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Changes in blood pressure and cardiovascular disease in middle-aged to older Chinese: the Guangzhou Biobank Cohort Study
Conclusion: Most people between 50 and 70 years of age and not taking antihypertensive medication maintained a slow increase SBP trajectory over a follow-up period of approximately 7 years. However, those whose SBPs increased from low and moderate levels were associated with higher CVD risks.
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Impact of estimated pulse wave velocity and socioeconomic status on the risk of stroke in men: a prospective cohort study
Objective: High pulse wave velocity (PWV) and low socioeconomic status (SES) are each associated with increased risk of stroke, but clarification of the interplay between PWV, SES and the risk of stroke appears to be warranted to identify vulnerable populations at high risk of stroke. We conducted a prospective study that examined the independent and joint associations of PWV and SES with the risk of stroke in the general population. Methods: The current study included 2666 men aged 42–61 years, who were enrolled in the Kuopio Ischaemic Heart Disease Study cohort. Estimated PWV (ePWV), a proxy of carotid-fem...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Blood pressure undulation of peripheral thrombolysis period in acute ischemic stroke is associated with prognosis
Conclusion: Higher BPV and SBP from prior IVT to 72 h after IVT was associated with higher risk of stroke outcomes within 3 months.
Source: Journal of Hypertension - March 10, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

White-coat hypertension/effect is associated with higher arterial stiffness and stroke events
This study aimed to investigate the relationship between WCH/E, markers of cardiovascular risk and cerebrovascular events. Methods: This is a sub-group analysis of The Arterial Stiffness In lacunar Stroke and Transient ischemic attack (ASIST) study, which recruited 96 patients aged at least 40 years old with a diagnosis of transient ischemic attack or lacunar stroke in the preceding 14 days. Thirty-two patients with target blood pressure (clinic blood pressure
Source: Journal of Hypertension - March 10, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Neurologically asymptomatic patients frequently present cerebral injuries during malignant hypertension: a MRI study
Conclusion: PRES, recent hematoma, ischemic stroke and severe cerebral microangiopathy are common findings in MHT patients without neurological signs on admission. The impact of these findings on patient management, and their cerebrovascular and cognitive prognostic value, should be established. Brain MRI might need to become systematic in patients suffering from MHT episodes.
Source: Journal of Hypertension - November 19, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Global burden of cardiovascular diseases attributable to hypertension in young adults from 1990 to 2019
Conclusions: Hypertension attributable CVDs burden in young adults has greatly increased from 1990 to 2019, with considerably spatiotemporal and sexual heterogeneity. The largest burden was borne by middle-income countries, especially by men. Establishment of geographically and sexually tailored strategies were needed to prevent hypertension-related CVDs in young adults.
Source: Journal of Hypertension - November 19, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology and genetics Source Type: research

The association between the Moyamoya disease susceptible gene RNF213 variant and incident cardiovascular disease in a general population: the Nagahama study
Objective: An association between the Moyamoya disease susceptible gene ring finger protein 213 (RNF213) variant and ischemic stroke and coronary artery disease has been suggested in case-control studies. We aimed to investigate the possible association between the RNF213 variant and the incidence of cardiovascular disease in a general population. Methods: The study participants consisted of 9153 Japanese community residents without history of cardiovascular disease. The clinical parameters employed in this analysis were observed at baseline between 2008 and 2010. The RNF213 p.R4859K variant was determined by Ta...
Source: Journal of Hypertension - November 19, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology and genetics Source Type: research

Risk factors predisposing to acute stroke in India: a prospective study
Conclusion: The foremost risk factors for stroke in India, hypertension and diabetes, need to be controlled and treated like other global high-risk populations for stroke prevention. The NIHSS scores highlight the relationship between risk factors and stroke severity.
Source: Journal of Hypertension - October 15, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Risk factors Source Type: research

Novel insights into stroke risk beyond resting and maximal bicycle exercise systolic blood pressure
Conclusion: Stroke risk increased with increasing difference between resting and maximal exercise SBP, independent of BP at rest, suggesting that an exaggerated BP response to physical exercise may be an independent predictor of stroke.
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Blood pressure, blood pressure variability and the risk of poststroke dementia
Conclusion: Among patients with a recent noncardioembolic ischemic stroke, there appears to be a U-shaped association between achieved SBP and dementia. High blood pressure variability is associated with an increased risk of poststroke dementia.
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure variability Source Type: research

Isolated systolic and diastolic hypertension by the 2017 American College of Cardiology/American Heart Association guidelines and risk of cardiovascular disease: a large prospective cohort study
Objective: The 2017 American College of Cardiology/American Heart Association blood pressure (BP) guidelines lowered the hypertension threshold from a SBP/DBP level of at least 140/90 mmHg to at least 130/80 mmHg. The cardiovascular impact of isolated systolic hypertension (ISH) and isolated diastolic hypertension (IDH) under the new definition remains unclear. Methods: We used data from the UK Biobank study, which is a prospective population-based cohort study. Participants were categorized into five groups: normal BP, normal high BP, ISH, IDH and systolic and diastolic hypertension. The primary endpoint fo...
Source: Journal of Hypertension - July 9, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Optimal blood pressure levels in different phases of peripheral thrombolysis period in acute ischemic stroke
Conclusions: Maintaining SBP levels (≤148 mmHg) from admission to the first 24 h after thrombolysis, then keeping SBP levels (127–138 mmHg) would be beneficial.
Source: Journal of Hypertension - June 11, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Country of birth and mortality risk in hypertension with and without diabetes: the Swedish primary care cardiovascular database
Conclusion: In Sweden, hypertensive immigrants (with the exception for Finnish-born) with and without diabetes have a mortality advantage, as compared to Swedish-born.
Source: Journal of Hypertension - May 14, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure epidemiology Source Type: research

Blood pressure excursions in acute ischemic stroke patients treated with intravenous thrombolysis
Conclusion: BP excursions above guideline thresholds during the first 24 h following tPA administration for AIS are common and are independently associated with adverse clinical outcomes.
Source: Journal of Hypertension - January 7, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Comparative effects of intensive-blood pressure versus standard-blood pressure-lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial
Conclusion: Intensive BP lowering is associated with increased mortality in patients with severe AIS despite lowering the risk of ICH. Further randomized trials are required to provide reliable evidence over the optimum SBP target in the most serious type of AIS. Trial registration: ClinicalTrials.gov Identifier: NCT01422616.
Source: Journal of Hypertension - January 7, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

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