• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes
Conclusions/interpretationThere is a dose-dependent association between smoking and cardiovascular disease in individuals with type 1 diabetes. In men in particular, the risk of incident stroke remains high even after smoking cessation and is increased in current and former smokers independently of other risk factors.
Source: Diabetologia - November 5, 2018 Category: Endocrinology Source Type: research

Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21  years of follow-up in the randomised Steno-2 Study
Conclusions/interpretationIntensified multiple risk factor intervention in patients with type 2 diabetes and microalbuminuria reduces the risk for strokes as well as the number of recurrent cerebrovascular events.Trial registrationClinicalTrials.gov NCT00320008.
Source: Diabetologia - May 31, 2019 Category: Endocrinology Source Type: research

Urinary liver-type fatty acid binding protein is an independent predictor of stroke and mortality in individuals with type 1 diabetes
Conclusions/interpretationUrinary L-FABP is an independent predictor of stroke and mortality in individuals with type 1 diabetes.
Source: Diabetologia - August 10, 2017 Category: Endocrinology Source Type: research

Family history of myocardial infarction, stroke and diabetes and cardiometabolic markers in children
Conclusions/interpretation One-third of the children had a strong family history of CVD and/or diabetes. These children had higher TC levels and TC/HDLC ratios than children with no family history. A strong family history of MI or diabetes was independently associated with unfavourable cardiometabolic markers specific to those diseases.
Source: Diabetologia - July 1, 2016 Category: Endocrinology Source Type: research

Ideal cardiovascular health, glycaemic status and incident type 2 diabetes mellitus: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study
Conclusions/interpretationA higher number of ideal CVH components was associated with a dose-dependent lower risk of diabetes for participants with normal fasting glucose but not IFG. Tailored efforts that take into account observed differences by race and glycaemic level are needed for the primordial prevention of diabetes.
Source: Diabetologia - January 15, 2019 Category: Endocrinology Source Type: research

Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes
Conclusions/interpretationArteriolar tortuosity and fractal dimension were associated with incident cerebrovascular events, independent of a wide range of traditional cardiovascular risk factors including diabetic retinopathy. These findings suggest potential for measurements of early retinal vasculature change to aid in the identification of people with type 2 diabetes who are at increased risk from stroke.Graphical abstract
Source: Diabetologia - September 8, 2021 Category: Endocrinology Source Type: research

Nordic dietary patterns and cardiometabolic outcomes: a systematic review and meta-analysis of prospective cohort studies and randomised controlled trials
Conclusions/interpretationAdherence to Nordic dietary patterns is associated with generally small important reductions in the risk of major CVD outcomes and diabetes, which are supported by similar reductions in LDL-cholesterol and other intermediate cardiometabolic risk factors. The available evidence provides a generally good indication of the likely benefits of Nordic dietary patterns in people with or at risk for diabetes.RegistrationClinicalTrials.gov NCT04094194.FundingDiabetes and Nutrition Study Group of the EASD Clinical Practice.Graphical abstract
Source: Diabetologia - August 26, 2022 Category: Endocrinology Source Type: research

Association of the average rate of change in HbA 1c with severe adverse events: a longitudinal evaluation of audit data from the Bavarian Disease Management Program for patients with type 2 diabetes mellitus
Conclusions/interpretation In patients newly started on insulin therapy, rapid and higher HbA1c variability is associated with an increased risk of myocardial infarction, stroke, severe hypoglycaemia and emergency admission.
Source: Diabetologia - January 13, 2016 Category: Endocrinology Source Type: research

Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes
Conclusions/interpretationThere remains uncertainty about whether metformin reduces risk of cardiovascular disease among patients with type 2 diabetes, for whom it is the recommended first-line drug. Although this is mainly due to absence of evidence, it is unlikely that a definitive placebo-controlled cardiovascular endpoint trial among people with diabetes will be forthcoming. Alternative approaches to reduce the uncertainty include the use of electronic health records in long-term pragmatic evaluations, inclusion of metformin in factorial trials, publication of cardiovascular outcome data from adverse event reporting in...
Source: Diabetologia - August 2, 2017 Category: Endocrinology Source Type: research

Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: analysis of ALTITUDE trial
Conclusions/interpretationWe identified three questions from the MNSI that provide additional prognostic information for individuals with type 2 diabetes and CKD and/or CVD. If externally validated, these questions may be integrated into the clinical history to augment prediction of CV events in high-risk individuals with type 2 diabetes.
Source: Diabetologia - November 3, 2017 Category: Endocrinology Source Type: research

Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes
Conclusions/interpretationHigher omentin concentrations are associated with an increased risk for cardiovascular events in individuals with diabetes after adjustment for multiple cardiovascular risk factors. Given data from preclinical studies, it appears possible that this association reflects a compensatory, but insufficient upregulation of omentin concentrations as a response to stimuli that increase cardiovascular risk.
Source: Diabetologia - November 8, 2019 Category: Endocrinology Source Type: research

The efficacy and safety of novel classes of glucose-lowering drugs for cardiovascular outcomes: a network meta-analysis of randomised clinical trials
Conclusions/interpretationSGLT2i and GLP-1RA are superior to DPP-4i in terms of CV and renal outcomes. GLP-1RA is the only drug class that reduces the risk of stroke. SGLT2i is superior in reducing HHF and renal outcomes. Therefore, the choice between SGLT2i and GLP-1RA should be individualised according to patient profiles.PROSPERO registration number: CRD42020206600.Graphical abstract
Source: Diabetologia - November 2, 2021 Category: Endocrinology Source Type: research

Pages: 1  2  3  4