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Specialty: Cardiology
Condition: Obesity
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Total 2621 results found since Jan 2013.
Prevention of cardiovascular disease in young adults: Focus on gender differences. A collaborative review from the EAS Young Fellows
Atherosclerosis. 2023 Sep 19:117272. doi: 10.1016/j.atherosclerosis.2023.117272. Online ahead of print.ABSTRACTA steady rise in cardiovascular morbidity and mortality has been observed in young adults within the last decades. This trend corresponds to an increasing prevalence of traditional cardiovascular risk factors such as obesity and diabetes mellitus type 2 among young adults living in developed countries. Moreover, age-specific risk factors, such as substance abuse, contraceptive medication, and pregnancy-related diseases also correlate with an increased incidence of cardiovascular diseases. In this review, we discus...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Christina Antza Antonio Gallo Chrysoula Boutari Alexandra Ershova Kadri Murat Gurses Joanna Lewek Mirakhmadjon Mirmaksudov G ünther Silbernagel Joakim Sandstedt Anna Lebedeva Source Type: research
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice
Cell Rep Med. 2023 Sep 19;4(9):101193. doi: 10.1016/j.xcrm.2023.101193.ABSTRACTIncreased liver de novo lipogenesis (DNL) is a hallmark of nonalcoholic steatohepatitis (NASH). A key enzyme controlling DNL upregulated in NASH is ATP citrate lyase (ACLY). In mice, inhibition of ACLY reduces liver steatosis, ballooning, and fibrosis and inhibits activation of hepatic stellate cells. Glucagon-like peptide-1 receptor (GLP-1R) agonists lower body mass, insulin resistance, and steatosis without improving fibrosis. Here, we find that combining an inhibitor of liver ACLY, bempedoic acid, and the GLP-1R agonist liraglutide reduces li...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Eric M Desjardins Jianhan Wu Declan C T Lavoie Elham Ahmadi Logan K Townsend Marisa R Morrow Dongdong Wang Evangelia E Tsakiridis Battsetseg Batchuluun Russta Fayyazi Jacek M Kwiecien Theodoros Tsakiridis James S V Lally Guillaume Par é Stephen L Pinkosk Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
CONCLUSION: Overall, our results indicated that plasma levels of LMWMs measured by 1H-NMR could be potential biomarkers associated with T2D. Moreover, alanine and valine can help in the early detection of the cardiovascular risk associated with this metabolic disease.PMID:37710233 | DOI:10.1186/s12933-023-01958-6
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Juan Moreno-Vedia D ídac Llop Ricardo Rodr íguez-Calvo N úria Plana N úria Amigó Roser Rosales Yaiza Esteban Josefa Girona Llu ís Masana Daiana Ibarretxe Source Type: research
Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study
CONCLUSION: Increased BMI is independently associated with augmented central arterial stiffness and reduced subendocardial perfusion but not with coronary artery disease, kidney function, or ABI.PMID:37710152 | DOI:10.1186/s12872-023-03503-5
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Nejc Piko Sebastjan Bevc Radovan Hojs Tadej Petreski Robert Ekart Source Type: research
Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease
CONCLUSION: Our findings suggest that the investigated OMLs are associated with high-risk coronary plaque features and progression over time in CVD patients.TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov. Unique identifier: NCT01621594.FUNDING: This work was supported by the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health Intramural Research Program. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript f...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Alexander V Sorokin Christin G Hong Angel M Aponte Elizabeth M Florida Jingrong Tang Nidhi Patel Irina N Baranova Haiou Li Philip M Parel Vicky Chen Sierra R Wilson Emily L Ongstad Anna Coll én Martin P Playford Thomas L Eggerman Marcus Y Chen Kazuhiko K Source Type: research
Use of Apolipoprotein B in the Era of Precision Medicine: Time for a Paradigm Change?
