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Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure
In this study, we investigated whether DCT supplementation in aged mice improves age-associated impairments. We obtained 5-wk-old and 1-yr-old male C57BL/6J mice and randomly assigned the aged mice to two groups, resulting in a total of three groups: 1) young mice, 2) old mice, and 3) old mice supplemented with 0.3% DCT. After 12 wk of supplementation, blood and tissue samples were collected and analyzed. DCT significantly suppressed age-associated fat accumulation, adipocyte hypertrophy, and liver steatosis. In addition, the DCT treatment dramatically suppressed age-associated increases in hepatic inflammation, immune cel...
Source: AJP: Endocrinology and Metabolism - November 29, 2017 Category: Endocrinology Authors: Ohyama, K., Suzuki, K. Tags: Research Article Source Type: research

A long-term quality-of-care score for predicting the occurrence of macrovascular diseases in patients with type 2 diabetes mellitus
Diabetes mellitus (DM) is prevalent worldwide, and the number of patients was estimated to be 382 million in 2013 and expected to rise to 592 million by 2035 [1]. In Taiwan, around 7% of the total population (about 1.6 million) had DM in 2012, 90% of whom had type 2 diabetes mellitus. DM has been among the top five leading causes of death in Taiwan for more than three decades and took up about 11.5% of the total healthcare expenditures in the recent years [2]. In addition, DM is associated with a 2-4 times higher risk of cardiovascular disease (CVD) and stroke, which are the leading causes of death and disability among peo...
Source: Diabetes Research and Clinical Practice - February 23, 2018 Category: Endocrinology Authors: Pi-I Li, Jian-Nan Wang, How-Ran Guo Source Type: research

Predicting The Onset Of Diabetes-Related Complications After A Diabetes Diagnosis With Machine Learning Algorithms
The burden of Diabetes has been ranked as the eighth cause in the ranking of causes of disability-adjusted life years (DALYs) all over the world [1,2], accounting for 2.8% of total DALYs and with an increase of more than 148% in 2019 as compared with the data obtained in 1990 [2]. Diabetes is one of the most significant factors increasing the risk of mortality, morbidity, and disability worldwide, and its economic burden demands new ways to curb diabetes healthcare expenditure [3]. Furthermore, people with diabetes are at greater risk of additionally suffering from cardiovascular diseases, such as heart attack or stroke [4...
Source: Diabetes Research and Clinical Practice - September 15, 2023 Category: Endocrinology Authors: Toni Mora, David Roche, Beatriz Rodr íguez-Sánchez Source Type: research