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Electrocardiographic Deep Terminal Negativity of the P Wave in V1 and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities (ARIC) Study Coronary Heart Disease
Conclusion DTNPV1 is predictive of SCD suggesting its potential utility in risk stratification in the general population.
Source: JAHA:Journal of the American Heart Association - November 21, 2014 Category: Cardiology Authors: Tereshchenko, L. G., Henrikson, C. A., Sotoodehnia, N., Arking, D. E., Agarwal, S. K., Siscovick, D. S., Post, W. S., Solomon, S. D., Coresh, J., Josephson, M. E., Soliman, E. Z. Tags: Coronary Heart Disease Source Type: research

Meta-Analysis of Intracranial Hemorrhage in Acute Coronary Syndromes: Incidence, Predictors, and Clinical Outcomes Coronary Heart Disease
Conclusions In patients with NSTE ACS enrolled in recent clinical trials of antithrombotic therapies, ICH was uncommon. Patients with older age, prior transient ischemic attack/stroke, higher systolic blood pressure, or larger number of antithrombotic agents were at increased risk. One-third of patients with ICH died. These data may be useful to trialists and data and safety monitoring committees for trial conduct and monitoring. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifiers: TRACER: NCT00527943, PLATO: NCT00391872, APPRAISE-2: NCT00831441, TRILOGY ACS: NCT00699998.
Source: JAHA:Journal of the American Heart Association - June 18, 2015 Category: Cardiology Authors: Mahaffey, K. W., Hager, R., Wojdyla, D., White, H. D., Armstrong, P. W., Alexander, J. H., Tricoci, P., Lopes, R. D., Ohman, E. M., Roe, M. T., Harrington, R. A., Wallentin, L. Tags: Coronary Heart Disease Source Type: research

Asymmetric Dimethylarginine and Cardiovascular Risk: Systematic Review and Meta-Analysis of 22 Prospective Studies Epidemiology
Conclusions Available prospective studies suggest associations between circulating ADMA concentration and CVD outcomes under a broad range of circumstances. Further research is needed to better clarify these associations, particularly in large general population studies.
Source: JAHA:Journal of the American Heart Association - May 28, 2015 Category: Cardiology Authors: Willeit, P., Freitag, D. F., Laukkanen, J. A., Chowdhury, S., Gobin, R., Mayr, M., Di Angelantonio, E., Chowdhury, R. Tags: Epidemiology Source Type: research

Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF-TIMI48 Trial Arrhythmia and Electrophysiology
Conclusions Patients with AF who were selected by their physicians to receive SAPT in addition to an anticoagulant had a similar risk of stroke/SEE and higher rates of bleeding than those not receiving SAPT. Edoxaban exhibited similar relative efficacy and reduced bleeding compared to warfarin, with or without concomitant SAPT. Clinical Trial Registration URL: http://www.clinicaltrials.gov/. Unique identifier: NCT00781391.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Xu, H., Ruff, C. T., Giugliano, R. P., Murphy, S. A., Nordio, F., Patel, I., Shi, M., Mercuri, M., Antman, E. M., Braunwald, E. Tags: Platelets, Chronic Ischemic Heart Disease, Anticoagulants, Acute Coronary Syndromes Arrhythmia and Electrophysiology Source Type: research

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials Epidemiology
BackgroundResults from observational and genetic epidemiological studies suggest that lower serum homocysteine levels are associated with lower incidence of cardiovascular disease (CVD). Numerous randomized controlled trials have investigated the efficacy of lowering homocysteine with folic acid supplementation for CVD risk, but conflicting results have been reported.Methods and ResultsThree bibliographic databases (Medline, Embase, and the Cochrane Database of Systematic Reviews) were searched from database inception until December 1, 2015. Of the 1933 references reviewed for eligibility, 30 randomized controlled trials i...
Source: JAHA:Journal of the American Heart Association - August 14, 2016 Category: Cardiology Authors: Li, Y., Huang, T., Zheng, Y., Muka, T., Troup, J., Hu, F. B. Tags: Cardiovascular Disease, Diet and Nutrition Original Research Source Type: research

Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
BackgroundCoronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown.Methods and ResultsCVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound‐detected plaques in the common, bifurcation, and internal carotid artery segments. CAC was detected by computed tomography. Predictive ...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Gepner, A. D., Young, R., Delaney, J. A., Budoff, M. J., Polak, J. F., Blaha, M. J., Post, W. S., Michos, E. D., Kaufman, J., Stein, J. H. Tags: Epidemiology, Primary Prevention, Risk Factors, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research

Dynamic TIMI Risk Score for STEMI Coronary Heart Disease
Conclusions This score is a prospectively derived, validated means of estimating 1-year mortality of STEMI at hospital discharge and can serve as a clinically useful tool. By incorporating events during the index hospitalization, it can better define risk and help to guide treatment decisions.
Source: JAHA:Journal of the American Heart Association - January 29, 2013 Category: Cardiology Authors: Amin, S. T., Morrow, D. A., Braunwald, E., Sloan, S., Contant, C., Murphy, S., Antman, E. M. Tags: Coronary Heart Disease Source Type: research

