important in selecting a subgroup of patients who may benefit from revascularization.
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2014 Category: Neurology Authors: Jordan S. Dubow, Elliott Salamon, Edward Greenberg, Athos Patsalides Tags: Original Articles Source Type: research
A Matched Comparison of Eptifibatide Plus rt-PA Versus rt-PA Alone in Acute Ischemic Stroke
Conclusions: The safety and direction of effect of eptifibatide plus rt-PA were confirmed. A phase III trial is needed to determine the efficacy of eptifibatide plus rt-PA for improving long-term outcomes after AIS.
Source: Journal of Stroke and Cerebrovascular Diseases - February 19, 2014 Category: Neurology Authors: Opeolu Adeoye, William A. Knight, Jane Khoury, Pamela A. Schmit, Heidi Sucharew, Joseph P. Broderick, Arthur M. Pancioli, CLEAR-ER Investigators Tags: Original Articles Source Type: research
Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats
Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin (AAT), a serine proteinase inhibitor with potent anti-inflammatory, anti-apoptotic, antimicrobial, and cytoprotective activities, could be beneficial in stroke. The goal of this study is to test whether AAT can improve ischemic stroke outcome in an established rat model. Middle cerebral artery occlusion was induced in male rats via intracranial (i.c.) microinjection of endothelin-1. Five to 10 minutes after...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Huong L. Moldthan, Aaron C. Hirko, Jeffrey S. Thinschmidt, Maria B. Grant, Zhimin Li, Joanna Peris, Yuanqing Lu, Ahmed S. Elshikha, Michael A. King, Jeffrey A. Hughes, Sihong Song Tags: Original Articles Source Type: research
Characteristics of Wake-up Stroke
Conclusions: WUS is more likely to result from small-vessel disease mechanism. Poorer cholesterol profile and frequent snoring may contribute to WUS.
Source: Journal of Stroke and Cerebrovascular Diseases - December 20, 2013 Category: Neurology Authors: Aki Tanimoto, Prachi Mehndiratta, Brian B. Koo Tags: Original Articles Source Type: research
Intracranial Atherosclerosis in Chinese Young Adult Stroke Patients
Background: Until now, intracranial atherosclerosis has been less well studied because of its rarity. We sought to investigate the prevalence and risk factors of intracranial atherosclerosis in Chinese young adult stroke patients.Methods: We retrospectively reviewed the medical records of consecutive young adult patients with first-ever ischemic stroke at our institution from May 2007 to May 2012. The demographic features and risk factors of intracranial large-artery atherosclerotic (LAA) stroke were analyzed by comparison with other stroke subtypes.Results: One hundred ninety-seven patients (age 39 ± 9 years, 127 male...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Jing-Wen Niu, Shan Gao, Li-Ying Cui, Bin Peng, Yi-Cheng Zhu, Jun Ni, Li-Xin Zhou, Ming Yao, Wei-Hai Xu Tags: Original Articles Source Type: research
Impact of Thyroid Autoantibodies on Functional Outcome in Patients with Acute Ischemic Stroke
Conclusions: This study showed that elevated thyroid autoantibodies were independently associated with unfavorable outcome in patients with acute ischemic stroke. We speculate that immune-mediated vascular damage may contribute to the increased risk of unfavorable outcome by providing insufficient cerebral blood flow to the ischemic area.
Source: Journal of Stroke and Cerebrovascular Diseases - May 5, 2014 Category: Neurology Authors: Han-Jin Cho, Sang-Soo Kim, Sang-Min Sung, Dae-Soo Jung Tags: Original Articles Source Type: research
A Comparative Study of Dual versus Monoantiplatelet Therapy in Patients with Acute Large-Artery Atherosclerosis Stroke
Background: Antiplatelet drugs are recommended for patients with acute noncardioembolic stroke. However, few randomized clinical trials have investigated the safety and efficacy of dual antiplatelet therapy for these patients. The aim of this study was to evaluate the effects of treatment with clopidogrel and aspirin (combination therapy) and aspirin alone (monotherapy) on neurologic deterioration, platelet activation, and other short-term outcomes in patients with acute large-artery atherosclerosis stroke.Materials and Methods: Altogether 574 patients with acute (≤2 days) large-artery atherosclerosis stroke were random...
