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Total 1 results found since Jan 2013.

KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA
CONCLUSIONS: Our findings confirmed that simulated p-KAP1(S824) improved the survival and proliferation of endogenous NSCs. The underlying mechanism is that highly expressed p-KAP1(S824) promotes binding to PCNA, and inhibits the binding of CUL4A to PCNA. This reduced CUL4A-mediated ubiquitination degradation to increase the stability of PCNA and promote the survival and proliferation of NSCs.PMID:35799276 | DOI:10.1186/s13287-022-02962-5
Source: Cell Research - July 7, 2022 Category: Cytology Authors: Wan Wang Tianqing Yan Xinjian Guo Heng Cai Chang Liang Linyan Huang Yanling Wang Ping Ma Suhua Qi Source Type: research