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Lack of Worsening of Sleep-Disordered Breathing After Recurrent Stroke in the BASIC Project
Conclusions:In this within-subject, longitudinal study, neither severity nor prevalence of SDB worsened after recurrent stroke.Citation:Brown DL, Li C, Sánchez BN, Dunietz GL, Chervin RD, Case E, Garcia NM, Lisabeth LD. Lack of worsening of sleep-disordered breathing after recurrent stroke in the BASIC project.J Clin Sleep Med. 2018;14(5):835–839.
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Role of Positive Airway Pressure Therapy for Obstructive Sleep Apnea in Patients With Stroke: A Randomized Controlled Trial
Conclusions:These findings suggest significantly better stroke outcomes and statistically nonsignificant favorable outcomes in terms of recurrence of vascular events for patients with stroke and OSA who use CPAP treatment.Clinical Trial Registration:Registry: Clinical Trials Registry - India, CTRI Registration No: CTRI/2016/07.007104, Title: Sleep Disordered Breathing in stroke patients: Effect of treatment trial, URL:http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=8682&EncHid=&userName=sleep%20disordered%20breathingCitation:Gupta A, Shukla G, Afsar M, Poornima S, Pandey RM, Goyal V, Srivastava A, Vibha D, Beha...
Source: Journal of Clinical Sleep Medicine : JCSM - April 13, 2018 Category: Sleep Medicine Source Type: research

Effect of CPAP Treatment of Sleep Apnea on Clinical Prognosis After Ischemic Stroke: An Observational Study
Conclusions:This observational study shows that CPAP treatment in stroke patients with moderate to severe SDB is associated with lower rates of stroke recurrence and death.Citation:Haba-Rubio J, Vujica J, Franc Y, Michel P, Heinzer R. Effect of CPAP treatment of sleep apnea on clinical prognosis after ischemic stroke: an observational study.J Clin Sleep Med. 2019;15(6):839–847.
Source: Journal of Clinical Sleep Medicine : JCSM - June 15, 2019 Category: Sleep Medicine Source Type: research

Nocturnal Desaturation is Associated With Atrial Fibrillation in Patients With Ischemic Stroke and Obstructive Sleep Apnea
Conclusions:Nocturnal hypoxia due to OSA is an independent predictor of AF in patients with subacute ischemic stroke. The use of overnight pulse oximeter to assess nocturnal hypoxia and predict paroxysmal AF in patients with cryptogenic stroke needs further evaluation.Commentary:A commentary on this article appears in this issue on page 667.Citation:Chen CY, Ho CH, Chen CL, Yu CC. Nocturnal desaturation is associated with atrial fibrillation in patients with ischemic stroke and obstructive sleep apnea.J Clin Sleep Med. 2017;13(5):729–735.
Source: Journal of Clinical Sleep Medicine : JCSM - May 13, 2017 Category: Sleep Medicine Source Type: research

Nocturnal Desaturation is Associated With Neurological Deterioration Following Ischemic Stroke: A Retrospective Observational Study
Conclusions:NOD in the SU was associated with END, especially during nighttime, after ischemic stroke. This suggests that treatment of sleep-disordered breathing could be a modifiable factor to possibly reduce the risk of neurological worsening among acute stroke patients.Citation:Kim TJ, Ko SB, Jeong HG, Kim CK, Kim Y, Nam K, Mo H, An SJ, Choi HA, Yoon BW. Nocturnal desaturation is associated with neurological deterioration following ischemic stroke: a retrospective observational study.J Clin Sleep Med. 2017;13(11):1273–1279.
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2017 Category: Sleep Medicine Source Type: research

The Effect of Sleep Disordered Breathing on the Outcome of Stroke and Transient Ischemic Attack: A Systematic Review
Conclusions:Existing studies provide sufficient data to establish obstructive SDB as a negative predictor of all-cause mortality and recurrent vascular events following stroke or TIA. The ability of CPAP treatment to lower the risk of serious adverse outcomes after stroke remains controversial because of substantial risk of bias identified in most of the eligible studies addressing this relation. Additional studies are needed.Citation:Birkbak J; Clark AJ; Rod NH. The effect of sleep disordered breathing on the outcome of stroke and transient ischemic attack: a systematic review. J Clin Sleep Med 2014;10(1):103-108.
Source: Journal of Clinical Sleep Medicine : JCSM - January 14, 2014 Category: Sleep Medicine Source Type: research

Association of Sleep Disordered Breathing with Wake-Up Acute Ischemic Stroke: A Full Polysomnographic Study
Conclusions:Although the design of our study does not prove the causal relationship between SDB and WUS, higher severity of SDB parameters in WUS supports this hypothesis.Commentary:A commentary on this article appears in this issue on page 467.Citation:Šiarnik P, Kollár B, Čarnická Z, Šurda P, Klobučníková K, Sýkora M, Turčáni P. Association of sleep disordered breathing with wake-up acute ischemic stroke: a full polysomnographic study. J Clin Sleep Med 2016;12(4):549–554.
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2016 Category: Sleep Medicine Source Type: research

Effect of Continuous Positive Airway Pressure on Stroke Rehabilitation: A Pilot Randomized Sham-Controlled Trial
Conclusions:A sham-controlled CPAP trial among stroke rehabilitation patients was feasible in terms of recruitment, treatment without diagnostic testing and adequate blinding—though was limited by study retention and CPAP adherence. Despite these limitations, a trend towards a benefit of CPAP on recovery was evident. Tolerance and adherence must be improved before the full benefits of CPAP on recovery can be assessed in larger trials.Citation:Khot SP, Davis AP, Crane DA, Tanzi PM, Li Lue D, Claflin ES, Becker KJ, Longstreth WT, Watson NF, Billings ME. Effect of continuous positive airway pressure on stroke rehabilita...
Source: Journal of Clinical Sleep Medicine : JCSM - July 15, 2016 Category: Sleep Medicine Source Type: research

