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Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Future Directions
This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications.Recent FindingsRecently, a common age-related hematological entity known as CHIP has been identified as the independent risk factor for CVD. CHIP is defined as the presence of clonally expanded blood cells involving leukemogenic mutations without the evidence of malignancy. CHIP is known to increase the...
Source: Current Oncology Reports - March 16, 2023 Category: Cancer & Oncology Source Type: research

Influence of Conventional Cardiovascular Risk Factors and Lifestyle Characteristics on Cardiovascular Disease After Hematopoietic Cell Transplantation Health Services and Outcomes
Conclusion Attention of clinicians to conventional cardiovascular risk factors and modifiable lifestyle characteristics offers hope of reducing serious cardiovascular morbidity after HCT.
Source: Journal of Clinical Oncology - January 17, 2014 Category: Cancer & Oncology Authors: Chow, Baker, Lee, Flowers, Cushing-Haugen, Inamoto, Khera, Leisenring, Syrjala, Martin Tags: Leukemia, Lymphoma, Myeloma, Outcomes Research Health Services and Outcomes Source Type: research