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Impact of obesity on cardiac metabolism, fibrosis, and function
Obesity is a global pandemic with a huge burden on the healthcare system. Obesity is not only linked to the development of risk factors for atherosclerotic vascular disease but also has a strong association with ventricular hypertrophy, heart failure, atrial fibrillation, and stroke. Recent experimental and clinical studies have demonstrated that obesity is associated with cardiac dysfunction, adipokine dysregulation, and activation of the pro-fibrotic signaling pathways leading to cardiac fibrosis, which is a key structural change responsible for atrial fibrillation.
Source: Trends in Cardiovascular Medicine - September 25, 2014 Category: Cardiology Authors: Rajiv Mahajan, Dennis H. Lau, Prashanthan Sanders Source Type: research

Impact of Obesity on Cardiac Metabolism, Fibrosis and Function
Obesity is a global pandemic with a huge burden on the health care system. Obesity is not only linked to the development of risk factors for atherosclerotic vascular disease but also has a strong association with ventricular hypertrophy, heart failure, atrial fibrillation and stroke. Recent experimental and clinical studies have demonstrated that obesity is associated with cardiac dysfunction, adipokine dysregulation and activation of the pro-fibrotic signaling pathways leading to cardiac fibrosis which is a key structural change responsible for atrial fibrillation.
Source: Trends in Cardiovascular Medicine - September 25, 2014 Category: Cardiology Authors: Rajiv Mahajan, Dennis H. Lau, Prashanthan Sanders Source Type: research