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Source: Circulation
Condition: Diabetes

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Total 147 results found since Jan 2013.

Incident Type 2 Myocardial Infarction in a Cohort of Patients Undergoing Coronary or Peripheral Arterial Angiography.
CONCLUSIONS: -T2MI is common and associated with poor prognosis. Studies evaluating treatment strategies for management of T2MI are needed.Clinical Trial Registration -https://clinicaltrials.gov/ct2/show/NCT00842868, Clinical Trials.Gov # NCT00842868. PMID: 27881568 [PubMed - as supplied by publisher]
Source: Circulation - November 20, 2016 Category: Cardiology Authors: Gaggin HK, Liu Y, Lyass A, van Kimmenade RR, Motiwala SR, Kelly N, Mallick A, Gandhi PU, Ibrahim NE, Simon M, Bhardwaj A, Belcher A, Harisiades JE, Massaro JM, D'Agostino RB, Januzzi JL Tags: Circulation Source Type: research

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients with Type 2 Diabetes: 10-year Follow-up of a Randomized Controlled Trial.
CONCLUSIONS: -Low-dose aspirin did not affect the risk for cardiovascular events, but increased risk for gastrointestinal bleeding in patients with type 2 diabetes in a primary prevention setting. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00110448. PMID: 27881565 [PubMed - as supplied by publisher]
Source: Circulation - November 14, 2016 Category: Cardiology Authors: Saito Y, Okada S, Ogawa H, Soejima H, Sakuma M, Nakayama M, Doi N, Jinnouchi H, Waki M, Masuda I, Morimoto T, JPAD Trial Investigators Tags: Circulation Source Type: research

Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association.
in the Young; Council on Clinical Cardiology; and Stroke Council Abstract Sleep is increasingly recognized as an important lifestyle contributor to health. However, this has not always been the case, and an increasing number of Americans choose to curtail sleep in favor of other social, leisure, or work-related activities. This has resulted in a decline in average sleep duration over time. Sleep duration, mostly short sleep, and sleep disorders have emerged as being related to adverse cardiometabolic risk, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. Here, we review the ev...
Source: Circulation - September 18, 2016 Category: Cardiology Authors: St-Onge MP, Grandner MA, Brown D, Conroy MB, Jean-Louis G, Coons M, Bhatt DL, American Heart Association Obesity, Behavior Change, Diabetes, and Nutrition Committees of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease Tags: Circulation Source Type: research

Added Sugars and Cardiovascular Disease Risk in Children: A Scientific Statement From the American Heart Association.
CONCLUSIONS: Associations between added sugars and increased cardiovascular disease risk factors among US children are present at levels far below current consumption levels. Strong evidence supports the association of added sugars with increased cardiovascular disease risk in children through increased energy intake, increased adiposity, and dyslipidemia. The committee found that it is reasonable to recommend that children consume ≤25 g (100 cal or ≈6 teaspoons) of added sugars per day and to avoid added sugars for children <2 years of age. Although added sugars most likely can be safely consumed in low amounts as ...
Source: Circulation - August 21, 2016 Category: Cardiology Authors: Vos MB, Kaar JL, Welsh JA, Van Horn LV, Feig DI, Anderson CA, Patel MJ, Cruz Munos J, Krebs NF, Xanthakos SA, Johnson RK, American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Clinical Cardiology Tags: Circulation Source Type: research

Return to the Workforce Following First Hospitalization for Heart Failure: A Danish Nationwide Cohort Study.
CONCLUSIONS: -Patients in the workforce prior to HF hospitalization had low mortality but high risk of detachment from the workforce one year later. Young age, male sex, and higher level of education were predictors of return to work. PMID: 27507406 [PubMed - as supplied by publisher]
Source: Circulation - August 8, 2016 Category: Cardiology Authors: Rørth R, Wong C, Kragholm K, Fosbøl E, Mogensen UM, Lamberts M, Petrie MC, Jhund PS, Gerds TA, Torp-Pedersen C, Gislason GH, McMurray JJ, Køber L, Kristensen SL Tags: Circulation Source Type: research

