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Source: Journal of the Neurological Sciences
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Total 39 results found since Jan 2013.
Clinico-radiological predictors of vascular cognitive impairment (VCI) in patients with stroke: A prospective observational study
Conclusion: Post-stroke cognitive impairment is frequent and is associated with poor functional outcome. Predictors like lower educational status, strategic site lesion, greater severity of age related white matter changes and baseline stroke severity independently contributed to the risk of developing VCI in stroke patients.Highlights:
Source: Journal of the Neurological Sciences - March 31, 2014 Category: Neurology Authors: Tejendra Sukdeo Chaudhari, Rajesh Verma, Ravindra Kumar Garg, Manish Kumar Singh, Hardeep Singh Malhotra, Praveen kumar Sharma Tags: Original Articles Source Type: research
Frequent inaccuracies in ABCD2 scoring in non-stroke specialists' referrals to a daily Rapid Access Stroke Prevention service
Abstract: The ‘accuracy’ of age, blood pressure, clinical features, duration and diabetes (ABCD2) scoring by non-stroke specialists referring patients to a daily Rapid Access Stroke Prevention (RASP) service is unclear, as is the accuracy of ABCD2 scoring by trainee residents.In this prospective study, referrals were classified as ‘confirmed TIAs’ if the stroke specialist confirmed a clinical diagnosis of possible, probable or definite TIA, and ‘non-TIAs’ if patients had a TIA mimic or completed stroke. ABCD2 scores from referring physicians were compared with scores by experienced stroke specialists and neurol...
Source: Journal of the Neurological Sciences - July 19, 2013 Category: Neurology Authors: David Bradley, Simon Cronin, Justin A. Kinsella, W. Oliver Tobin, Ciara Mahon, Margaret O'Brien, Róisín Lonergan, Marie Therese Cooney, Sean Kennelly, D. Rónán Collins, Desmond O'Neill, Tara Coughlan, Shane Smyth, Dominick J.H. McCabe Tags: Original Articles Source Type: research
Association of ALOX5AP1 SG13S114T/A variant with ischemic stroke, stroke subtypes and aspirin resistance
Abstract: The important role of genetic variants in the etiology and pathophysiology of stroke is being increasingly recognized. Simultaneously, the influence of genetic factors in the clinical outcome of drug therapy cannot be ignored. 5-lipoxygenase activating (ALOX5AP) gene involved in the synthesis of leukotrienes, has been recognized as an important gene contributing towards susceptibility of stroke risk. Leukotrienes are involved in the physiological mechanism of atherosclerotic events and inflammation. The present study was designed to identify the association of SG13S114T/A polymorphism in ALOX5AP1 gene with risk o...
Source: Journal of the Neurological Sciences - June 10, 2013 Category: Neurology Authors: Vandana Sharma, Sneha Dadheech, Subhash Kaul, A. Jyothy, Anjana Munshi Tags: Original Articles Source Type: research
Estimated glomerular filtration rate and incident stroke in patients with hypertension and/or diabetes
Sarfo et al. conducted a prospective study to evaluate the effect of estimated glomerular filtration rate (eGFR) on incident stroke in patients with hypertension and/or type 2 diabetes mellitus [1]. The authors had reported the risk factors of incident stroke in patients with hypertension and/or type 2 diabetes mellitus by using the same database [2]. They recognized 54 events of stroke and stroke incidence rates increased with decreasing eGFR. Adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of eGFR with 60 –89 ml/min, 30–59 ml/min, and89 ml/min for incident stroke were 1.42 (0.63–3.21), 1.88 (1....
Source: Journal of the Neurological Sciences - December 27, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research
Patients with hypertension and/or diabetes and incident stroke: A risk assessment
Sarfo et al. conducted a prospective study to evaluate the risk of hypertension and diabetes for incident stroke [1]. The authors recognized 54 events of stroke, and incidence rates (95% confidence intervals [CIs]) of stroke per 1000 person-years in patients with diabetes and hypertension, only hypertension and only diabetes were 16.64 (10.58 –25.00), 13.77 (9.33–19.64) and 9.81 (3.59–21.74), respectively. In addition, adjusted hazard ratios (95% CI) of previous cigarette smoking and physical inactivity for incident stroke were 2.59 (1.18–5.67) and 1.81 (1.06–3.10).
Source: Journal of the Neurological Sciences - December 13, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research
CHADS2 score predicts functional outcome of stroke in patients with a history of coronary artery disease
Abstract: Background: The aim of this study was to evaluate the efficacy of the CHADS2 scoring system as a prognostic tool for stroke patients with a prior history of coronary artery disease (CAD).Methods: We enrolled 148 acute ischemic stroke patients (mean age, 74.2years; males, 77.0%) with a history of CAD. Pre-admission CHADS2 scores were calculated by assigning a single point for the presence of congestive heart failure, hypertension, age ≥75years, and diabetes; and assigning 2 points for a prior history of stroke or transient ischemic attack. Comparisons were made between patients with poor and good 3-month functio...
