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Prognosis of Intracerebral Hemorrhage with Newly Diagnosed Diabetes Mellitus According to Hemoglobin A1c Criteria
Hemoglobin A1c (HbA1c) has been recommended for diagnosing diabetes mellitus (DM). We aimed to assess the prevalence of newly diagnosed diabetes mellitus (NDDM) in patients with intracerebral hemorrhage (ICH) using HbA1c criteria and to investigate the long-term prognosis of patients with ICH with NDDM.
Source: Journal of Stroke and Cerebrovascular Diseases - February 19, 2018 Category: Neurology Authors: Xinmiao Zhang, Jing Jing, Huaguang Zheng, Qian Jia, Xingquan Zhao, Liping Liu, Chunxue Wang, Xia Meng, Yuesong Pan, Yilong Wang, Yongjun Wang, Investigators for ACROSS-China Source Type: research

Late Transient Contrast-Induced Encephalopathy after Percutaneous Coronary Intervention
Cerebrovascular events are a recognized complication of cardiac catheterization, with various neurological symptoms. The incidence is estimated to be .3%-.4%.1 A much more infrequent complication is a contrast-induced encephalopathy (CIE) described about 50 cases in the literature. The pathogenesis is believed to be a direct neurotoxic effect causing an osmotic disruption of the blood –brain barrier.2,3 Risk factors are hypertension, diabetes mellitus, renal impairment, large volumes of contrast, and previous adverse reaction to iodinated contrast.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2018 Category: Neurology Authors: Andreas Eleftheriou, Avan Sabir Rashid, Fredrik Lundin Tags: Case Studies Source Type: research

Risk Factors of Intracerebral Hemorrhage: A Case-Control Study
Background: Hypertension is a well-known risk factor for intracerebral hemorrhage (ICH). On many of the other potential risk factors, such as smoking, diabetes, and alcohol intake, results are conflicting. We assessed risk factors of ICH, taking also into account prior depression and fatigue. Methods: This is a population-based case-control study of 250 primary ICH patients, conducted in Helsinki University Hospital, Finland. The controls (n  = 750) were participants of the FINRISK study, a large Finnish population survey on risk factors of chronic noncommunicable diseases, matched with cases by sex and age.
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2020 Category: Neurology Authors: Hanne Sallinen, Arto Pietil ä, Veikko Salomaa, Daniel Strbian Source Type: research

Bilateral posterior infarction in a SARS-Cov-2 infected patient: discussion about an unusual case
We present a case of bilateral occipito-temporal infarction revealed by a sudden cortical blindness with haemorrhagic transformation after intravenous thrombolysis in a diabetic patient infected by Covid-19. Differential diagnoses are discussed in front of this unusual presentation and evolution.
Source: Journal of Stroke and Cerebrovascular Diseases - June 27, 2020 Category: Neurology Authors: Claire Bonardel, Mathieu Bonnerot, Marie Ludwig, Wilfried Vadot, Gaspard Beaune, Bruno Chanzy, Lucie Cornut, H élène Baysson, Magali Farines, Isabelle Combes, Gabriel Macheda, Fabrice Bing Tags: Case Report Source Type: research

Bilateral posterior cerebral artery territory infarction in a SARS-Cov-2 infected patient: discussion about an unusual case
We present a case of bilateral occipito-temporal infarction revealed by a sudden cortical blindness with haemorrhagic transformation after intravenous thrombolysis in a diabetic patient infected by Covid-19. Differential diagnoses are discussed in front of this unusual presentation and evolution.
Source: Journal of Stroke and Cerebrovascular Diseases - June 27, 2020 Category: Neurology Authors: Claire Bonardel, Mathieu Bonnerot, Marie Ludwig, Wilfried Vadot, Gaspard Beaune, Bruno Chanzy, Lucie Cornut, H élène Baysson, Magali Farines, Isabelle Combes, Gabriel Macheda, Fabrice Bing Tags: Case Report Source Type: research

Renal-Cerebral Pathophysiology: The Interplay Between Chronic Kidney Disease and Cerebrovascular Disease
Cerebrovascular disease has increasingly been linked to overall vascular health. Pathologic conditions like diabetes, hypertension, and kidney disease have been shown to affect brain health and cerebrovascular and nervous systems. Acute kidney injury (AKI) and chronic Kidney Disease (CKD) represent a variety of vascular insults that can adversely affect cerebral health. Hypertension, fluctuations in blood pressure, and diabetic vasculopathy are known risk factors for cerebrovascular disease associated with CKD.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2020 Category: Neurology Authors: Ramy M Hanna, Antoney Ferrey, Connie M Rhee, Kamyar Kalantar-Zadeh Source Type: research

Protective Effect of Eichhornia Crassipes Against Cerebral Ischemia Reperfusion Injury in Normal and Diabetic rats
Eichhornia crassipes (EC) is well reported to modify inflammatory response, oxidative stress which are key pathophysiological finding of cerebral reperfusion injury, alongside it is reported to reduce cholesterol and blood glucose levels, and therefore present work was designed to investigate the effect of EC on cerebral reperfusion injury in normal and diabetic rats. Each protocol comprised cerebral ischemia (CI) for 30 min followed by reperfusion(R) for 1  h. Animals were treated with EC (100 mg/kg p.o) for seven days.
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Vashisth Bhavsar, Jitendra Vaghasiya, B N Suhagia, Priyanshu Thaker Source Type: research

