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Two Sides of a Coin: Case Report of Unilateral Synangiosis and Contralateral Stroke Highlighting Consequences of Disease Progression and Efficacy of Revascularization in Sickle Cell Disease Associated Moyamoya Syndrome
We describe a challenging case where a patient with sickle cell disease undergoing standard of care management as prescribed by the Stroke Prevention Trial in Sickle Cell Anemia (STOP) and revascularization with pial synangiosis subsequently developed rapidly progressive disease in other cerebral vessels and suffered ischemic hemispheric stroke. This case demonstrates the success of management in accordance with American Heart Association (AHA) and American Stroke Association (ASA) guidelines, but also demonstrates critical areas where we lack understanding of disease progression.PMID:34879377 | DOI:10.1159/000521361
Source: Acta Haematologica - December 8, 2021 Category: Hematology Authors: Anna L Slingerland Madeline B Karsten Edward R Smith Amy E Sobota Alfred P See Source Type: research

Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720.
Abstract Sphingosine 1-phosphate (S1P) is a highly active lysophospholipid implicated in various cardiocerebrovascular events such as coagulation, myocardial infarction and stroke. However, as the functional S1P receptor antagonist, whether the S1P mimetic FTY720 can modulate coagulation and/or thrombotic formation remains largely unknown. We investigated the effects of FTY720 on adenosine diphosphate (ADP)-induced platelet aggregation, coagulation parameters and thrombus formation in rats. Pretreatment with FTY720 (2.5 mg/kg) inhibited platelet aggregation induced by ADP, elongated the thrombin time and decreased...
Source: Acta Haematologica - November 1, 2016 Category: Hematology Authors: Zhao Z, Wang R, Huo Z, Li C, Wang Z Tags: Acta Haematol Source Type: research

Acute Promyelocytic Leukemia-Associated Thrombosis.
Abstract Patients with acute promyelocytic leukemia (APL) are prone to both bleeding and thrombosis. The bleeding complications are well known. In contrast, APL-associated thrombosis is relatively underappreciated. We aimed to explore the issue of APL-associated thrombosis events. In the past 20 years, 127 cases with APL were found in our hospital database. We collected their coagulation laboratory profiles, including leukemia burdens, white blood cell and platelet counts, prothrombin time, activated partial thromboplastin time, fibrinogen levels, and disseminated intravascular coagulation scores. Data were compar...
Source: Acta Haematologica - January 23, 2013 Category: Hematology Authors: Chang H, Kuo MC, Shih LY, Wu JH, Lin TL, Dunn P, Tang TC, Hung YS, Wang PN Tags: Acta Haematol Source Type: research

Aspirin-Responsive, Migraine-Like Transient Cerebral and Ocular Ischemic Attacks and Erythromelalgia in JAK2-Positive Essential Thrombocythemia and Polycythemia Vera.
Abstract Migraine-like cerebral transient ischemic attacks (MIAs) and ocular ischemic manifestations were the main presenting features in 10 JAK2(V617F)-positive patients studied, with essential thrombocythemia (ET) in 6 and polycythemia vera (PV) in 4. Symptoms varied and included cerebral ischemic attacks, mental concentration disturbances followed by throbbing headaches, nausea, vomiting, syncope or even seizures. MIAs were frequently preceded or followed by ocular ischemic events of blurred vision, scotomas, transient flashing of the eyes, and sudden transient partial blindness preceded or followed erythromela...
Source: Acta Haematologica - August 7, 2014 Category: Hematology Authors: Michiels JJ, Berneman Z, Gadisseur A, Lam KH, De Raeve H, Schroyens W Tags: Acta Haematol Source Type: research

Long-term adherence to direct oral anticoagulants in patients with atrial fibrillation; a comparative cross-sectional study
CONCLUSION: In patients on long-term DOAC treatment, adherence to therapy was significantly increased after receiving an initial period of structured follow-up compared to standard care. Additionally, adherence to DOAC therapy was higher with once-daily treatment regimen. Significant more minor bleedings were reported in the standard care group. . These results indicate that implementation of structured follow-up of patients with AF using DOACs merits further evaluation.PMID:35306490 | DOI:10.1159/000524094
Source: Acta Haematologica - March 20, 2022 Category: Hematology Authors: Anouk J W Gulpen Dionne C W Braeken Simon Schalla Hugo Ten Cate Harry J Crijns Arina J Ten Cate-Hoek Source Type: research