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Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/ β-catenin signalling pathway
CONCLUSION: This study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/β-catenin signalling pathway under ischemic conditions.PMID:34857032 | DOI:10.1186/s40779-021-00356-x
Source: Cell Research - December 3, 2021 Category: Cytology Authors: Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Source Type: research

MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN
CONCLUSIONS: Taken together, our findings indicate miR-499a as an important factor to prevent inflammatory response and suggest miR-499a as a new molecule for the treatment of IS. The present study also demonstrated the relationship between miR-499a and PTEN, with PTEN as a downstream signaling mediator of miR-499a in the inflammatory response of astrocytes induced by IS.PMID:34632168 | PMC:PMC8488463 | DOI:10.1016/j.ncrna.2021.09.002
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Xiaoxiang Guan Yiwei Zhang Ilgiz Gareev Ozal Beylerli Xinyuan Li Guitian Lu Lin Lv Xin Hai Source Type: research

Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF- κB and SOX5/PI3K/AKT pathways
Pharmacol Res. 2022 Apr 25:106230. doi: 10.1016/j.phrs.2022.106230. Online ahead of print.ABSTRACTIschemic stroke reperfusion (IR) can cause adverse reactions including apoptosis, oxidative stress, and inflammation, but the existing therapeutic strategies have been limited. Moreover, the regulation of microglia plays an important role in brain injury after reperfusion. Hence, it is imperative to find new and effective drugs for modulating microglia to treat IR brain injury. Cyclic peptide compound cyclo-(Phe-Tyr) (Sparganin C, SC) is a compound isolated from Sparganii Rhizoma. However, the protective effects of SC on the c...
Source: Cell Research - April 28, 2022 Category: Cytology Authors: Jiale Cai Jiayin Liang Yutong Zhang Lin Shen Huiting Lin Tao Hu Sikai Zhan Meixia Xie Shengwang Liang Minghua Xian Shumei Wang Source Type: research