The Evolution of Sleep Apnea Six Months After Acute Ischemic Stroke and Thrombolysis
Conclusions:Sleep apnea prevalence remained high in patients who had an ischemic stroke at 6 months post-stroke. The risk for developing sleep apnea after stroke was significantly lower among patients undergoing thrombolysis.Clinical Trial Registration:Registry: ClinicalTrials.gov; Title: Ischaemic Stroke and Sleep Apnea in Northern Part of Finland; Identifier: NCT01861275; URL:https://clinicaltrials.gov/ct2/show/NCT01861275Citation:Huhtakangas JK, Saaresranta T, Bloigu R, Huhtakangas J. The evolution of sleep apnea six months after acute ischemic stroke and thrombolysis.J Clin Sleep Med. 2018;14(12):2005–2011.
Source: Journal of Clinical Sleep Medicine : JCSM - December 15, 2018 Category: Sleep Medicine Source Type: research

Sleep Apnea and 20-Year Follow-Up for All-Cause Mortality, Stroke, and Cancer Incidence and Mortality in the Busselton Health Study Cohort
Conclusions:Moderate-to-severe sleep apnea is independently associated with a large increased risk of all-cause mortality, incident stroke, and cancer incidence and mortality in this community-based sample.Commentary:A commentary on this article appears in this issue on page 363.Citation:Marshall NS; Wong KK; Cullen SR; Knuiman MW; Grunstein RR. Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton health study cohort. J Clin Sleep Med 2014;10(4):355-362.
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2014 Category: Sleep Medicine Source Type: research

Nocturnal Hypoxemia Is Associated with White Matter Hyperintensities in Patients with a Minor Stroke or Transient Ischemic Attack
Conclusions:We conclude that nocturnal hypoxemia, predominantly related to OSA, is independently associated with WMH in patients who present with minor ischemic stroke and TIA and may contribute to its pathogenesis.Citation:Patel SK, Hanly PJ, Smith EE, Chan W, Coutts SB. Nocturnal hypoxemia is associated with white matter hyperintensities in patients with a minor stroke or transient ischemic attack. J Clin Sleep Med 2015;11(12):1417–1424.
Source: Journal of Clinical Sleep Medicine : JCSM - December 15, 2015 Category: Sleep Medicine Source Type: research

Expiratory Positive Airway Pressure for Sleep Apnea after Stroke: A Randomized, Crossover Trial
Conclusions:This study suggests that EPAP is not an effective alternative to CPAP in acute stroke patients with OSA. Further work is needed to identify other more effective alternatives.Clinical Trial Registration:ClinicalTrials.gov, ID: NCT01703663Citation:Wheeler NC, Wing JJ, O'Brien LM, Hughes R, Jacobs T, Claflin E, Chervin RD, Brown DL. Expiratory positive airway pressure for sleep apnea after stroke: a randomized, crossover trial.J Clin Sleep Med 2016;12(9):1233–1238.
Source: Journal of Clinical Sleep Medicine : JCSM - September 15, 2016 Category: Sleep Medicine Source Type: research

Excessive Daytime Sleepiness in Acute Ischemic Stroke: Association With Restless Legs Syndrome, Diabetes Mellitus, Obesity, and Sleep-Disordered Breathing
Conclusions:Our results suggest a significant association of ESS with RLS, diabetes mellitus, and obesity in patients with acute ischemic stroke.Citation:Šiarnik P, Klobučníková K,Šurda P, Putala M,Šutovský S, Kollár B, Turčáni P. Excessive daytime sleepiness in acute ischemic stroke: association with restless legs syndrome, diabetes mellitus, obesity, and sleep-disordered breathing.J Clin Sleep Med. 2018;14(1):95–100.
Source: Journal of Clinical Sleep Medicine : JCSM - January 13, 2018 Category: Sleep Medicine Source Type: research

Home Sleep Apnea Testing is a Feasible and Accurate Method to Diagnose Obstructive Sleep Apnea in Stroke Patients During In-Hospital Rehabilitation
Conclusions:These findings confirm a good feasibility and sufficient accuracy of HSAT attached in a stroke rehabilitation unit. Therefore, the authors suggest that American Academy of Sleep Medicine recommendations for HSAT should include stroke patients.Citation:Saletu MT, Kotzian ST, Schwarzinger A, Haider S, Spatt J, Saletu B. Home sleep apnea testing is a feasible and accurate method to diagnose obstructive sleep apnea in stroke patients during in-hospital rehabilitation.J Clin Sleep Med. 2018;14(9):1495–1501.
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Oximetry as an Accurate Tool for Identifying Moderate to Severe Sleep Apnea in Patients With Acute Stroke
Conclusions:Nocturnal pulse oximetry has a high diagnostic accuracy in predicting moderate to severe SDB in patients with acute stroke. Oximetry can be a simple modality to rapidly recognize patients with more severe SDB and facilitate the referral to the confirmation sleep study.Citation:Lin SH, Branson C, Park L, Leung J, Doshi N, Auerbach SH. Oximetry as an accurate tool for identifying moderate to severe sleep apnea in patients with acute stroke.J Clin Sleep Med. 2018;14(12):2065–2073.
Source: Journal of Clinical Sleep Medicine : JCSM - December 15, 2018 Category: Sleep Medicine Source Type: research

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