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Source: Circulation
Condition: Ischemic Stroke
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Total 235 results found since Jan 2013.
Thrombus Aspiration in ST Elevation Myocardial Infarction: An Individual Patient Meta-analysis.
CONCLUSIONS: -Routine thrombus aspiration during STEMI PCI did not improve clinical outcomes. In the high thrombus burden subgroup the trends toward reduced CV death and increased stroke or TIA provide a rationale for future trials of improved thrombus aspiration technologies in this high-risk subgroup. Clinical Trial Registration-ClinicalTrials.gov identifier NCT02552407, PROSPERO CRD42015025936.
PMID: 27941066 [PubMed - as supplied by publisher]
Source: Circulation - December 8, 2016 Category: Cardiology Authors: Jolly SS, James SK, Džavík V, Cairns JA, Mahmoud KD, Zijlstra F, Yusuf S, Olivecrona GK, Renlund H, Gao P, Lagerqvist B, Alazzoni A, Kedev S, Stankovic G, Meeks B, Frøbert O Tags: Circulation Source Type: research
Impact of Left Atrial Appendage Closure During Cardiac Surgery on the Occurrence of Early Postoperative Atrial Fibrillation, Stroke, and Mortality: A Propensity Score Matched Analysis of 10,633 Patients.
CONCLUSIONS: -After adjustment for treatment allocation bias, LAA closure during routine cardiac surgery was significantly associated with an increased risk of early POAF, but did not influence the risk of stroke or mortality. It remains uncertain whether prophylactic exclusion of the LAA is warranted for stroke prevention during non-AF-related cardiac surgery.
PMID: 27903589 [PubMed - as supplied by publisher]
Source: Circulation - November 29, 2016 Category: Cardiology Authors: Melduni RM, Schaff HV, Lee HC, Gersh BJ, Noseworthy PA, Bailey KR, Ammash NM, Cha SS, Fatema K, Wysokinski WE, Seward JB, Packer DL, Rihal CS, Asirvatham SJ Tags: Circulation Source Type: research
Incident Type 2 Myocardial Infarction in a Cohort of Patients Undergoing Coronary or Peripheral Arterial Angiography.
CONCLUSIONS: -T2MI is common and associated with poor prognosis. Studies evaluating treatment strategies for management of T2MI are needed.Clinical Trial Registration -https://clinicaltrials.gov/ct2/show/NCT00842868, Clinical Trials.Gov # NCT00842868.
PMID: 27881568 [PubMed - as supplied by publisher]
Source: Circulation - November 20, 2016 Category: Cardiology Authors: Gaggin HK, Liu Y, Lyass A, van Kimmenade RR, Motiwala SR, Kelly N, Mallick A, Gandhi PU, Ibrahim NE, Simon M, Bhardwaj A, Belcher A, Harisiades JE, Massaro JM, D'Agostino RB, Januzzi JL Tags: Circulation Source Type: research
Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients: An APEX Trial Substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban).
CONCLUSIONS: -Among hospitalized medically ill patients, extended-duration betrixaban significantly reduced all-cause stroke and ischemic stroke through 77 days of follow-up Clinical Trial Registration-URL: https://www.clinicaltrials.gov. Unique identifier: NCT01583218.
PMID: 27881569 [PubMed - as supplied by publisher]
Source: Circulation - November 13, 2016 Category: Cardiology Authors: Gibson CM, Chi G, Halaby R, Korjian S, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Gold A, Bandman O, Harrington RA, Cohen AT, APEX Investigators Tags: Circulation Source Type: research
Response by Menon et al to Letter Regarding Article, "Analysis of Workflow and Time to Treatment on Thrombectomy Outcome in the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) Randomized, Controlled Trial".
PMID: 27821426 [PubMed - in process]
Source: Circulation - November 7, 2016 Category: Cardiology Authors: Menon BK, Hill MD, Goyal M Tags: Circulation Source Type: research
Letter by Venema et al Regarding Article, "Analysis of Workflow and Time to Treatment on Thrombectomy Outcome in the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) Randomized, Controlled Trial".
PMID: 27821425 [PubMed - in process]
Source: Circulation - November 7, 2016 Category: Cardiology Authors: Venema E, Lingsma HF, Dippel DW Tags: Circulation Source Type: research
"Weekend Effect" or "Saturday Effect"? An Analysis of Hospital Mortality for Patients With Ischemic Stroke in South Carolina.
PMID: 27821424 [PubMed - in process]
Source: Circulation - November 7, 2016 Category: Cardiology Authors: Shi L, Zhang D, Chen L, Truong KD Tags: Circulation Source Type: research
Treatment with TPA in the "Golden Hour" and the Shape of the 4.5 Hour Time-Benefit Curve in the National US Get With The Guidelines-Stroke Population.
CONCLUSIONS: -Thrombolysis started within the first 60 minutes after onset is associated with best outcomes for patients with acute ischemic stroke, and benefit declined more rapidly early after onset for ability to be discharged home. These findings support intensive efforts to organize stroke systems of care to improve the timeliness of thrombolytic therapy in acute ischemic stroke.
PMID: 27815374 [PubMed - as supplied by publisher]
Source: Circulation - November 3, 2016 Category: Cardiology Authors: Kim JT, Fonarow GC, Smith EE, Reeves MJ, Navalkele DD, Grotta JC, Grau-Sepulveda MV, Hernandez AF, Peterson ED, Schwamm LH, Saver JL Tags: Circulation Source Type: research
Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-analysis.
