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Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
Abstract Circadian clock desynchronization has been implicated in the pathophysiology of cardiovascular disease and related risk factors (e.g., obesity, diabetes). Thus, we examined the extent to which circadian desynchronization exacerbates ischemic stroke outcomes and whether its detrimental effects on stroke severity and functional impairments are further modified by biological sex. Circadian entrainment of activity rhythms in all male and female rats was observed during exposure to a fixed light:dark (LD) 12:12 cycle but was severely disrupted when this LD cycle was routinely shifted (12hr advance/5d) for ≈ ...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F Tags: Endocrinology Source Type: research