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Source: Acta Biochimica et Biophysica Sinica
Condition: Obesity
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Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation.
Abstract
Studies have shown that endothelial insulin resistance induced by oxidative stress contributes to vascular dysfunction in metabolic disorders. Quercetin, a natural antioxidant, has been recently shown to exert protective effects on endothelial function. However, the effects of quercetin on endothelial insulin resistance and its underlying mechanism are unclear. Here, we found that chronic oral treatment of obese mice with quercetin increased vascular endothelial insulin sensitivity, accompanied by alleviated mitochondrial fragmentation as revealed by confocal imaging. In addition, western blot analysis sh...
Source: Acta Biochimica et Biophysica Sinica - November 27, 2019 Category: Biochemistry Authors: Chen C, Huang J, Shen J, Bai Q Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research
