• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Pair Housing Reverses Post-Stroke Depressive Behaviour in Mice.
Abstract Social isolation (SI) has been linked epidemiologically to high rates of morbidity and mortality following stroke. In contrast, strong social support enhances recovery and lowers stroke recurrence. However, the mechanism by which social support influences stroke recovery has not been adequately explored. The goal of this study was to examine the effect of post-stroke pair housing and SI on behavioural phenotypes and chronic functional recovery in mice. Young male mice were paired for 14 days before a 60minute transient middle cerebral artery occlusion (MCAO) or sham surgery and assigned to various housing...
Source: Behavioural Brain Research - May 1, 2014 Category: Neurology Authors: Verma R, Friedler BD, Harris NM, McCullough LD Tags: Behav Brain Res Source Type: research

Social isolation after stroke leads to depressive-like behavior and decreased BDNF levels in mice.
In this study, we investigated both the sub-acute (2 weeks) and chronic (7 weeks) effects of social isolation on post-stroke functional and histological outcome. Worsened histological damage from ischemic injury and an increase in depressive-like behavior was observed in isolated mice as compared to pair-housed mice. Mice isolated immediately after stroke showed a decrease in the levels of brain-derived neurotrophic factor (BDNF). These changes, both histological and behavioral, suggest an overall negative effect of social isolation on stroke outcome, potentially contributing to post-stroke depression and anxiety. Therefor...
Source: Behavioural Brain Research - November 5, 2013 Category: Neurology Authors: O'Keefe LM, Doran SJ, Mwilambwe-Tshilobo L, Conti LH, Venna VR, McCullough LD Tags: Behav Brain Res Source Type: research

Effects of wheel-running on anxiety and depression-relevant behaviours in the MCAO mouse model of stroke: moderation of brain-derived neurotrophic factor and serotonin receptor gene expression
We report that MCAO induced hypo-locomotion and anhedonia-related behaviours, with some improvements conferred by wheel-running. Serotonin transporter gene expression was increased in the MCAO hippocampus and frontal cortex, but this increase remained despite wheel-running. Wheel-running associated up-regulation of BDNF gene expression was unaffected in MCAO mice, reflecting conservation of key neuroplasticity molecular pathways. Taken together, our results highlight the need for further research into serotonergic modulation of the affective symptoms of stroke.PMID:35777551 | DOI:10.1016/j.bbr.2022.113983
Source: Behavioural Brain Research - July 1, 2022 Category: Neurology Authors: Vanessa H Brait Katherine A Jackman Terence Y Pang Source Type: research

Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole.
Abstract We investigated the question of whether an animal model of post-stroke depression in ischemic stroke can be developed by additional chronic mild stress (CMS) procedures. Behavioral and histopathological analysis was performed for examination of the depressive disorders in CMS, left middle cerebral artery occlusion (MCAO) and CMS after MCAO (MCAO+CMS) in mice. In all depressant screening tests involving open field, sucrose preference, forced swim and Morris water maze test, MCAO+CMS mice showed more significant depressive behaviors than MCAO mice. MCAO+CMS mice also showed distinct deficits in forced swim ...
Source: Behavioural Brain Research - April 3, 2015 Category: Neurology Authors: Kim YR, Kim HN, Pak ME, Ahn SM, Hong KH, Shin HK, Choi BT Tags: Behav Brain Res Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Ramelteon improves blood-brain barrier of focal cerebral ischemia rats to prevent post-stroke depression via upregulating occludin
This study explored the effects of ramelteon with prophylactic administration on blood-brain barrier in rats with middle cerebral artery occlusion (MCAO) and the oxygen-glucose deprivation/reperfusion (OGD/R) bEnd.3 cells and found that ramelteon pretreatment improved the depressive-like behaviors and decreased infarct area in MCAO rats. Also, this study found ramelteon pretreatment improved viability and inhibited permeability in OGD/R cells. In addition, this study found that MCP-1, TNF-α, and IL-1 levels were raised in the MCAO rats and that occludin protein and mRNA levels were decreased in the MCAO and the OGD/R mode...
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Xuchen Qi Ziqi Tang Xian Shao Zhaowei Wang Mengyun Li Xiaobing Zhang Lingyan He Jianli Wang Xuebin Yu Source Type: research

Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-mediated BDNF expression
Conclusion: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.PMID:36116735 | DOI:10.1016/j.bbr.2022.114117
Source: Behavioural Brain Research - September 18, 2022 Category: Neurology Authors: Xiaoju Wang Peng Xia Jiulong Song Ting Yang Changjun Yu Kai Cheng Anliang Chen Xueping Li Source Type: research

Pages: 1  2