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Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease ‐related changes
Transfer RNA fragments (tRFs) are important regulatory small RNAs with diverse functions. We studied age, sex, and Parkinson's disease (PD) effects on the distributions of tRFs in the cerebrospinal fluid (CSF) and blood, in NIH and PPMI datasets. We discovered that CSF tRFs were more variable in length and cleavage subtypes, negatively correlated with age and showed more pronounced differences between males and females than blood tRFs. Both CSF and blood tRFs differentiated PD patients from controls, based on distinct subsets of tRFs, both highly enriched with mitochondrial Cholino-tRFs. Our findings point at tRFs as a pro...
Source: Journal of Neurochemistry - November 23, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson's disease ‐related changes
AbstractTransfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic stroke and neurodegenerative diseases, but little is known about tRF levels in the cerebrospinal fluid (CSF). To address this issue, we studied age, sex and Parkinson's disease (PD) effects on the distributions of tRFs in the CSF and blood data of healthy controls and PD patients from the NIH and the Parkinson's Progression Markers Initiative (PPMI) small RNA-seq d...
Source: Journal of Neurochemistry - November 11, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Ying Yang 1 engagement in brain pathology
AbstractHerein, we discuss data concerning the involvement of transcription factor Yin Yang 1 (YY1) in the development of brain diseases, highlighting mechanisms of its pathological actions. YY1 plays an important role in the developmental and adult pathology of the nervous system. YY1 is essential for neurulation as well as maintenance and differentiation of neuronal progenitor cells and oligodendrocytes regulating both neural and glial tissues of the brain. Lack of a YY1 gene causes many developmental abnormalities and anatomical malformations of the central nervous system (CNS). Once dysregulated, YY1 exerts multiple ne...
Source: Journal of Neurochemistry - February 24, 2022 Category: Neuroscience Authors: Sylwia Pabian ‐Jewuła, Aneta Bragiel‐Pieczonka, Marcin Rylski Tags: SYSTEMATIC REVIEW Source Type: research

Neurosteroids: a novel promise for the treatment of stroke and post ‐stroke complications
AbstractStroke is the primary reason for death and disability worldwide, with few treatment strategies to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest in the field of stroke. Neurosteroids are a kind of steroid that acts on the nervous system, and are synthesized in the mitochondria of neurons or glial cells using cholesterol or other steroidal precursors. Neurosteroids mainly include estrogen, progesterone (PROG), allopregnanolone, dehydroepiandrosterone (DHEA), and vitamin D (VD). Most of the preclinical studies have confirmed that neurosteroids can decrease the risk of strok...
Source: Journal of Neurochemistry - September 5, 2021 Category: Neuroscience Authors: Jiawei Xu, Yunxiang Zhou, Caochong Yan, Xiaoyu Wang, Jianyao Lou, Yi Luo, Shiqi Gao, Junjie Wang, Liang Wu, Xiangfu Gao, Anwen Shao Tags: REVIEW ARTICLE Source Type: research

MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy
This article is part of the 60th Anniversary special issue. MMP‐9, through cleavage of specific target proteins, plays a major role in synaptic plasticity and neuroinflammation, and by those virtues contributes to brain physiology and a host of neurological and psychiatric disorders. This article is part of the 60th Anniversary special issue.
Source: Journal of Neurochemistry - March 21, 2016 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Bench to Bedside Source Type: research

MMP ‐9 in translation: from molecule to brain physiology, pathology, and therapy
This article is part of the 60th Anniversary special issue. MMP‐9, through cleavage of specific target proteins, plays a major role in synaptic plasticity and neuroinflammation, and by those virtues contributes to brain physiology and a host of neurological and psychiatric disorders. This article is part of the 60th Anniversary special issue.
Source: Journal of Neurochemistry - March 20, 2016 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Bench to Bedside Source Type: research

MMP‐9 in Translation: From Molecule to Brain Physiology, Pathology and Therapy
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 3, 2015 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Review Source Type: research