Assessing Optimal Blood Pressure in Patients with Asymptomatic Aortic Valve Stenosis: The SEAS Study.
CONCLUSIONS: -Optimal BP seems to be systolic 130-139 mmHg and diastolic 70-90 mmHg in these patients with asymptomatic AS and no manifest atherosclerotic disease or diabetes. Clinical Trial Registration-http://www.clinicaltrials.gov; NCT00092677. PMID: 27486164 [PubMed - as supplied by publisher]
Source: Circulation - August 1, 2016 Category: Cardiology Authors: Nielsen OW, Sajadieh A, Sabbah M, Greve AM, Olsen MH, Boman K, Nienaber CA, Kesäniemi YA, Pedersen TR, Willenheimer R, Wachtell K Tags: Circulation Source Type: research

Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes: Cardiovascular and Kidney Effects, Potential Mechanisms and Clinical Applications.
Abstract Sodium glucose co-transporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin and canagliflozin, are now widely approved anti-hyperglycemic therapies. Due to their unique glycosuric mechanism, SGLT2 inhibitors also reduce weight. Perhaps more importantly are osmotic diuretic and natriuretic effects contributing to plasma volume contraction, and decreases in systolic and diastolic blood pressures (BP) by 4-6/1-2 mmHg, respectively, which may underlie cardiovascular and kidney benefits. SGLT2 inhibition is also associated with an acute, dose-dependent reduction in eGFR by ~5 ml/min/1.73m(2) and...
Source: Circulation - July 27, 2016 Category: Cardiology Authors: Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ Tags: Circulation Source Type: research

Atherothrombotic Risk Stratification and the Efficacy and Safety of Vorapaxar in Patients with Stable Ischemic Heart Disease and Prior Myocardial Infarction.
CONCLUSIONS: -Stratification of baseline atherothrombotic risk can assist with therapeutic decision-making regarding vorapaxar use for secondary prevention after MI. Clinical Trial Registration-http://www.clinicaltrials.gov; NCT00526474. PMID: 27440003 [PubMed - as supplied by publisher]
Source: Circulation - July 19, 2016 Category: Cardiology Authors: Bohula EA, Bonaca MP, Braunwald E, Aylward PE, Corbalan R, De Ferrari GM, He P, Lewis BS, Merlini PA, Murphy SA, Sabatine MS, Scirica BM, Morrow DA Tags: Circulation Source Type: research

Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention.
CONCLUSIONS: -OSA is independently associated with subsequent MACCE in patients undergoing PCI. Evaluation of therapeutic approaches to mitigate OSA-associated risk is warranted. Clinical Trial Registration Information-ClinicalTrials.gov. Identifier: NCT01306526. PMID: 27178625 [PubMed - as supplied by publisher]
Source: Circulation - May 12, 2016 Category: Cardiology Authors: Lee CH, Sethi R, Li R, Ho HH, Hein T, Jim MH, Loo G, Koo CY, Gao XF, Chandra S, Yang XX, Furlan SF, Ge Z, Mundhekar A, Zhang WW, Uchôa CH, Kharwar RB, Chan PF, Chen SL, Chan MY, Richards A, Tan HC, Ong TH, Roldan G, Tai BC, Drager LF, Zhang JJ Tags: Circulation Source Type: research

The Heart of 25 by 25: Achieving the Goal of Reducing Global and Regional Premature Deaths From Cardiovascular Diseases and Stroke: A Modeling Study From the American Heart Association and World Heart Federation.
Abstract In 2011, the United Nations set key targets to reach by 2025 to reduce the risk of premature noncommunicable disease death by 25% by 2025. With cardiovascular disease being the largest contributor to global mortality, accounting for nearly half of the 36 million annual noncommunicable disease deaths, achieving the 2025 goal requires that cardiovascular disease and its risk factors be aggressively addressed. The Global Cardiovascular Disease Taskforce, comprising the World Heart Federation, American Heart Association, American College of Cardiology Foundation, European Heart Network, and European Society o...
Source: Circulation - May 8, 2016 Category: Cardiology Authors: Sacco RL, Roth GA, Reddy KS, Arnett DK, Bonita R, Gaziano TA, Heidenreich PA, Huffman MD, Mayosi BM, Mendis S, Murray CJ, Perel P, Piñeiro DJ, Smith SC, Taubert KA, Wood DA, Zhao D, Zoghbi WA Tags: Circulation Source Type: research

