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Source: Stem Cells
Condition: Dermatitis
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Total 2 results found since Jan 2013.
TGF ‐β secreted by human umbilical cord blood‐derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF‐α and IgE
This study investigated the role of transforming growth factor‐beta (TGF‐β) in the therapeutic effect of hUCB‐MSCs on AD. Small interfering RNA (siRNA)‐ mediated depletion of TGF‐β disrupted the therapeutic effect of hUCB‐MSCs in a mouse model of AD by attenuating the beneficial changes in histopathology, mast cell infiltration, tumor necrosis factor ‐alpha (TNF ‐α) expression, and the serum IgE level. To confirm that hUCB‐MSCs regulate secretion of TNF‐α, we investigated whether they inhibit TNF‐α secretion by activated LAD2 cells. Coculture with hUCB‐MSCs significantly inhibited secretion of ...
Source: Stem Cells - April 10, 2020 Category: Stem Cells Authors: Hwanhee Park,
Seunghee Lee,
Yeonsil Yu,
SaeMi Yoo,
Song Yi Baek,
Namhee Jung,
Kwang ‐Won Seo,
Kyung‐Sun Kang Tags: Translational and Clinical Research Source Type: research