Glycemic Gap Predicts in-Hospital Mortality in Diabetic Patients with Intracerebral Hemorrhage
The relationship between admission hyperglycemia and intracerebral hemorrhage (ICH) outcome remains controversial. Glycemic gap (GG) is a superior indicator of glucose homeostatic response to physical stress compared to admission glucose levels. We aimed to evaluate the association between GG and in-hospital mortality in ICH.
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2021 Category: Neurology Authors: Elaheh Zarean, Simona Lattanzi, Mehdi Azizmohammad Looha, Mario Di Napoli, Sherry H-Y Chou, Alibay Jafarli, Michel Torbey, Afshin A Divani Source Type: research

Association of Carotid Plaques and Common Carotid Intima-media Thickness with Modifiable Cardiovascular Risk Factors
Most interventions for the treatment or prevention of atherosclerosis are focused in modifiable traditional cardiovascular risk factors (CVRF), such as smoking, diabetes mellitus, hypertension, and hypercholesterolemia.1 However, there are numerous approaches for the detection and measurement of subclinical atherosclerosis. The B-mode ultrasound examination is arguably one of the best methods for detecting early stages of atherosclerotic disease in the carotid arteries.2 Assessments of atherosclerosis using carotid ultrasound imaging include carotid intima-media thickness (IMT) measurement and plaque detection.
Source: Journal of Stroke and Cerebrovascular Diseases - February 23, 2021 Category: Neurology Authors: Pedro J. Santos-Neto, Eduardo H. Sena-Santos, Danilo P. Meireles, M árcio Sommer Bittencourt, Itamar S. Santos, Isabela M. Bensenor, Paulo A. Lotufo Source Type: research

Detection of Early Vascular Atherosclerosis in Type 2 Diabetes Mellitus Using Ultrasound Radiofrequency-Data Technique
To quantitatively evaluate changes in vascular elasticity and intima-media thickness (IMT) of the common carotid artery (CCA) with Ultrasound radiofrequency (RF)-data technology in asymptomatic patients with type-2 diabetes mellitus (T2DM) and controls.
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2021 Category: Neurology Authors: Hai-Jun Dan, Hong Ji, Ya-Qing Zhou, Cai-Ying Li, Bu-Lang Gao Source Type: research

Sodium-Glucose Co-Transporter-2 Inhibitors Decrease the Odds for Atrial Fibrillation in Subjects with Heart Failure
Ong et al. have shown in their very informative, recently published meta-analysis that sodium-glucose co-transporter-2 (SGLT-2) inhibitors result in a significant decrease in the odds for atrial fibrillation (AF) regardless of status of diabetes mellitus or cardiovascular disease at baseline.1 However, the authors failed to show that this effect is sustained in subjects with heart failure (HF).1
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2021 Category: Neurology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Michael Doumas Tags: Letter to the Editor Source Type: research

Taking the Obesity Paradox to New Heights in Cerebral Atherosclerosis
Obesity typically worsens many of the major cardiovascular disease (CVD) risk factors, such as elevating blood pressure, worsening dyslipidemia, increasing impaired plasma glucose metabolism (leading to metabolic syndrome and diabetes mellitus), and increasing systemic inflammation, increasing the risk of most CVD, including hypertension, coronary heart disease (CHD), heart failure, atrial fibrillation and cerebrovascular diseases.1 –3 However, in patients with established CVD, many studies published by my colleagues and I and others have demonstrated a consistent paradox, where obese patients with established CVD seem t...
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2022 Category: Neurology Authors: Carl J. Lavie, Salvatore Carbone, Ian J. Neeland Tags: Editorial Source Type: research

Skin capillary amylin deposition resembles brain amylin vasculopathy in rats
Human amylin is a 37 amino-acid pancreatic peptide that forms neuro-toxic aggregates that deposit in the endothelium of brain capillaries of patients with diabetes, potentially contributing to cerebral small vessel ischemic injury. Pathogenic amylin also deposits in the capillary endothelium in other organs, including the skin. The aim of this study was to test the hypothesis that skin capillary amylin deposition correlates with cerebral small vessel amylin deposition, potentially providing a clinically useful marker of cerebral amylin deposition.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2023 Category: Neurology Authors: Saurav Das, Nirmal Verma, Larry B. Goldstein, Florin Despa Source Type: research

Perivascular spaces mediate a relationship between diabetes and other cerebral small vessel disease markers in cerebrovascular and neurodegenerative diseases
Cerebral small vessel disease (SVD) is used to describe heterogeneous pathological changes in perforating arterioles, venules, and capillaries that supply blood to subcortical structures.1 These pathological changes manifest on magnetic resonance imaging (MRI) as quantifiable volumetric measures. Established markers of SVD identified on MRI include deep white matter hyperintensities (dWMH) and periventricular white matter hyperintensities (pWMH) of presumed vascular origin and lacunes, and MRI visible enlarged perivascular spaces (PVS) in the white matter (wmPVS) or basal ganglia (bgPVS).
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2023 Category: Neurology Authors: Julia Zebarth, Radia Kamal, George Perlman, Michael Ouk, Lisa Y. Xiong, Di Yu, William Z. Lin, Joel Ramirez, Mario Masellis, Maged Goubran, Bradley J. MacIntosh, Sandra E. Black, Hugo Cogo-Moreira, Christopher J.M. Scott, Robert Bartha, Sean Symons, Seyye Source Type: research

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