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Condition: Depression
Drug: Melatonin
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Total 452 results found since Jan 2013.
Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial
CONCLUSIONS: In this double-blind placebo-controlled phase III trial, melatonin did not prevent or significantly improve fatigue and other symptoms in patients with early stage breast cancer undergoing RT. The analysis, showing little evidence of an effect, at mid-recruitment, assured early termination of the trial.PMID:37699115 | DOI:10.1093/oncolo/oyad250
Source: The Oncologist - September 12, 2023 Category: Cancer & Oncology Authors: Nitai D Mukhopadhyay Adam Khorasanchi Sudeep Pandey Srinidhi Nemani Gwendolyn Parker Xiaoyan Deng Douglas W Arthur Alfredo Urdaneta Egidio Del Fabbro Source Type: research
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Arch Toxicol. 2023 Aug 19. doi: 10.1007/s00204-023-03562-9. Online ahead of print.ABSTRACTA physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor ...
Source: Archives of Toxicology - August 19, 2023 Category: Toxicology Authors: Klaudia Jomova Renata Raptova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults
CONCLUSIONS: This systematic review found that blue-light filtering spectacle lenses may not attenuate symptoms of eye strain with computer use, over a short-term follow-up period, compared to non-blue-light filtering lenses. Further, this review found no clinically meaningful difference in changes to CFF with blue-light filtering lenses compared to non-blue-light filtering lenses. Based on the current best available evidence, there is probably little or no effect of blue-light filtering lenses on BCVA compared with non-blue-light filtering lenses. Potential effects on sleep quality were also indeterminate, with included t...
Source: Cochrane Database of Systematic Reviews - August 18, 2023 Category: General Medicine Authors: Sumeer Singh Peter R Keller Ljoudmila Busija Patrick McMillan Eve Makrai John G Lawrenson Christopher C Hull Laura E Downie Source Type: research
Insomnia Management: A Review and Update
J Fam Pract. 2023 Jul;72(6 Suppl):S31-S36. doi: 10.12788/jfp.0620.ABSTRACTInsomnia is a distinct disorder that is common, yet underrecognized and undertreated in primary care. Treating insomnia has been shown to improve outcomes, including reduced risk of developing cardiovascular and mental health disorders. Insomnia is influenced by the brain's regulation of sleep and wake, which are mutually exclusive events. Insomnia should be treated as a distinct condition, even when occurring with a comorbid diagnosis such as depression or anxiety. Clinicians should implement a multimodal approach to insomnia management, including n...
Source: The Journal of Family Practice - August 7, 2023 Category: Practice Management Authors: David P Shaha Source Type: research
