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Source: Clinical and Translational Oncology
Condition: Pheochromocytoma
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Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target
ConclusionWe have demonstrated for the first time that PDK1 is overexpressed in human malignant PCC and plays an important role in the malignant biological behaviors of PC12 cell. Specifically, we have revealed that knockdown of PDK1 could attenuate activation of the Akt signaling. These data suggest that PDK1 could be a new promising potential therapeutic target in human cancer treatment for malignant PCC.
Source: Clinical and Translational Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research
