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Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease Clinical Sciences
Conclusions—Our Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Pancreatic {beta}-Cell Function and Prognosis of Nondiabetic Patients With Ischemic Stroke Clinical Sciences
Conclusions—In this large-scale registry, β-cell dysfunction was associated with an increased risk of 12-month poor prognosis in nondiabetic patients with ischemic stroke.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Yuesong Pan, Weiqi Chen, Jing Jing, Huaguang Zheng, Qian Jia, Hao Li, Xingquan Zhao, Liping Liu, Yongjun Wang, Yan He, Yilong Wang Tags: Diabetes, Type 2, Secondary Prevention, Ischemic Stroke Original Contributions Source Type: research

Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke Clinical Sciences
We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke.Methods—We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990–1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders.Results—During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potentia...
Source: Stroke - June 26, 2017 Category: Neurology Authors: Hamidreza Saber, Jayandra J. Himali, Alexa S. Beiser, Ashkan Shoamanesh, Aleksandra Pikula, Ronenn Roubenoff, Jose R. Romero, Carlos S. Kase, Ramachandran S. Vasan, Sudha Seshadri Tags: Risk Factors, Ischemic Stroke Original Contributions Source Type: research

Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Clinical Sciences
Conclusions—Insulin resistance was associated with an increased risk of death, stroke recurrence, and poor outcome but not dependence in nondiabetic patients with acute ischemic stroke.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Jing Jing, Yuesong Pan, Xingquan Zhao, Huaguang Zheng, Qian Jia, Donghua Mi, Weiqi Chen, Hao Li, Liping Liu, Chunxue Wang, Yan He, David Wang, Yilong Wang, Yongjun Wang Tags: Prognosis, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Pioglitazone for Secondary Stroke Prevention Clinical Sciences
Conclusions—Pioglitazone reduces recurrent stroke and major vascular events in ischemic stroke patients with insulin resistance, prediabetes, and diabetes mellitus.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Meng Lee, Jeffrey L. Saver, Hung-Wei Liao, Chun-Hsien Lin, Bruce Ovbiagele Tags: Cardiovascular Disease, Diabetes, Type 2, Secondary Prevention, Meta Analysis, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Insulin Resistance Intervention After Stroke Trial of Pioglitazone: Is This Perhaps the End of the Beginning? Emerging Therapy Critiques
Source: Stroke - June 26, 2016 Category: Neurology Authors: Ntaios, G., Kent, T. A. Tags: Diabetes, Type 2 Emerging Therapy Critiques Source Type: research

Carotid Intima-Media Thickness Is Associated With the Progression of Cognitive Impairment in Older Adults Clinical Sciences
Conclusions— Greater baseline CIMT was independently associated with the risk of cognitive impairment, such as MCI and dementia in elderly subjects.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Moon, J. H., Lim, S., Han, J. W., Kim, K. M., Choi, S. H., Park, K. S., Kim, K. W., Jang, H. C. Tags: Carotid Stenosis Clinical Sciences Source Type: research

Different Risk Factor Profiles for Ischemic and Hemorrhagic Stroke in Type 1 Diabetes Mellitus Clinical Sciences
Conclusions— The risk factor profile for ischemic stroke seems partly different from that of hemorrhagic stroke in patients with type 1 diabetes mellitus.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Hagg, S., Thorn, L. M., Forsblom, C. M., Gordin, D., Saraheimo, M., Tolonen, N., Waden, J., Liebkind, R., Putaala, J., Tatlisumak, T., Groop, P.-H., on behalf of the FinnDiane Study Group Tags: Risk Factors, Type 1 diabetes, Acute Cerebral Hemorrhage, Acute Cerebral Infarction Clinical Sciences Source Type: research

Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats Brief Reports
Conclusions— Early insulin glycemic control may be beneficial in combination with tPA thrombolysis for ischemic stroke with diabetes mellitus or poststroke hyperglycemia.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Fan, X., Ning, M., Lo, E. H., Wang, X. Tags: Animal models of human disease, Type 1 diabetes, Acute Cerebral Infarction, Embolic stroke, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research