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Source: Frontiers in Neurology
Condition: Depression
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Total 64 results found since Jan 2013.
Train-your-brain program to reduce depression, anxiety, and stress in stroke survivors: a pilot community-based cognitive intervention study
DiscussionThe TYB program provided group support and validation, resulting in improved mood and reduced stress among stroke survivors. Cultural collectivism played a significant role in fostering group cohesion. However, the program’s limited focus on caregivers and timing of assessments during the December holidays may have affected the outcomes. The TYB program demonstrated feasibility and potential effectiveness in alleviating psychological distress and enhancing cognitive function among stroke survivors. Future research should explore long-term effects, larger sample sizes, and non-English-speaking populations to enh...
Source: Frontiers in Neurology - August 10, 2023 Category: Neurology Source Type: research
Comparative study of ultrasonic-guided betamethasone local injection and extracorporeal shock wave therapy in post-stroke hemiplegic shoulder pain: a randomized clinical trial
ConclusionThe ultrasonic-guided betamethasone local injection and extracorporeal shock wave both can improve hemiplegic shoulder pain. However, the UGLI can induce a more cytokine expression level.
Source: Frontiers in Neurology - July 19, 2023 Category: Neurology Source Type: research
Identification of a miRNA –mRNA regulatory network for post-stroke depression: a machine-learning approach
ConclusionThe study highlighted gene signatures for PSD with three genes (SPATA2, ZNF208, and YTHDC1) and four upstream miRNAs (miR-6883-5p, miR-6873-3p, miR-4776-3p, and miR-6738-3p). These biomarkers could further our understanding of the pathogenesis of PSD.
Source: Frontiers in Neurology - July 17, 2023 Category: Neurology Source Type: research
Application of vagus nerve stimulation on the rehabilitation of upper limb dysfunction after stroke: a systematic review and meta-analysis
ConclusionVNS is an effective and safe treatment for upper extremity motor dysfunction after a stroke. For the functional restoration of the upper extremities, noninvasive integrated therapy and lower-frequency VNS may be more effective. In the future, further high-quality studies with larger study populations, more comprehensive indicators, and thorough data are required to advance the clinical application of VNS.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023399820.
Source: Frontiers in Neurology - June 21, 2023 Category: Neurology Source Type: research
Predictive model, miRNA-TF network, related subgroup identification and drug prediction of ischemic stroke complicated with mental disorders based on genes related to gut microbiome
ConclusionThrough comprehensive analysis, a diagnostic prediction model with good effect was obtained. Both the training group (AUC 0.82, CI 0.93–0.71) and the verification group (AUC 0.81, CI 0.90–0.72) had a good phenotype in the qRT-PCR test. And in verification group 2 we validated between the two groups with and without carotid-related ischemic cerebrovascular events (AUC 0.87, CI 1–0.64). MiRNA (hsa-mir-129-2-3p, has-mir-335-5p, and has-mir-16-5p) and TFs (CREB1, FOXL1), which may be related to IS, were obtained.
Source: Frontiers in Neurology - May 26, 2023 Category: Neurology Source Type: research
Effects of low-frequency rTMS combined with antidepressants on depression in patients with post-stroke depression: a systematic review and meta-analysis
ConclusionThe results of this meta-analysis evidenced the efficacy and safety of low-rTMS combined with antidepressants in the treatment of depression in PSD patients. The combined therapy could reduce The depression state and the levels of IL-6 and TNF-α, and enhance the cognitive function of patients. In addition, low-rTMS had fewer adverse effects, proving safety. However, there are shortcomings, such as a lack of long-term follow-up, different intervention sites of low-rTMS, and different intervention frequencies (0.5 or 1 Hz). Thus, in the future, RCTs with a larger sample size and longer-term observation are require...
Source: Frontiers in Neurology - May 19, 2023 Category: Neurology Source Type: research
Association between hysterectomy status and stroke risk and cause-specific and all-cause mortality: evidence from the 2005 –2018 National Health and Nutrition Examination Survey
ConclusionOur study found a significant association between hysterectomy and stroke, even after adjusting for other factors that could impact risk, such as the American Heart Association (AHA)'s Life's Simple 7 cardiovascular health score and variables of age, ethnicity, marital status, income, education, and depression severity.
