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Assessment of the Relationship Between Serum Vascular Adhesion Protein-1 (VAP-1) and Severity of Calcific Aortic Valve Stenosis.
CONCLUSIONS: The present study was the first to demonstrate a significant relationship between increased serum VAP-1 levels and the severity of calcific AS. VAP-1 might be a useful biomarker for the evaluation of AS and the follow up of its severity. PMID: 27997774 [PubMed]
Source: Journal of Heart Valve Disease - December 22, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Aortic Valve Replacement in Redo-Scenarios: A Comparison Between Traditional Aortic Valve Replacement (TAVR) and Transapical-TAVR from Two Real-World Multicenter Registries.
CONCLUSIONS: Outcome differences between RAVR and TaTAVR in redo-scenarios reflect methodological differences and different baseline risk profiles. Propensity-matched patients showed a better renal outcome after TaTAVR. *Drs. Onorati and D'Onofrio contributed equally to this article and should both be considered as first authors. PMID: 27997769 [PubMed]
Source: Journal of Heart Valve Disease - December 22, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Intravenous Recombinant Tissue Plasminogen Activator Therapy for Acute Basilar Artery Ischemic Stroke Following Transfemoral Transcatheter Aortic Valve Implantation.
Authors: Montarello NJ, Nelson AJ, Sidharta SL, Worthley SG Abstract Transcatheter aortic valve implantation (TAVI) can now be considered a standard of care for inoperable and high-risk surgical patients with severe aortic stenosis, and its uptake worldwide is rapidly increasing. Indeed, many centers performing the procedure have now moved towards treating intermediate-risk patients with TAVI rather than referring them for surgical aortic valve replacement. Although the incidence of peri-procedural acute and subacute stroke following TAVI has fallen to 2-5%, its occurrence can be life-threatening and life-changing,...
Source: Journal of Heart Valve Disease - December 21, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Acute Invasive Hemodynamic Effects of Transcatheter Aortic Valve Replacement.
CONCLUSIONS: Successful TAVR results in immediate and sizeable improvements in SV and CI, reductions in left and right ventricular filling pressures, and marked reductions in systemic and pulmonary vascular resistances. PMID: 27989060 [PubMed - in process]
Source: Journal of Heart Valve Disease - December 21, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Anticoagulation After Biological Aortic Valve Replacement: Is There An Optimal Regimen?
CONCLUSIONS: Plasma anticoagulation with warfarin during the early postoperative phase was shown statistically to be inferior to platelet aggregation inhibition by aspirin with regards to postoperative bleeding risk, cerebral ischemic events, and survival. PMID: 27989055 [PubMed - in process]
Source: Journal of Heart Valve Disease - December 21, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Quantitative Doppler for Estimation of Paravalvular Leakage after Transcatheter Aortic Valve Implantation.
CONCLUSIONS: The relationship between calculated PVL volume in TAVI patients and other estimates of PVL severity was poor, most likely due to intrinsic errors made in the quantitative Doppler method. Therefore, one should be prudent to include the quantitative Doppler method in TAVI patients in clinical trials and clinical decision-making, in particular in patients with reduced image quality. PMID: 27989038 [PubMed - in process]
Source: Journal of Heart Valve Disease - December 21, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Transcatheter Aortic Valve Implantation in Patients at Extremely High Risk of Perioperative Mortality.
CONCLUSION: The data acquired verified that TAVI is a safe procedure, even in patients with an extremely high predicted risk of perioperative mortality and major adverse cardiac and cerebrovascular events. Furthermore, the analysis substantiated the need for individualized risk evaluation. PMID: 26897844 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

A Comprehensive Fluid Dynamic and Geometric Study for an "In-Vitro" Comparison of Four Surgically Implanted Pericardial Stented Valves.
CONCLUSION: The study results combined the fluid dynamic reproducibility of the in-vitro setting and the specificity of surgery. A quantitative comparison of the fluid dynamic performance of the different bioprostheses was feasible. PMID: 26897839 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

A Matched-Paired Comparative Analysis Ot tne Hemodynamics of the Trifecta and Perimount Aortic Bioprostheses.
CONCLUSION: Trifecta valve implantation is associated with a significant improvement in EOA and a decreased incidence of PPM as compared to the Perimount valve. The superior hemodynamic outcomes observed support consideration of this valve for aortic valve replacement, particularly in patients with a small LVOT at risk for PPM. PMID: 26897822 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Early and Late Outcomes After Minimally Invasive Mitral Valve Repair Surgery.
CONCLUSION: These data are the first from the U.K. demonstrating early and late outcomes after thoracoscopic assisted minimally invasive mitral valve repair surgery. The data establish the safety and efficacy of the technique and, importantly, lend further support towards a prospective randomized comparison of minimally invasive versus conventional mitral valve repair surgery. PMID: 26897819 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Myocardial and Cardiocirculatory Reserve in Asymptomatic Aortic Stenosis and Preserved Ejection Fraction.
CONCLUSION: Besides SWL and female gender, the EF after dobutamine as well as highest exercise stress intensity reached are helpful in determining the prognosis of asymptomatic patients with moderate-severe AS. PMID: 26897816 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Valve Replacement for Moderate Aortic Stenosis in Octogenarians Undergoing Revascularization.
CONCLUSION: In-hospital mortality is higher for octogenarians undergoing CABG+AVR compared to those undergoing isolated CABG. In the present study, a 'prophylactic' AVR was justified in patients with moderate AS, and their increased mortality (versus isolated CABG) was congruent with a higher preoperative co-morbid risk profile. Excellent long- term symptom-free survival further justifies 'prophylactic' AVR in octogenarians undergoing CABG with coexistent moderate AS. PMID: 26897807 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Clinical Value of Ankle-Brachial Index in Asymptomatic Aortic Stenosis Patients.
CONCLUSION: Among asymptomatic AS patients, 35.8% had an abnormal ABI and this was related to previous diabetes. These patients walked less in the 6MWT but did not have a worse prognosis at follow up. PMID: 26204678 [PubMed - in process]
Source: Journal of Heart Valve Disease - July 25, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Valvuloplasty with a paclitaxel-eluting balloon prevents restenosis in an experimental animal model of aortic stenosis.
CONCLUSION: Use of a paclitaxel-eluting valvuloplasty balloon in an animal model of AS resulted in attenuated restenosis, secondary to decrease in valve proliferation and calcification. PMID: 25803975 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 26, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

'Paradoxical' low-flow, low-gradient severe aortic valve stenosis: an entity with limited improvement following transcatheter aortic valve implantation.
CONCLUSION: Patients with PLF-LG-AS may represent a subgroup with a worse clinical outcome after TAVI. PMID: 25803970 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 26, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

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