Source: Journal of the Neurological Sciences - May 28, 2013 Category: Neurology Authors: Takao Hoshino, Kentaro Ishizuka, Satoru Shimizu, Shinichiro Uchiyama Tags: Original Articles Source Type: research
Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke
Abstract: Objective: We aimed to explore the association between abnormal glucose metabolism such as diabetes, prediabetes, and short-term prognosis in patients with acute ischemic stroke.Methods: Of 242 consecutive acute ischemic stroke patients, a 75-g oral glucose tolerance test was administered to 116 patients without previously diagnosed diabetes. One hundred forty patients were classified into diabetes, 52 patients were prediabetes (impaired glucose tolerance or impaired fasting glucose or both), and 50 patients were normal glucose tolerance (NGT). The association between each glycemic status and early neurological d...
Source: Journal of the Neurological Sciences - July 1, 2013 Category: Neurology Authors: Ryota Tanaka, Yuji Ueno, Nobukazu Miyamoto, Kazuo Yamashiro, Yasutaka Tanaka, Hideki Shimura, Nobutaka Hattori, Takao Urabe Tags: Original Articles Source Type: research
Risk factors and acute ischemic stroke subtypes
Conclusion: Specific AIS etiology and blood characteristics associated independently to the youngest and oldest AIS patients, respectively. Chronic kidney disease was a specific predictor of cerebellum–brainstem AIS. AIS mortality showed peculiar association with the oldest patients.
Source: Journal of the Neurological Sciences - January 31, 2014 Category: Neurology Authors: Aliaksei Kisialiou, Rodolfo Grella, Albino Carrizzo, Giordana Pelone, Michelangelo Bartolo, Chiara Zucchella, Francesco Rozza, Giovanni Grillea, Claudio Colonnese, Luigi Formisano, Maria Lembo, Annibale A. Puca, Carmine Vecchione Tags: Original Articles Source Type: research
Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population
In this study, we investigated, for the first time, the association between MMP-1-16071G/2G, MMP-12 -82A/G and MMP-12 1082A/G genotypes and haplotypes and the risk of ischemic stroke (IS) among patients with type 2 diabetes mellitus (T2DM). To examine whether these genetic polymorphisms are associated with susceptibility to IS, 196 patients with IS and 192 controls were examined by PCR-based RFLP. When the analyses were adjusted for multiple risk factors, no interaction between T2DM and MMP-1-1607 1G/2G polymorphism on the risk of ischemic stroke was found (p=0.074). However, MMP-12 polymorphisms genotypes were associated ...
Source: Journal of the Neurological Sciences - May 16, 2014 Category: Neurology Authors: Khouloud Chehaibi, Mohamed Yahia Hrira, Samir Nouira, Faouzi Maatouk, Khaldoun Ben Hamda, Mohamed Naceur Slimane Tags: Original Articles Source Type: research
Comparative effects of low-dose versus standard-dose alteplase in ischemic patients with prior stroke and/or diabetes mellitus: The ENCHANTED trial
History of prior stroke (PS) and diabetes mellitus (DM) are considered relative contraindications to the use of intravenous alteplase in patients with acute ischemic stroke (AIS). We aimed to assess whether a history of PS and DM modified the comparative effects of low- versus standard-dose alteplase in patients who participated in the alteplase-dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).
Source: Journal of the Neurological Sciences - January 11, 2018 Category: Neurology Authors: Guofang Chen, Xia Wang, Thompson G. Robinson, Richard I. Lindley, Shengkui Zhou, Lei Ping, Weiwei Liu, Leijing Liu, John Chalmers, Craig S. Anderson, for the ENCHANTED Investigators Source Type: research
Administration of a pictorial questionnaire to screen for stroke among patients with hypertension or diabetes in rural Ghana
Stroke prevention is an important public health goal in low-and-middle income countries (LMIC) due to its high mortality and morbidity in these settings. Epidemiological data from high-income countries have demonstrated a potent predictive association between self-reported stroke symptoms and risks of future strokes, incident cognitive impairment and all-cause mortality.
Source: Journal of the Neurological Sciences - January 6, 2017 Category: Neurology Authors: Fred S. Sarfo, Rexford Adu Gyamfi, Sheila Adamu, Osei Sarfo-Kantanka, Mayowa Owolabi, Bruce Ovbiagele Source Type: research
Feasibility study of a targeted self-management intervention for reducing stroke risk factors in a high-risk population in Uganda
Stroke remains a global concern due to increasing lifespan, patterns of industrialization, adoption of harmful western diets, and an increasing prevalence of risk factors such as hypertension, obesity, and diabetes. We investigated an adopted novel self-management intervention, TargetEd mAnageMent Intervention (TEAM) to reduce modifiable stroke risk factors in Uganda.
Source: Journal of the Neurological Sciences - January 4, 2018 Category: Neurology Authors: Mark Kaddumukasa, Jane Nakibuuka, Levicatus Mugenyi, Olivia Namusoke, Bryan Kabaala, Carol Blixen, Elly Katabira, Anthony Furlan, Martha Sajatovic, Doreen Birungi Source Type: research
Incident stroke among Ghanaians with hypertension and diabetes: A multicenter, prospective cohort study
The burden of stroke among hypertensive and diabetic population in sub-Saharan Africa remains high. We sought to identify the risk factors associated with stroke occurrence in these high-risk population groups.
Source: Journal of the Neurological Sciences - September 13, 2018 Category: Neurology Authors: Fred S. Sarfo, Linda M. Mobula, Jacob Plange-Rhule, Daniel Ansong, David Ofori-Adjei Source Type: research
