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Clinical Picture Ischaemic scalp ulceration and hair loss
A 46-year-old woman presented to our outpatient clinic in June, 2013, with frequent collapse, ischaemic scalp ulcerations, and hair loss (). She had undergone carotid endarterectomy in 2005, after a small right hemispheric stroke, and had no other medical history apart from hypercholesterolaemia. She had no previous dermatological or scalp problems. She took clopidogrel 75 mg, aspirin 80 mg, and simvastatin 40 mg daily.
Source: LANCET - October 11, 2014 Category: Journals (General) Authors: Çağdaş Ünlü, Jean-Paul P M de Vries Tags: Clinical Picture Source Type: research

Correspondence Metabolic mediators of body-mass index and cardiovascular risk
The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration reported that nearly half of the excess risk of body-mass index (BMI) on coronary heart disease and three-quarters of that on stroke is mediated through blood pressure, cholesterol, and markers of glycaemia. Although these findings correctly support the idea that the adverse effects of high BMI can be substantially mitigated by targeting its metabolic mediators, the report's results underestimate by about 25% the extent to which these metabolic factors mediate the effects of BMI on cardiovascular risk.
Source: LANCET - June 13, 2014 Category: Journals (General) Authors: David Wormser, Angela M Wood, Emanuele Di Angelantonio, Simon G Thompson, John Danesh, for the Emerging Risk Factors Collaboration Tags: Correspondence Source Type: research

Articles Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants
Interventions that reduce high blood pressure, cholesterol, and glucose might address about half of excess risk of coronary heart disease and three-quarters of excess risk of stroke associated with high BMI. Maintenance of optimum bodyweight is needed for the full benefits.
Source: LANCET - March 14, 2014 Category: Journals (General) Authors: The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects) Tags: Articles Source Type: research

Editorial Statins for millions more?
Last week, the National Institute for Health and Care Excellence (NICE) in the UK unveiled draft guidance on cardiovascular risk assessment and, in particular, on lipid modification for the primary and secondary prevention of cardiovascular disease. In an update to the existing guideline, the new proposal is that the threshold be halved for prescribing statins to prevent cardiovascular disease, which includes coronary heart disease and stroke.
Source: LANCET - February 21, 2014 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

Comment Statins: new American guidelines for prevention of cardiovascular disease
Guidelines released on Nov 13, 2013, by the American Heart Association (AHA) and the American College of Cardiology (ACC) for the management of cholesterol are a major step in the right direction. These new guidelines emphasise prevention of stroke as well as heart disease, focus appropriately on statin therapy rather than alternative unproven therapeutic agents, and recognise that more intensive treatment is superior to less intensive treatment for many patients. Furthermore, the new ACC/AHA guidelines show that for individuals in whom statin therapy is clearly indicated (such as those with previous vascular disease or LD...
Source: LANCET - November 30, 2013 Category: Journals (General) Authors: Paul M Ridker, Nancy R Cook Tags: Comment Source Type: research

Editorial Statins: new US guideline sparks controversy
Statins reduce cholesterol and are prescribed to many millions of people in high-income countries—not only high-risk patients with familial hypercholesterolaemia, for example, but also for primary prevention of atherosclerotic cardiovascular disease. Adverse events such as statin-induced myopathy are rare, and statins are likely to have contributed to the substantial fall in cardiovascular events, including stroke, at population level in recent decades.
Source: LANCET - November 23, 2013 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research