Filtered By:
Condition: Diabetes
This page shows you your search results in order of relevance. This is page number 11.
Order by Relevance | Date
Total 1499 results found since Jan 2013.
TNFAIP3 is anti-inflammatory in the retinal vasculature
CONCLUSIONS: TNFAIP3 serves as an anti-inflammatory factor in the retinal vasculature. Epac1 regulates TNFAIP3. TNFAIP3 may offer a new mechanism for regulating inflammation and permeability in the retinal vasculature.PMID:36034737 | PMC:PMC9352365
Source: Molecular Vision - August 29, 2022 Category: Molecular Biology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
TRPC6 Mediates High Glucose-induced Mitochondrial Fission through Activation of CDK5 in Cultured Human Podocytes
This study was therefore aimed to explore the regulatory role and mechanisms of TRPC6 in high glucose (HG)-induced mitochondrial dysfunction in podocytes. Here we found that TRPC6 expression and TRPC6-induced Ca2+ influx were upregulated in HG-treated podocytes. Furthermore, the TRPC6 inhibitor and TRPC6 siRNA ameliorated mitochondrial dysfunction and apoptosis in HG-treated podocytes. BAPTA-AM, an intracellular calcium chelating agent, attenuated mitochondrial fission under HG conditions as well. Then, we found the activity of calpain-1 and cyclin-dependent kinase 5 (CDK5) were markedly enhanced in HG-treated podocytes, w...
Source: Frontiers in Physiology - September 21, 2022 Category: Physiology Source Type: research
TNFAIP3 is anti-inflammatory in the retinal vasculature
CONCLUSIONS: TNFAIP3 serves as an anti-inflammatory factor in the retinal vasculature. Epac1 regulates TNFAIP3. TNFAIP3 may offer a new mechanism for regulating inflammation and permeability in the retinal vasculature.PMID:36034737 | PMC:PMC9352365
Source: Molecular Vision - August 29, 2022 Category: Molecular Biology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
