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Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research
Condition: Cystic Fibrosis
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Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR
Publication date: Available online 9 January 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Xiaofeng Li, Kin Lam Fok, Jinghui Guo, Yan Wang, Zhenqing Liu, Ziyi Chen, Chengdong Wang, Ye Chun Ruan, Sidney Siubun Yu, Hui Zhao, Ji Wu, Xiaohua Jiang, Hsiao Chang Chan Retinoic acid (RA) plays a pivotal role in many cellular processes; however, the signaling mechanisms mediating the effect of RA are not fully understood. Here, we show that RA transcriptionally upregulates cystic fibrosis transmembrane conductance regulator (Cftr) by promoting the direct binding of its receptor RARĪ± to Cftr ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 9, 2018 Category: Molecular Biology Source Type: research
