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Association of Proton Pump Inhibitors With Higher Risk of Cardiovascular Disease and Heart Failure
To examine associations of cumulative exposure to proton pump inhibitors (PPIs) with total cardiovascular disease (CVD; composed of stroke, coronary heart disease, and heart failure [HF]) and HF alone in a cohort study of White and African American participants of the Atherosclerosis Risk in Communities (ARIC) study.
Source: Mayo Clinic Proceedings - October 1, 2021 Category: Internal Medicine Authors: Elizabeth J. Bell, Suzette J. Bielinski, Jennifer L. St. Sauver, Lin Y. Chen, Mary R. Rooney, Nicholas B. Larson, Paul Y. Takahashi, Aaron R. Folsom Tags: Original article Source Type: research

Premature Atrial Contractions
Premature atrial contractions (PACs) can be seen in a broad spectrum of patients with and without heart disease and are often considered benign clinical phenomena. Recent studies have, however, shown an association between PACs and new-onset atrial fibrillation (AF), stroke, and all-cause mortality.1,2 Simultaneously, reporting of the association between cardiac arrhythmias such as AF, atrial structural disease, and cerebrovascular diseases such as stroke and dementia have expanded our understanding of the complex web of interaction between the heart and brain.
Source: Mayo Clinic Proceedings - May 1, 2021 Category: Internal Medicine Authors: Chaitra Janga, Malini Madhavan Tags: Editorial Source Type: research

Geographic Inequalities in Cardiovascular Mortality in the United States: 1999 to 2018
To evaluate the trends in cardiovascular, ischemic heart disease (IHD), stroke, and heart failure mortality in the stroke belt in comparison with the rest of the United States.
Source: Mayo Clinic Proceedings - April 8, 2021 Category: Internal Medicine Authors: Vibhu Parcha, Rajat Kalra, Ana F. Best, Nirav Patel, Sarabjeet S. Suri, Thomas J. Wang, Garima Arora, Pankaj Arora Tags: Original article Source Type: research

Legacy of Nutritionist Ancel Keys
A diet high in saturated fat increases risk for heart disease and stroke. We know this, but few can recall who first uncovered the connection. It was Ancel Keys — a name to note and remember. Some 60 years ago, he was a luminary in medical science with a reputation that reached ordinary Americans. In 1961, his image graced the cover of TIME magazine. He was the first to promote the health benefits of the Mediterranean diet. An esteemed professor at the Un iversity of Minnesota, Ancel Keys was brilliant, bold, and worldly.
Source: Mayo Clinic Proceedings - February 29, 2020 Category: Internal Medicine Authors: Phillip B. Sparling Tags: Letter to the editor Source Type: research

Cardiovascular Disease in Type 2 Diabetes: A Review of Sex-Related Differences in Predisposition and Prevention
Type 2 diabetes mellitus is a major risk factor for cardiovascular disease. However, compiled data suggest that type 2 diabetes affects the risk of cardiovascular disease differentially according to sex. In recent years, large meta-analyses have confirmed that women with type 2 diabetes have a higher relative risk of incident coronary heart disease, fatal coronary heart disease, and stroke compared with their male counterparts. The reasons for these disparities are not completely elucidated. A greater burden of cardiometabolic risk in women was proposed as a partial explanation.
Source: Mayo Clinic Proceedings - January 31, 2019 Category: Internal Medicine Authors: Abdallah Al-Salameh, Philippe Chanson, Sophie Bucher, Virginie Ringa, Laurent Becquemont Tags: Review Source Type: research

The Pooled Cohort Equations for Predicting Risk of Myocardial Infarction and Stroke: Validated in Representative Natural History Populations
The American College of Cardiology (ACC)/American Heart Association (AHA) Pooled Cohort equations (PCEs) were introduced in late 2013 and published in mid-2014.1 Unlike the Framingham score used to determine coronary heart disease (CHD) risk in the National Cholesterol Education Program Adult Treatment Panel III guidelines,2 the new PCEs focused on estimating risk of CHD and stroke and additionally provided specific risk assessment for African American individuals. Because stroke may occur before CHD, particularly in women and African Americans, the PCEs were seen as a major advance in disease prognostication.
Source: Mayo Clinic Proceedings - May 10, 2016 Category: Internal Medicine Authors: Neil J. Stone, Donald M. Lloyd-Jones Tags: Editorial Source Type: research