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Prevalence of diabetes and its effects on stroke  outcomes: A meta‐analysis and literature review
ConclusionsApproximately one ‐third of all stroke patients have diabetes. Uniform methods to screen for diabetes after stroke are required to identify individuals with diabetes to design interventions aimed at reducing poor outcomes in this high‐risk population.
Source: Journal of Diabetes Investigation - October 13, 2018 Category: Endocrinology Authors: Lik ‐Hui Lau, Jeremy Lew, Karen Borschmann, Vincent Thijs, Elif I Ekinci Tags: Original Article Source Type: research

Cardiovascular outcomes of vildagliptin in patients with type  2 diabetes mellitus after acute coronary syndrome or acute ischemic stroke
ConclusionsAmong patients with type  2 diabetes mellitus after a recent acute coronary syndrome or acute ischemic stroke, treatment with vildagliptin was not associated with increased risks of CV death, non‐fatal myocardial infarction, non‐fatal stroke and hospitalization for HF.
Source: Journal of Diabetes Investigation - June 16, 2019 Category: Endocrinology Authors: Dong ‐Yi Chen, Yan‐Rong Li, Chun‐Tai Mao, Chi‐Nan Tseng, I‐Chang Hsieh, Ming‐Jui Hung, Pao‐Hsien Chu, Chao‐Hung Wang, Ming‐Shien Wen, Wen‐Jin Cherng, Tien‐Hsing Chen Tags: Original Article Source Type: research

Association between diabetes mellitus and post ‐stroke cognitive impairment
PSD and PSCI impose heavy burdens on patients, families, and society. However, cognitive function after stroke is dynamic and dysfunction is often overlooked. Impaired fasting glucose, prediabetes, type 2 DM, hypoglycemia, and glycemic variability may lead to cognitive dysfunction after stroke via various mechanisms and pathways. There is emerging evidence regarding the association between different DM medications and cognitive functions. However, their relationship with the PSCI/PSD warrants further investigation. AbstractStroke survivors suffer from various physical, emotional, and cognitive impairments. These changes ar...
Source: Journal of Diabetes Investigation - October 1, 2022 Category: Endocrinology Authors: Kang ‐Po Lee, Jung‐Sheng Chen, Chih‐Yuan Wang Tags: Mini Review Source Type: research

Potentials of incretin‐based therapies in dementia and stroke in type 2 diabetes mellitus
In conclusion, experimental studies show promising results of incretin‐based therapies at improving the outcome of Alzheimer's disease and stroke through glucose‐independent pleiotropic effects on the brain. If these findings would indeed be confirmed in large clinical randomized controlled trials, this would have substantial impact. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - August 24, 2015 Category: Endocrinology Authors: Onno. N. Groeneveld, L. Jaap. Kappelle, Geert Jan Biessels Tags: Review Source Type: research

Low ‐density lipoprotein cholesterol and stroke – how low should we go?
AbstractDiabetes is a well ‐established risk factor for both ischemic and hemorrhagic stroke. Individuals with diabetes not only have a higher risk of stroke, they also have worse clinical outcomes after stroke, including poorer neurological recovery, higher rates of stroke recurrence and mortality. In addition to optimizin g glycemia, control of cardiovascular risk factors like hypertension and dyslipidemia is crucial in stroke prevention in subjects with diabetes.
Source: Journal of Diabetes Investigation - May 28, 2020 Category: Endocrinology Authors: David TW Lui, Kathryn CB Tan Tags: EDITORIAL Source Type: research

Cardiovascular Outcomes of Vildagliptin in Patients with Type 2 Diabetes Mellitus after Acute Coronary Syndrome or Acute Ischemic Stroke
ConclusionsAmong patients with T2DM after a recent ACS or AIS, treatment with vildagliptin was not associated with increased risks of CV death, nonfatal MI, nonfatal stroke, and hospitalization for HF.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - May 21, 2019 Category: Endocrinology Authors: Dong ‐Yi Chen, Yan‐Rong Li, Chun‐Tai Mao, Chi‐Nan Tseng, I‐Chang Hsieh, Ming‐Jui Hung, Pao‐Hsien Chu, Chao‐Hung Wang, Ming‐Shien Wen, Wen‐Jin Cherng, Tien‐Hsing Chen Tags: Original Article Source Type: research

Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study
ConclusionsRecently diagnosed type 2 diabetes patients showed increased risks of incident CVDs and premature mortality, and insulin ‐treated group demonstrated an additional increase in the risks of these outcomes in adults with recently diagnosed type 2 diabetes, suggesting the need for intensified cardio‐protective interventions for adults with insulin‐treated type 2 diabetes.
Source: Journal of Diabetes Investigation - March 19, 2021 Category: Endocrinology Authors: You ‐Bin Lee, Kyungdo Han, Bongsung Kim, Min Sun Choi, Jiyun Park, Minyoung Kim, Sang‐Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim Tags: Original Article Source Type: research

Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities
This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - April 30, 2016 Category: Endocrinology Authors: Toshitaka Umemura, Takahiko Kawamura, Nigishi Hotta Tags: Review Source Type: research

Incidence of adverse cardiovascular events in type  2 diabetes mellitus patients after initiation of glucose‐lowering agents: A population‐based community study from the Shizuoka Kokuho database
ConclusionsThe incidence of HHF was similar to that of stroke. A significant portion of our cohort met the inclusion criteria for major randomized clinical trials for SGLT2i, and estimated reduction in the HHF events was substantial.
Source: Journal of Diabetes Investigation - January 29, 2021 Category: Endocrinology Authors: Shun Kohsaka, Hiraku Kumamaru, Shiori Nishimura, Satoshi Shoji, Eiji Nakatani, Nao Ichihara, Hiroyuki Yamamoto, Yoshiki Miyachi, Hiroaki Miyata Tags: Original Article Source Type: research

Risk of early mortality and cardiovascular disease according to the presence of recently ‐diagnosed diabetes and requirement for insulin treatment: a nationwide study
ConclusionsRecently ‐diagnosed T2D patients showed increased risks of incident CVDs and premature mortality, and insulin‐treated group demonstrated an additional increase in the risks of these outcomes in adults with recently‐diagnosed T2D, suggesting the need for intensified cardio‐protective interventions for adults with insulin‐treated T2D.
Source: Journal of Diabetes Investigation - March 4, 2021 Category: Endocrinology Authors: You ‐Bin Lee, Kyungdo Han, Bongsung Kim, Min Sun Choi, Jiyun Park, Minyoung Kim, Sang‐Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim Tags: ORIGINAL ARTICLE Source Type: research

Incidence of adverse cardiovascular events in type  2 diabetes mellitus patients after initiation of glucose‐lowering agents: A population‐based community study from the Shizuoka Kokuho database
ConclusionsThe incidence of HHF was similar to that of stroke. A significant portion of our cohort met the inclusion criteria for major randomized clinical trials for SGLT2i, and estimated reduction in the HHF events was substantial.
Source: Journal of Diabetes Investigation - January 29, 2021 Category: Endocrinology Authors: Shun Kohsaka, Hiraku Kumamaru, Shiori Nishimura, Satoshi Shoji, Eiji Nakatani, Nao Ichihara, Hiroyuki Yamamoto, Yoshiki Miyachi, Hiroaki Miyata Tags: Original Article Source Type: research

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