Global Electrical Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies.
CONCLUSIONS: -Abnormal electrophysiological substrate quantified by GEH parameters is independently associated with SCD in the general population. Addition of GEH parameters to clinical characteristics improves SCD risk prediction. PMID: 27081116 [PubMed - as supplied by publisher]
Source: Circulation - April 13, 2016 Category: Cardiology Authors: Waks JW, Sitlani CM, Soliman EZ, Kabir M, Ghafoori E, Biggs ML, Henrikson CA, Sotoodehnia N, Biering-Sørensen T, Agarwal SK, Siscovick DS, Post WS, Solomon SD, Buxton AE, Josephson ME, Tereshchenko LG Tags: Circulation Source Type: research

Diabetes Mellitus and Prevention of Late Myocardial Infarction After Coronary Stenting in the Randomized Dual Antiplatelet Therapy Study.
CONCLUSIONS: -In patients with DM, continued thienopyridine beyond 1-year after coronary stenting is associated with reduced risk of MI, although this benefit is attenuated when compared with patients without DM. Clinical Trial Registration Information-ClinicalTrials.gov. Identifier: NCT00977938. PMID: 26994121 [PubMed - as supplied by publisher]
Source: Circulation - March 18, 2016 Category: Cardiology Authors: Meredith IT, Tanguay JF, Kereiakes DJ, Cutlip DE, Yeh RW, Garratt KN, Lee DP, Steg PG, Weaver WD, Holmes DR, Brindis RG, Trebacz J, Massaro JM, Hsieh WH, Mauri L, DAPT Study Investigators Tags: Circulation Source Type: research

Relative Lack of Culprit and Obstructive Coronary Lesions in Patients with Acute Ischemic Stroke and Elevated Cardiac Troponin.
Abstract The measurement of cardiac troponins (cTn) is widely used to diagnose myocardial injury or necrosis(1, 2), and has become an important tool for the risk stratification and clinical management of patients with acute coronary syndrome (ACS)(3, 4). However, elevated cTn levels are also found in non-ACS patients(5). For example, in a recent study of patients with chronic stable coronary artery disease, higher cTn levels were observed in patients with concomitant kidney disease or diabetes mellitus (6, 7). Furthermore, approximately 15% of patients with acute ischemic stroke have elevated cTn(8-11); many of wh...
Source: Circulation - March 1, 2016 Category: Cardiology Authors: Hofmann Bowman MA, Liao JK Tags: Circulation Source Type: research

Prediction of First Cardiovascular Disease Event in Type 1 Diabetes: The Steno T1 Risk Engine.
CONCLUSIONS: -This high performing CVD risk model allows the implementation of decision rules in a clinical setting. PMID: 26888765 [PubMed - as supplied by publisher]
Source: Circulation - February 17, 2016 Category: Cardiology Authors: Vistisen D, Andersen GS, Hansen CS, Hulman A, Henriksen JE, Beck-Nielsen H, Jørgensen ME Tags: Circulation Source Type: research

Epidemiology and Mechanisms of Uremia-Related Cardiovascular Disease.
Abstract Patients with chronic kidney disease and end-stage renal disease are at 5- to 10-fold higher risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically, CVD in this population manifests as coronary artery disease, arrhythmias, stroke, or congestive heart failure. Beyond the traditional risk factors (eg, diabetes mellitus and hypertension), uremia-specific factors that arise from accumulating toxins also contribute to the pathogenesis of CVD. In this review, we summarize the literature on the epidemiology of both traditional and uremia-related CVD and focus on postulated mechani...
Source: Circulation - February 2, 2016 Category: Cardiology Authors: Tonelli M, Karumanchi SA, Thadhani R Tags: Circulation Source Type: research