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Carotid dysfunction in senescent female mice is mediated by increased α < sub > 1A < /sub > -adrenoceptor activity and COX-derived vasoconstrictor prostanoids
In conclusion, senescence intensifies vasoconstriction mediated by a1A-adrenergic signaling in the carotid of female mice by mechanisms involving increased iCa+2 and release of cyclooxygenase-derived prostanoids.PMID:36705993 | DOI:10.1152/ajpheart.00495.2022
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 27, 2023 Category: Physiology Authors: Tiago J Costa Paula R Barros Diego A Duarte J úlio A Silva-Neto Sara Cristina Hott Thamyris Santos-Silva Claudio M Costa-Neto Felipe V Gomes Eliana H Akamine Cameron G McCarthy Francesc Jim énez-Altayó Ana Paula Dantas Rita C Tostes Source Type: research

Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload induced heart failure.
This study tests if ICG cholinergic neuron activation mitigates the progression of cardiac dysfunction and reduces mortality that occurs in HF. HF was induced by transaortic constriction (TAC) in male transgenic Long Evans rats expressing Cre recombinase within choline acetyltransferase (ChAT) neurons. ChAT neurons were selectively activated by expression and activation of excitatory Designer Receptors Exclusively Activated by Designer Receptors (DREADDs) by Clozapine-N-Oxide (TAC +Treatment & Sham Treated groups). Control animals expressed DREADDs but received saline (Sham and TAC groups). A separate set of animals we...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2020 Category: Physiology Authors: Dyavanapalli J, Hora AJ, Escobar JB, Schloen JR, Dwyer MKR, Rodriguez J, Spurney CF, Kay MW, Mendelowitz D Tags: Am J Physiol Heart Circ Physiol Source Type: research