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Mechanical Thrombectomy in Ischemic Stroke Patients with Severe Pre-Stroke Disability
Frequency and outcomes of mechanical thrombectomy (MT) in clinical practice for patients with severe pre-stroke disability are largely unknown. In this case series, we aim to describe the disability make-up and outcomes of 33 patients with severe pre-stroke disability undergoing MT. Patients with a permanent, severe, pre-stroke disability (modified Rankin Score, mRS, 4-5) were identified from a prospectively-maintained database of consecutive, MT-treated, anterior circulation acute ischemic stroke patients at two comprehensive stroke centers in the United States.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Sanjana Salwi, Shawna Cutting, Alan D. Salgado, Kiersten Espaillat, Matthew R. Fusco, Michael T. Froehler, Rohan V. Chitale, Howard Kirshner, Matthew Schrag, Adam Jasne, Tina Burton, Brian Mac Grory, Ali Saad, Mahesh V. Jayaraman, Tracy E. Madsen, Katarin Source Type: research

Influence of a Comorbid Diagnosis of Seizure on 30-Day Readmission Rates Following Hospitalization for an Index Stroke
Objective: To examine the association of a comorbid seizure diagnosis with early hospital readmission rates following an index hospitalization for stroke in the United States. Methods: Retrospective analysis of the 2014 National Readmission Database. The study population included adult patients (age>18 years old) with stroke, identified using the International Classification of Disease Ninth Revision, Clinical Modification (ICD-9-CM) codes 433.X1, 434.X1, and 436 for ischemic stroke as well as 430, 431, 432.0, 432.1, and 432.9 for hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2019 Category: Neurology Authors: Alain Lekoubou, Kinfe G Bishu, Bruce Ovbiagele Source Type: research

Effect of Insurance Status on Outcomes of Acute Ischemic Stroke Patients Receiving Intra-Arterial Treatment: Results from the Paul Coverdell National Acute Stroke Program
Stroke continues to be a leading cause of death and disability in the United States. Rates of intra-arterial reperfusion treatments (IAT) for acute ischemic stroke (AIS) are increasing, and these treatments are associated with more favorable outcomes. We sought to examine the effect of insurance status on outcomes for AIS patients receiving IAT within a multistate stroke registry.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2021 Category: Neurology Authors: Ganesh Asaithambi, Xin Tong, Kamakshi Lakshminarayan, Sallyann M Coleman King, Mary G George Source Type: research

Mechanisms of in-hospital acute ischemic stroke and their relevance to prognosis: A retrospective analysis
In-hospital stroke (IHS) refers to stroke that occurs during hospitalization in patients admitted for other diagnoses,1 of which ischemic stroke is the most common type, accounting for approximately 60% to 89%.2,3 IHS is common with approximately 35,000 to 75,000 patients having a stroke while hospitalized in the United States each year.4 The incidence of IHS tends to increase per year,5 resulting in a serious social burden. In-hospital ischemic strokes are widely distributed across various in-hospital departments.
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2023 Category: Neurology Authors: Juanjuan Wu, Guangsong Han, Yuhui Sha, Mingyu Tang, Ziang Pan, Ziyue Liu, Yicheng Zhu, Lixin Zhou, Jun Ni Source Type: research

Hospital Discharge and Readmissions Before and During the COVID-19 Pandemic for California Acute Stroke Inpatients
Stroke is a leading cause of death and disability in the United States, with approximately 795,000 new strokes occurring annually, including acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).1 The Coronavirus Disease 2019 (COVID-19) pandemic has impacted all levels of care for stroke patients, such as delays in initial presentation, reduction in acute therapies, limitations of in-patient resources, delays or lack of initiation of secondary stroke prevention therapy, and limitations in rehabilitation services after hospital discharge.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2023 Category: Neurology Authors: George P. Albert, Daryl C. McHugh, Debra E. Roberts, Adam G. Kelly, Remi Okwechime, Robert G. Holloway, Benjamin P. George Source Type: research

Association of serum uric acid with risk of stroke in US adults: A cross-sectional study from NHANES 1999 –2020
Stroke is the second-most global death cause, only after ischemic heart disease, and third-most contributor to disability1, making it a major therapeutic challenge. More than 100 million individuals worldwide experience stroke every year, of which 795,000 cases are in the United States.2 Therefore, improved preventive strategies are needed; particularly, strategies targeting the modifiable risk factors of stroke, such as hypertension, hyperglycemia, and dyslipidemia, may help prevent more than approximately 90% of stroke cases.
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2023 Category: Neurology Authors: Bei Gao, Yun Bao, Min Meng, Lijun Yu, Yali Lu, Rina Sa, Xiaoyan Liang, Jie Shi Source Type: research

Body mass index and waist circumference as predictors of recurrent vascular events after a recent ischemic stroke
Obesity is an independent contributor to ischemic stroke incidence. A meta-analysis of 13 studies revealed that a 5 kg/m2 increase in body mass index (BMI) was associated with a 22% increased risk of ischemic stroke in European/North American/Australian cohorts and a 35% increased risk of ischemic stroke among the Asian populations.1 In a meta-analysis of 7 prospective studies, persons in the highest waist circumference (WC) category had a relative risk of 1.41 (95% CI, 1.21 ⁠–1.56) for ischemic stroke compared with persons in the lowest category.
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2023 Category: Neurology Authors: Kyusik Kang, Jong-Moo Park, Wi-Sun Ryu, Sang-Wuk Jeong, Dong-Eog Kim, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Juneyoung Lee, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae Source Type: research