J Clin Med. 2023 Sep 3;12(17):5737. doi: 10.3390/jcm12175737.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and the risk of a major cardiovascular event is highest among those with established disease. Ongoing management of these patients relies on the accurate assessment of their response to any prescribed therapy, and their residual risk, in order to optimize treatment. Recent international guidelines and position statements concur that the plasma concentration of apolipoprotein B (apoB) is the most accurate measure of lipoprotein associated ASCVD risk. This is especia...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Justine Cole Rafael Zubir án Anna Wolska Ishwarlal Jialal Alan T Remaley Source Type: research
Conventional and genetic associations of adiposity with 1463 proteins in relatively lean Chinese adults
We examined the associations of adiposity with plasma levels of 1463 proteins in 3977 Chinese adults, using measured and genetically-instrumented BMI. We further used two-sample bi-directional MR analyses to assess if certain proteins influenced adiposity, along with other (e.g. enrichment) analyses to clarify possible mechanisms underlying the observed associations. Overall, the mean (SD) baseline BMI was 23.9 (3.3) kg/m2, with only 6% being obese (i.e. BMI ≥ 30 kg/m2). Measured and genetically-instrumented BMI was significantly associated at FDR < 0.05 with levels of 1096 (positive/inverse: 826/270) and 307 (positiv...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Pang Yao Andri Iona Christiana Kartsonaki Saredo Said Neil Wright Kuang Lin Alfred Pozarickij Iona Millwood Hannah Fry Mohsen Mazidi Yiping Chen Huaidong Du Derrick Bennett Daniel Avery Dan Schmidt Pei Pei Jun Lv Canqing Yu Michael Hill Junshi Chen Richar Source Type: research
Association between visceral obesity and 10-year risk of first atherosclerotic cardiovascular diseases events among American adults: National Health and Nutrition Examination Survey
CONCLUSION: Higher VAI or LAP scores are significantly associated with elevated 10-year ASCVD risk in adults aged 40 to 79 in the USA, which suggested that monitoring visceral obesity is crucial to reduce the risk of a first ASCVD event.PMID:37674809 | PMC:PMC10479018 | DOI:10.3389/fcvm.2023.1249401
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Liying Zheng Aochuan Sun Senfu Han Rongming Qi Rumeng Wang Xiao Gong Mei Xue Source Type: research
Obesity, Weight Gain, and Fluid Overload in Peritoneal Dialysis
Front Nephrol. 2022 Jun 28;2:880097. doi: 10.3389/fneph.2022.880097. eCollection 2022.ABSTRACTObesity is a global epidemic that has a complicated pathogenesis as well as impact on the outcome of peritoneal dialysis (PD) patients. In this review, the prevalence of obesity in incident PD patients as well as the phenomenon of new-onset glucose intolerance after PD will be reviewed. Published literature on the effect of obesity on the survival and incidence of cardiovascular disease in PD patients will be discussed. Particular emphasis would be put on literature that compared the impact of obesity on the outcome of hemodialysi...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Jack Kit-Chung Ng Win Hlaing Than Cheuk Chun Szeto Source Type: research
Association between visceral obesity and 10-year risk of first atherosclerotic cardiovascular diseases events among American adults: National Health and Nutrition Examination Survey
CONCLUSION: Higher VAI or LAP scores are significantly associated with elevated 10-year ASCVD risk in adults aged 40 to 79 in the USA, which suggested that monitoring visceral obesity is crucial to reduce the risk of a first ASCVD event.PMID:37674809 | PMC:PMC10479018 | DOI:10.3389/fcvm.2023.1249401
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Liying Zheng Aochuan Sun Senfu Han Rongming Qi Rumeng Wang Xiao Gong Mei Xue Source Type: research
Masoprocol: a promising candidate for targeting insulin resistance by inhibiting resistin with optimal druglikeness Potentials: an < em > in silico < /em > approach
This study was conducted to screen the clinically approved drugs to find the most potent one to inhibit resistin with the best pharmacokinetics and drug-likeness properties. A total of 4654 clinically approved drugs were docked against the Cys22 residue of resistin. The top ten drugs with the highest high-precision (XP) docking scores were selected. Ioversol and masoprocol showed the highest XP docking and Molecular Mechanics-Generalized Born Surface Area (MMGBSA) scores, respectively, with double hydrogen bonding with the targeted Cys22. Molecular dynamics (MD) simulations showed that the masoprocol-resistin complex exhib...
Source: Atherosclerosis - September 6, 2023 Category: Cardiology Authors: Mohammed Baqur S Al-Shuhaib Sarfaraz Alam Salman Ali Khan Hayder O Hashim Daniel H Obayes Jafar M B Al-Shuhaib Source Type: research
Prevalence of hs-CRP among Indians with hypertension
Bioinformation. 2022 Oct 31;18(10):1041-1043. doi: 10.6026/973206300181041. eCollection 2022.ABSTRACTThe prevalence of hypertension in the early twentieth century varied in India, ranging from 2-15% in Urban India and 2-8% in Rural India. In the inter heart and inter stroke study, hypertension accounted for 17.9% and 34.6% of population attributable risk for coronary artery disease and stroke respectively. CRP appears in serum in response to a variety of inflammatory stimuli .Raised level of hs-CRP is seen with increasing with age, during an infection, inflammation, coronary artery diseases, obesity, sepsis, smoking and va...
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Vasanthii R Kaarthikeyan G Sasirekha G Mahalakshmi S Source Type: research
