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Plasma stem cell factor levels are associated with risk of cardiovascular disease and death
ConclusionsThis prospective population‐based study demonstrates that subjects with high levels of SCF have a lower risk of cardiovascular events and death. The findings provide clinical support for a protective role of SCF in maintaining cardiovascular integrity.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - August 26, 2017 Category: Internal Medicine Authors: Harry Bj örkbacka, Ingrid Yao Mattisson, Maria Wigren, Olle Melander, Gunilla Nordin Fredrikson, Eva Bengtsson, Isabel Gonçalves, Peter Almgren, Jens O. Lagerstedt, Marju Orho‐Melander, Gunnar Engström, Jan Nilsson Tags: Original Source Type: research

Glycaemic control and excess risk of ischaemic and haemorrhagic stroke in patients with type 1 diabetes: a cohort study of 33 453 patients
ConclusionsIndividuals with type 1 diabetes have an increased risk of ischaemic and haemorrhagic stroke, increasing markedly with poor glycaemic control.
Source: Journal of Internal Medicine - November 30, 2016 Category: Internal Medicine Authors: C. Hed én Ståhl, M. Lind, A.‐M. Svensson, S. Gudbjörnsdottir, A. Mårtensson, A. Rosengren Tags: Original Article Source Type: research

Potential health hazards of eating red meat
Abstract Red meat (beef, veal, pork, lamb and mutton) consumption contributes several important nutrients to the diet, for example essential amino acids, vitamins (including B12) and minerals (including iron and zinc). Processed red meat (ham, sausages, bacon, frankfurters, salami, etc.) undergoes treatment (curing, smoking, salting or the use of chemical preservatives and additives) to improve its shelf life and/or taste. During recent decades, consumption of red meat has been increasing globally, especially in developing countries. At the same time, there has been growing evidence that high consumption of red meat, espec...
Source: Journal of Internal Medicine - August 31, 2016 Category: Internal Medicine Authors: A. Wolk Tags: Review Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short ‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - May 2, 2016 Category: Internal Medicine Authors: M. W ürtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - April 30, 2016 Category: Internal Medicine Authors: M. Würtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

A tailored treatment strategy: a modern approach for stroke prevention in patients with atrial fibrillation
The objective of this review is to provide an overview of modern AF stroke prevention with a focus on tailored treatment strategies. Biomarkers and genetic factors have been proposed to help identify ‘high‐risk’ patients to be targeted for oral anticoagulation, but ultimately their use must be balanced against that of more simple and practical considerations for everyday use. Current guidelines have directed focus on initial identification of ‘truly low‐risk’ patients with AF, that is those patients with a CHA2DS2‐VASc [congestive heart failure, hypertension, age ≥75 years (two points), diabetes mellitus, ...
Source: Journal of Internal Medicine - March 21, 2016 Category: Internal Medicine Authors: G. Y. H. Lip, T. Potpara, G. Boriani, C. Blomström‐Lundqvist Tags: Review Source Type: research

Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross‐sectional study
ConclusionsMeasures of atherosclerotic burden are associated with clinically manifest CVD in subjects with T2D. In addition, vascular changes that are not directly related to known metabolic risk factors are important in the development of both atherosclerosis and CVD in T2D. A better understanding of the mechanisms involved is crucial for enabling better identification of CVD risk in T2D.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - March 9, 2015 Category: Internal Medicine Authors: Angela C. Shore, Helen M. Colhoun, Andrea Natali, Carlo Palombo, Gerd Östling, Kunihiko Aizawa, Cecilia Kennbäck, Francesco Casanova, Margaretha Persson, Kim Gooding, Phillip E. Gates, Faisel Kahn, Helen C. Looker, Fiona Adams, Jill Belch, Silvia Pinnol Tags: Original Article Source Type: research

The emerging role of microRNAs in cardiovascular disease
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - August 27, 2014 Category: Internal Medicine Authors: Lars Maegdefessel Tags: Review Source Type: research

Soluble urokinase plasminogen activator receptor levels are elevated and associated with complications in patients with type 1 diabetes
ConclusionThe suPAR level is higher in patients with type 1 diabetes, and is associated with diabetes duration and complications independent of other risk factors. suPAR is a potential novel risk marker for the management of diabetes.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - May 15, 2014 Category: Internal Medicine Authors: Simone Theilade, Stig Lyngbæk, Tine W. Hansen, Jesper Eugen‐Olsen, Mogens Fenger, Peter Rossing, Jørgen L. Jeppesen Tags: Original Source Type: research

Medical management of critical limb ischaemia: where do we stand today?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - June 26, 2013 Category: Internal Medicine Authors: Matthew A. Lambert, Jill J. F. Belch Tags: Review Source Type: research

Review of the key results from the Swedish Obese Subjects (SOS) trial – a prospective controlled intervention study of bariatric surgery
Abstract Obesity is a risk factor for diabetes, cardiovascular disease events, cancer and overall mortality. Weight loss may protect against these conditions, but robust evidence for this has been lacking. The Swedish Obese Subjects (SOS) study is the first long‐term, prospective, controlled trial to provide information on the effects of bariatric surgery on the incidence of these objective endpoints. The SOS study involved 2010 obese subjects who underwent bariatric surgery [gastric bypass (13%), banding (19%) and vertical banded gastroplasty (68%)] and 2037 contemporaneously matched obese control subjects receiving usu...
Source: Journal of Internal Medicine - February 8, 2013 Category: Internal Medicine Authors: L. Sjöström Tags: Review Source Type: research