Trends in Interhospital Transfers and Mechanical Thrombectomy for United States Acute Ischemic Stroke Inpatients
Objective: Stroke care in the US is increasingly regionalized. Many patients undergo interhospital transfer to access specialized, time-sensitive interventions such as mechanical thrombectomy. Methods: Using a stratified survey design of the US Nationwide Inpatient Sample (2009-2014) we examined trends in interhospital transfers for ischemic stroke resulting in mechanical thrombectomy. International Classification of Disease —Ninth Revision (ICD-9) codes were used to identify stroke admissions and inpatient procedures within endovascular-capable hospitals.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Benjamin P. George, Thomas A. Pieters, Christopher G. Zammit, Adam G. Kelly, Kevin N. Sheth, Tarun Bhalla Source Type: research

Association Between Dispatch Complaint and Critical Prehospital Time Intervals in Suspected Stroke 911 Activations in the National Emergency Medical Services Information System, 2012 –2016
Stroke, one of the leading causes of death and disability in the United States (US), is a time sensitive emergency.1 Receiving timely treatment is associated with increased survival and better outcomes.2 –5 For every minute that treatment is delayed, a patient with stroke may lose an estimated 1.9 million neurons, leading to irreversible brain tissue damage long term disability, or death.6 Several studies have demonstrated that treatment with intravenous recombinant tissue-type plasminogen activat or (IV alteplase) can positively affect clinical outcomes when administered within a critical timeframe after ischemic stroke symptom onset.
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2021 Category: Neurology Authors: Amena Y. Abbas, Erika C. Odom, Isaac Nwaise Source Type: research

Global Metabolomic Profiling Reveals Disrupted Lipid and Amino Acid Metabolism Between the Acute and Chronic Stages of Ischemic Stroke
Stroke is a major cause of serious disability in the United States. Previous studies found multiple associations of serum metabolites with acute ischemic stroke (AIS) compared to controls, but few of them evaluated metabolome in a longitudinal fashion. Therefore, we compared the metabolome of the acute and chronic stages of ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 29, 2022 Category: Neurology Authors: Evgeny V. Sidorov, Chao Xu, Jonathan Garcia-Ramiu, Apple Blair, Jorge Ortiz-Garcia, David Gordon, Juliane Chainakul, Dharambir K. Sanghera Source Type: research

Vascular Risk Factor Prevalence and Trends in Native Americans with Ischemic Stroke
Native Americans have a higher incidence and prevalence of stroke and the highest stroke-related mortality among race-ethnic groups in the United States. We aimed to analyze trends in the ischemic stroke (IS) vascular risk factor prevalence in Native Americans along with a comparison to the other race-ethnic groups.
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2022 Category: Neurology Authors: Dinesh V. Jillella, Sara Crawford, Rocio Lopez, Atif Zafar, Anne S. Tang, Ken Uchino Source Type: research

Functional Recovery in Patients with Acute Stroke and Pre-Existing Disability: A Natural History Study
One million strokes occur in the United States every year, with as many as 1 in 3 occurring among patients with a pre-existing disability.1,2 Though they are a significant portion of the stroke population, such patients are often excluded from interventional trials.3-5 As a result, acute ischemic stroke patients with pre-morbid disability are often omitted from clinical practice treatment guidelines, such as for mechanical thrombectomy (MT). In the latest American Heart Association (AHA) guidelines, MT is only indicated for patients with no pre-stroke disability, as defined by a modified Rankin scale (mRS) score of 0-1.
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2022 Category: Neurology Authors: Nicholas Vigilante, Scott Kamen, Ryan Shannon, Lauren Thau, Miriam Butler, Solomon Oak, Linda Zhang, Taryn Hester, Jesse M. Thon, James E. Siegler Source Type: research

Ischemic Stroke and Impact of Thyroid Profile at Presentation: A Systematic Review and Meta-analysis of Observational Studies
Stroke is the fifth leading cause of mortality in the United States and a leading cause of disability. A complex relationship between thyroid hormone levels and severity of, and outcome after, stroke has been described.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2017 Category: Neurology Authors: Rashmi Dhital, Dilli Ram Poudel, Niranjan Tachamo, Bishal Gyawali, Sijan Basnet, Pragya Shrestha, Paras Karmacharya Source Type: research

Racial Difference in Cerebral Microbleed Burden among Ischemic Stroke Patients
This study compared the number, associated factors, and topography of CMBs between African American and Caucasian ischemic stroke patients in the Mid-South United States.
Source: Journal of Stroke and Cerebrovascular Diseases - August 22, 2017 Category: Neurology Authors: Shima Shahjouei, Georgios Tsivgoulis, Mantinderpreet Singh, Michael McCormack, Nariman Noorbakhsh-Sabet, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Ramin Zand Source Type: research

Social Network Simulation Identifies Persistent Racial Disparities Of Delay To Hospital In Acute Ischemic Stroke Patients
Delayed arrival to the hospital remains the major reason for not deploying stroke therapies. In the United States, minority patients have longer delays that have not been adequately understood nor acted upon. Social context plays a key role, because most strokes occur in front of witnesses who influence decision-making. We created a social network simulation to understand the interpersonal factors that influence decision-making following acute stroke, particularly in minority patients.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2020 Category: Neurology Authors: Rachel Greben Tags: Poster 01 Source Type: research

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