Source: Frontiers in Neurology - May 18, 2023 Category: Neurology Source Type: research
Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke
DiscussionBased on our results, and other recent lesion studies, we see growing evidence for a prominent role of right frontostriatal brain circuits in PSDS.
Source: Frontiers in Neurology - May 17, 2023 Category: Neurology Source Type: research
Lasting impairments following transient ischemic attack and minor stroke: a systematic review protocol
IntroductionThe focus on medical management and secondary prevention following Transient Ischemic Attack (TIA) and minor stroke is well-established. Evidence is emerging that people with TIA and minor stroke can experience lasting impairments as fatigue, depression, anxiety, cognitive impairment, and communication difficulties. These impairments are often underrecognized and inconsistently treated. Research in this area is developing rapidly and an updated systematic review is required to evaluate new evidence as it emerges. This living systematic review aims to describe the prevalence of lasting impairments and how they a...
Source: Frontiers in Neurology - May 12, 2023 Category: Neurology Source Type: research
Global research trends on COVID-19 and stroke: A bibliometric analysis
ConclusionOur bibliometric analysis provides a comprehensive overview of the current state of research on COVID-19 and stroke and highlights key areas of focus in the field. Optimizing the treatment of COVID-19-infected stroke patients and elucidating the underlying pathogenic mechanisms of COVID-19 and stroke co-morbidity are key areas of future research that will be beneficial in improving the prognosis of stroke patients during the ongoing COVID-19 epidemic.
Source: Frontiers in Neurology - April 3, 2023 Category: Neurology Source Type: research
Effect of acupuncture combined with antidepressants on post-stroke depression: A network meta-analysis of nine acupuncture therapy
ConclusionA comparison of the efficacy indicators of the nine different acupuncture therapies combined showed that moxibustion plus antidepressants, conventional acupuncture plus antidepressants and acupressure plus antidepressants were superior in the treatment of PSD. Based on the shortcomings of the existing studies, this conclusion needs to be validated by additional high-quality randomized controlled trials.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Repetitive transcranial magnetic stimulation for post-stroke depression: An overview of systematic reviews
ConclusionPatients with post-stroke depression may benefit from repetitive transcranial magnetic stimulation. However, in terms of the quality of the reports, the methodology, and the quality of the evidence, published systematic evaluations/meta-analyses are of low quality. We list the drawbacks of the current clinical trials of repetitive transcranial magnetic stimulation for post-stroke depression as well as potential therapeutic mechanisms. This information may serve as a guide for future clinical trials aiming to establish a solid foundation for the clinical efficacy of repetitive transcranial magnetic stimulation in ...
Source: Frontiers in Neurology - March 16, 2023 Category: Neurology Source Type: research
Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke
ConclusionOur machine learning analysis successfully demonstrated the ability to predict clinical outcomes after first-ever ischemic stroke and identified the leading prognostic factors that contribute to this prediction.
Source: Frontiers in Neurology - February 21, 2023 Category: Neurology Source Type: research
Nomogram including indirect bilirubin for the prediction of post-stroke depression at 3 months after mild acute ischemic stroke onset
ConclusionThe prevalence of PSD seems equally high even if the ischemic stroke is mild, which calls for great concern from clinicians. In addition, our study found that a higher level of indirect bilirubin can lower the risk of PSD. This finding may provide a potential new approach to PSD treatment. Furthermore, the nomogram including bilirubin is convenient and practical to predict PSD after MAIS onset.
Source: Frontiers in Neurology - February 8, 2023 Category: Neurology Source Type: research
Transcranial direct current stimulation for the treatment of post-stroke depression: A systematic review
ConclusionThis article simply aims at providing a comprehensive overview of the raw data reported in this field to date. Based on the current evidence, tDCS presents promising results for the treatment of PSD. Moreover, tDCS is also effective in PSD patients with aphasia or CPSP. However, an optimal stimulation protocol is needed to formulate. Thus, the development of robustly controlled, randomized, and high-quality clinical trials to further assess the utility of tDCS as a therapeutic tool for the treatment of PSD survivors is encouraged.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php...
Source: Frontiers in Neurology - January 18, 2023 Category: Neurology Source Type: research