Associations of Plasma Phospholipid and Dietary Alpha Linolenic Acid With Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study Arrhythmia and Electrophysiology
Conclusions Results from this prospective cohort study of older adults indicate no association of plasma phospholipid or dietary ALA and incident AF.
Source: JAHA:Journal of the American Heart Association - January 31, 2013 Category: Cardiology Authors: Fretts, A. M., Mozaffarian, D., Siscovick, D. S., Heckbert, S. R., McKnight, B., King, I. B., Rimm, E. B., Psaty, B. M., Sacks, F. M., Song, X., Spiegelman, D., Lemaitre, R. N. Tags: Arrhythmia and Electrophysiology Source Type: research

Sex-Specific Differences in the Predictive Value of Cholesterol Homeostasis Markers and 10-Year Cardiovascular Disease Event Rate in Framingham Offspring Study Participants Coronary Heart Disease
Conclusions These data suggest significant sex differences in the 10-year prognostic value of cholesterol synthesis markers and HCHD, specifically coronary death and incidence of myocardial infarction. Clinical Trial Registration URL:http://ClinicalTrials.gov. Unique identifier: NCT00074464.
Source: JAHA:Journal of the American Heart Association - February 19, 2013 Category: Cardiology Authors: Matthan, N. R., Zhu, L., Pencina, M., D'Agostino, R. B., Schaefer, E. J., Lichtenstein, A. H. Tags: Coronary Heart Disease Source Type: research

The Value of Carotid Artery Plaque and Intima-Media Thickness for Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis Epidemiology
Conclusion Ultrasound-derived plaque metrics independently predict cardiovascular events in our cohort and improve risk prediction for CHD events when added to Framingham risk factors.
Source: JAHA:Journal of the American Heart Association - April 8, 2013 Category: Cardiology Authors: Polak, J. F., Szklo, M., Kronmal, R. A., Burke, G. L., Shea, S., Zavodni, A. E. H., O'Leary, D. H. Tags: Epidemiology Source Type: research

Hostility, Health Behaviors, and Risk of Recurrent Events in Patients With Stable Coronary Heart Disease: Findings From the Heart and Soul Study Epidemiology
Conclusions Hostility was a significant predictor of secondary events in this sample of outpatients with baseline stable CHD. Much of this association was moderated by poor health behaviors, specifically physical inactivity and smoking.
Source: JAHA:Journal of the American Heart Association - September 30, 2013 Category: Cardiology Authors: Wong, J. M., Na, B., Regan, M. C., Whooley, M. A. Tags: Epidemiology Source Type: research

Circulating and Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Incidence of CVD in the Multi-Ethnic Study of Atherosclerosis Epidemiology
Conclusions Both dietary and circulating eicosapentaenoic acid and docosahexaenoic acid, but not alpha-linolenic acid or n-6 PUFA, were inversely associated with CVD incidence. These findings suggest that increased consumption of n-3 PUFA from seafood may prevent CVD development in a multiethnic population.
Source: JAHA:Journal of the American Heart Association - December 18, 2013 Category: Cardiology Authors: de Oliveira Otto, M. C., Wu, J. H. Y., Baylin, A., Vaidya, D., Rich, S. S., Tsai, M. Y., Jacobs, D. R., Mozaffarian, D. Tags: Epidemiology Source Type: research

Long-term Cardiovascular Outcomes in Patients With Chronic Kidney Disease Undergoing Coronary Artery Bypass Graft Surgery for Acute Coronary Syndromes Cardiovascular Surgery
Conclusions Severe, but not moderate, renal dysfunction was independently associated with an increased risk of long-term cardiovascular events and death in patients undergoing CABG for acute coronary syndromes.
Source: JAHA:Journal of the American Heart Association - March 4, 2014 Category: Cardiology Authors: Holzmann, M., Jernberg, T., Szummer, K., Sartipy, U. Tags: Cardiovascular Surgery Source Type: research

Early Clopidogrel Versus Prasugrel Use Among Contemporary STEMI and NSTEMI Patients in the US: Insights From the National Cardiovascular Data Registry Coronary Heart Disease
Conclusions With prasugrel as an antiplatelet treatment option, contemporary practice shows low uptake of prasugrel and delays in P2Y12 antagonist initiation among NSTEMI patients. We also note concerning evidence of inappropriate use of prasugrel, and inadequate targeting of this more potent therapy to maximize the benefit/risk ratio.
Source: JAHA:Journal of the American Heart Association - April 14, 2014 Category: Cardiology Authors: Sherwood, M. W., Wiviott, S. D., Peng, S. A., Roe, M. T., DeLemos, J., Peterson, E. D., Wang, T. Y. Tags: Coronary Heart Disease Source Type: research

Long-term Cardiovascular Risks Associated With an Elevated Heart Rate: The Framingham Heart Study Epidemiology
Conclusions Individuals with a higher heart rate are at elevated long-term risk for cardiovascular events, in particular, heart failure, and all-cause death. On the other hand, a higher heart rate is associated with a lower risk of future permanent pacemaker implantation.
Source: JAHA:Journal of the American Heart Association - May 8, 2014 Category: Cardiology Authors: Ho, J. E., Larson, M. G., Ghorbani, A., Cheng, S., Coglianese, E. E., Vasan, R. S., Wang, T. J. Tags: Epidemiology Source Type: research

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