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Thioredoxin-1 was Required for CREB Activity by Methamphetamine in Rat Pheochromocytoma Cells.
In this study, we found that Trx-1 was induced by METH in rat pheochromocytoma PC12 cells. Furthermore, PI3K/Akt pathway was involved in METH-induced increase of Trx-1 expression. An increase in phosphorylated cAMP response element-binding protein (CREB) was also observed after exposure of PC12 cells to METH, which was inhibited by a PI3K inhibitor, LY294002. In addition, the siRNA targeted toTrx-1 reduced the level of phosphorylated CREB by METH, suggesting Trx-1 is necessary for increased activity of CREB by METH. The results obtained in this study showed that Trx-1 might play a role in the actions of METH. PMID: 23...
Source: Cellular and Molecular Neurobiology - December 13, 2012 Category: Cytology Authors: Lv T, Wang SD, Bai J Tags: Cell Mol Neurobiol Source Type: research