CONCLUSIONS: -Carriers of CYP2C19 loss-of-function alleles are at greater risk of stroke and composite vascular events compared with non-carriers among patients with ischemic stroke or TIA treated with clopidogrel.
PMID: 27806998 [PubMed - as supplied by publisher]
Source: Circulation - November 1, 2016 Category: Cardiology Authors: Pan Y, Chen W, Xu Y, Yi X, Han Y, Yang QW, Li X, Huang L, Johnston SC, Zhao X, Liu L, Zhang Q, Wang G, Wang Y, Wang Y Tags: Circulation Source Type: research
Wide Variation in Reported Rates of Stroke Across Cohorts of Patients with Atrial Fibrillation.
CONCLUSIONS: -There is substantial variation across cohorts in overall stroke rates and rates corresponding to CHA2DS2-VASc point scores. These variations can affect the point score threshold for recommending OAC in AF. The majority of cohorts did not observe stroke rates that would indicate a clear expected net clinical benefit for anticoagulating AF patients with CHA2DS2-VASc scores of 1 or 2.
PMID: 27799272 [PubMed - as supplied by publisher]
Source: Circulation - October 30, 2016 Category: Cardiology Authors: Quinn GR, Severdija ON, Chang Y, Singer DE Tags: Circulation Source Type: research
Clinical Outcomes in 3343 Children and Adults with Rheumatic Heart Disease from 14 Low and Middle Income Countries: 2-Year Follow-up of the Global Rheumatic Heart Disease Registry (the REMEDY study).
CONCLUSIONS: -Patients with clinical RHD have high mortality and morbidity despite being young; those from low and lower-middle income countries had a poorer prognosis associated with advanced disease and low education. Programs focused on early detection and treatment of clinical RHD are required to improve outcomes.
PMID: 27702773 [PubMed - as supplied by publisher]
Source: Circulation - October 3, 2016 Category: Cardiology Authors: Zühlke L, Karthikeyan G, Engel ME, Rangarajan S, Mackie P, Cupido B, Mauff K, Islam S, Daniels R, Francis V, Ogendo S, Gitura B, Mondo C, Okello E, Lwabi P, Al-Kebsi MM, Hugo-Hamman C, Sheta SS, Haileamlak A, Daniel W, Goshu DY, Abdissa SG, Desta AG, Sha Tags: Circulation Source Type: research
Retinal Vessel Calibers in Predicting Long-term Cardiovascular Outcomes: The Atherosclerosis Risk in Communities Study.
CONCLUSIONS: -Narrower retinal arterioles and wider retinal venules conferred long-term risk of mortality and ischemic stroke in both genders and CHD in women. These measures serve as an inexpensive, reproducible biomarker that added incremental value to current practice guidelines in ASCVE risk prediction in low-risk women.
PMID: 27682886 [PubMed - as supplied by publisher]
Source: Circulation - September 27, 2016 Category: Cardiology Authors: Seidelmann SB, Claggett B, Bravo PE, Gupta A, Farhad H, Klein BE, Klein R, Di Carli MF, Solomon SD Tags: Circulation Source Type: research
Prasugrel versus Ticagrelor in Patients with Acute Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention: Multicenter Randomized PRAGUE-18 Study.
CONCLUSION: This head-to-head comparison of prasugrel and ticagrelor does not support the hypothesis that one is more effective or safer than the other in preventing ischemic and bleeding events in the acute phase of myocardial infarction treated with primary PCI strategy. The observed rates of major outcomes were similar, although with broad confidence intervals around the estimates. These interesting observations need to be confirmed in a larger trial.
CLINICAL TRIAL REGISTRATION: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02808767.
PMID: 27576777 [PubMed - as supplied by publisher]
Source: Circulation - August 29, 2016 Category: Cardiology Authors: Motovska Z, Hlinomaz O, Miklik R, Hromadka M, Varvarovsky I, Dusek J, Knot J, Jarkovsky J, Kala P, Rokyta R, Tousek F, Kramarikova P, Majtan B, Simek S, Branny M, Mrozek J, Cervinka P, Ostransky J, Widimsky P Tags: Circulation Source Type: research
Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54).
CONCLUSIONS: High-risk patients with prior myocardial infarction are at risk for stroke, approximately one-third of which are fatal or lead to moderate-to-severe disability. The addition of ticagrelor 60 mg twice daily significantly reduced this risk without an excess of hemorrhagic stroke but with more major bleeding. In high-risk patients with coronary disease, more intensive antiplatelet therapy should be considered not only to reduce the risk of coronary events, but also of stroke.
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01225562.
PMID: 27576775 [PubMed - as supplied by publisher]
Source: Circulation - August 29, 2016 Category: Cardiology Authors: Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu DY, Dalby AJ, Jensen EC, Held P, Morrow DA, Braunwald E, Sabatine MS Tags: Circulation Source Type: research
Atherothrombotic Risk Stratification and the Efficacy and Safety of Vorapaxar in Patients with Stable Ischemic Heart Disease and Prior Myocardial Infarction.
CONCLUSIONS: -Stratification of baseline atherothrombotic risk can assist with therapeutic decision-making regarding vorapaxar use for secondary prevention after MI. Clinical Trial Registration-http://www.clinicaltrials.gov; NCT00526474.
PMID: 27440003 [PubMed - as supplied by publisher]
Source: Circulation - July 19, 2016 Category: Cardiology Authors: Bohula EA, Bonaca MP, Braunwald E, Aylward PE, Corbalan R, De Ferrari GM, He P, Lewis BS, Merlini PA, Murphy SA, Sabatine MS, Scirica BM, Morrow DA Tags: Circulation Source Type: research
