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The Temporospatial Role of Microcirculatory Dysfunction in the Prediction of Ischemia or Infarction in Patients with Aneurysmal Subarachnoid Hemorrhages (P2.281)
Conclusions:This ongoing study suggests that patients with low mean minimal pulsatility index had poor functional outcomes relative to patients that had higher mean pulsatility index.Study Supported by: This work was supported in part by a grant from the McKnight Brain Research Foundation, Brain and Spinal Cord Injury Research Trust Fund, a grant from NIH National Institute of Neurological Disorders and Stroke, a Medical Student Anesthesia Research Fellowship awarded by the Foundation for Anesthesiology Education and Research, a grant from the Medical Student Research Program at the University of Florida, and the Departmen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zamora, A., Gupta, A., Leclerc, J., Vasilopoulos, T., Dore, S. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Early Palliative Care Consultation Decreases Length of Stay in Severe Stroke Patients (P1.211)
Conclusions:Early PCC in severe stroke patients decreased hospital LOS by 3 days. This may be due to prompt clarification of goals of care and hastened discharge to hospice. Advanced age, poor pre-stroke functional status, and severe post-stroke deficits and disability warrant early PCC. In addition to decreasing LOS, further study is needed to determine whether early PCC also limits futile tests, procedures, and iatrogenic complications. Ultimately, timely identification of PCC candidates may produce higher satisfaction and decreased hospital costs.Disclosure: Dr. Schloss has nothing to disclose. Dr. Tversky has nothing t...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Schloss, E. R., Tversky, S., Katz, J. M., Wright, P. Tags: Pain and Palliative Care Source Type: research

Early Improvement in NIH Stoke Scale during Inter-hospital Transfer is Common and is Associated with Lower In-hospital Mortality (P3.044)
Conclusions:Early improvement in stroke severity during interhospital transfer is common, and is not confined to patients receiving thrombolysis. These early improvement patients have very low mortality, and it is substantially lower than in those without early improvement, despite higher initial NIHSS. This has important implications for assessing the safety and efficacy of drip and ship thrombolysis or other pre-transfer interventions. Further research is warranted.Disclosure: Dr. Mahmood has nothing to disclose. Dr. Ali has nothing to disclose. Dr. Siddiqui has nothing to disclose. Dr. Cohen has nothing to disclose. Dr....
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mahmood, S., Ali, S., Siddiqui, K., Cohen, A., Schwamm, L. Tags: Practice, Policy, and Ethics III Source Type: research

Safety and Efficacy of IV-tPA Use in Patients 80 Years and Older- A Retrospective Review (P2.305)
Conclusion—We observed no increase in sICH post IV-tPA in patients 80+ when compared to those younger. Higher mortality in those 80+ likely due to baseline disabilities. Within the 80+ group, predictors of mortality and poor outcomes included disabilities prior to hospitalization, prior stroke/TIA, higher NIHSS at admission, sICH post treatment and higher diastolic blood pressure.Disclosure: Dr. Lau has nothing to disclose. Dr. Romero has nothing to disclose. Dr. Kwan has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Babikian has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Lau, H., Romero, J., Kwan, S., Kase, C., Babikian, V. Tags: Acute Therapy: IV t-PA Source Type: research

TIA Biomarkers Determined Through Proteomics (S30.002)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Diagnostics, Biomarkers, and Genetics Platform Blitz Source Type: research

Significance of Periclot MMP-9 in Ischemic Stroke Patients Undergoing Intra-arterial Interventions (P4.303)
CONCLUSIONS: Decreased periclot MMP-9 may be predictive of HT after ischemic stroke, contrasting with previous work demonstrating elevated peripheral MMP-9 as predictive of HT. Increased periclot MCP-4 and angiogenin expression, as well as decreased numbers of circulating monocytes, may serve as additional predictive markers of HT. Future work should measure the activity of periclot MMP-9. Study Supported by: Shimojani, LLC and NIH (DJ).Disclosure: Dr. Song has nothing to disclose. Dr. Prager has nothing to disclose. Dr. Brennan has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Hussain has nothing to disclos...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Song, A., Prager, B., Brennan, C., Uchino, K., Hussain, M., Rasmussen, P., Janigro, D. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Interventional Treatment for Ischemic Stroke Source Type: research

TIA Biomarkers Determined Through Proteomics (I11-1A)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: The Promise of Novel Biomarker Approaches in Advancing Treatment Data Blitz Presentations Source Type: research

A Novel Method for Measuring Oxidative Stress in Patients with Stroke Symptoms (S52.005)
CONCLUSIONS: These results demonstrate the ability of ORP to identify oxidative stress and amount of antioxidant reserves in a stroke population. We propose ORP monitoring as a potentially useful tool in evaluation of acute stroke patients.Disclosure: Dr. Wagner has received personal compensation for activities with Genentech, Inc. Dr. Salottolo has nothing to disclose. Dr. Fanale has received personal compensation for activities with Genentech, Inc. as a speaker. Dr. Whaley has nothing to disclose. Dr. McCarthy has nothing to disclose. Luoxis Diagnostics, Inc,
Source: Neurology - April 8, 2015 Category: Neurology Authors: Wagner, J., Salottolo, K., Fanale, C., Whaley, M., McCarthy, K., BarOr, D. Tags: General Neurology: Neural Networks and Neuromodulation Source Type: research

Quality Improvement Project: Improving the Time To Treatment in Inpatient Acute Ischemic Stroke (P7.130)
Conclusion/Proposal: In the inpatient setting there was a significant delay in the time to CT-scan and to t-PA; the main source of delay was time to CT-scan. There are many possible reasons for the delay: location of the CT-scanner, unfamiliarity with strokes by non-neurology staff, ready availability of t-PA. We proposed to target house staff education and t-PA availability. We developed a "stroke-code" checklist to be distributed to house staff from different services after a small explanatory lecture. We also developed an order form to create a zero wait time for t-PA, allowing the RN/PCA to be the first one served in t...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Liang, J., Garcia Santibanez, R., Walker, A., Boniece, I. Tags: Cerebrovascular Disease and Interventional Neurology: Barriers and Opportunities in Acute Stroke Treatment Source Type: research

Identifying Novel Biomarkers of Cerebral Ischemia through the Use of Mass Spectroscopy (S15.004)
CONCLUSIONS: Mass spectroscopy-based proteomics is a potential new tool to help identify biomarkers for cerebral ischemia. Ultimately, a panel of proteins may serve as a marker for cerebral ischemia or TIA. We have identified three candidate proteins as possible indicators for cerebral ischemia. Larger studies are needed to confirm our results. Study Supported by: Stanford Cardiovascular Institute; American Brain Foundation and American Academy of Neurology Clinical Research Training FellowshipDisclosure: Dr. George has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Kjaerga...
Source: Neurology - April 9, 2014 Category: Neurology Authors: George, P., Adams, C., Mlynash, M., Kjaergaard, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Clinical and Imaging Biomarkers and Genetics Source Type: research

Blacks Are Less Likely To Be Admitted with Transient Ischemic Attack Than Whites in the Bronx (P03.197)
CONCLUSIONS: The TIA-IS ratio differs by age, gender and race, raising the question of whether some groups are less likely to be admitted with TIA than others. We suspect that the differences are related to physician and patient behavior. In particular, blacks, particularly black men, may be less likely to obtain emergency care for TIA symptoms than whites or Hispanics. If confirmed, this finding would support targeting resources for public education on TIA to black Americans.Disclosure: Dr. Bhupali has nothing to disclose. Dr. Labovitz has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bhupali, D., Labovitz, D. Tags: P03 Cerebrovascular Disease III Source Type: research