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2014 Category: Neurology Authors: Xingyang Yi, Jing Lin, Chun Wang, Biao Zhang, Wanzhang Chi Tags: Original Articles Source Type: research
The L-arginine Pathway in Acute Ischemic Stroke and Severe Carotid Stenosis: Temporal Profiles and Association with Biomarkers and Outcome
Conclusions: Metabolites of the L-arginine pathway were elevated in the very acute phase of ischemic stroke indicating a more pronounced endothelial dysfunction compared with AsCS. An increased basal L-arginine level in patients with AIS might be an adaptive mechanism; such transient elevation of the L-arginine/ADMA ratio at 24 poststroke hours may suggest that a temporary increase of L-arginine along with decrease of ADMA might be related to the protective role of L-arginine. Changes in the L-arginine pathway are predictive of poststroke infections.
Source: Journal of Stroke and Cerebrovascular Diseases - July 14, 2014 Category: Neurology Authors: Tihamer Molnar, Gabriella Pusch, Viktoria Papp, Gergely Feher, Laszlo Szapary, Bernadett Biri, Lajos Nagy, Sandor Keki, Zsolt Illes Tags: Original Articles Source Type: research
The Quality of Prehospital Ischemic Stroke Care: Compliance with Guidelines and Impact on In-hospital Stroke Response
This study examined performance measure compliance among EMS-transported stroke patients and the relationship between compliance and in-hospital stroke response.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2014 Category: Neurology Authors: John Adam Oostema, Mojdeh Nasiri, Todd Chassee, Mathew J. Reeves Source Type: research
Heart Rate as a Predictor of Stroke in High-risk, Hypertensive Patients with Previous Stroke or Transient Ischemic Attack
Risk factors for first stroke are well established, but less is known about risk factors for recurrent stroke. In the present analysis, we aimed to assess the effect of heart rate and other possible predictors of stroke in a hypertensive population with previous stroke or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2014 Category: Neurology Authors: Else Charlotte Sandset, Eivind Berge, Sverre E. Kjeldsen, Stevo Julius, Björn Holzhauer, Lars-Henrik Krarup, Tsushung A. Hua Source Type: research
Novel Inflammatory Biomarkers and Their Correlation to Titres in Acute Ischemic Stroke
Young stroke patients constitute 15%-30% of all stroke patients in India as against 3.0%-8.5% reported from the West. The mechanisms for stroke in the young may include unconventional risk factors such as infections. We aimed to investigate the role (if any) of Chlamydia pneumoniae antibodies in young patients with acute ischemic stroke (AIS). Several proinflammatory cytokines and biomarkers are released early after the onset of brain ischemia. We assessed the role of heat shock protein (hsp) 65, neopterin, and myeloperoxidase upregulation after AIS in predicting stroke severity.
Source: Journal of Stroke and Cerebrovascular Diseases - October 1, 2014 Category: Neurology Authors: M.V. Padma Srivastava, Ashu Bhasin, Rama Chaudhry, Sakshi Sharma, Vivekanandhan Subbaiah, Rohit Bhatia, Manjari Tripathi Tags: Original Article Source Type: research
The Obesity Paradox and Survivors of Ischemic Stroke
Although obesity is a risk factor for stroke and achieving normal weight is advocated to decrease stroke risk, the risk associated with obesity and weight loss after stroke has not been well established. The aim of this study was to assess the association of obesity at the time of stroke admission and weight loss after stroke with total mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2015 Category: Neurology Authors: Peter Wohlfahrt, Francisco Lopez-Jimenez, Alena Krajcoviechova, Marie Jozifova, Otto Mayer, Jiri Vanek, Jan Filipovsky, Ernesto M. Llano, Renata Cifkova Source Type: research
