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Meta-Analysis Addressing the Effect of Mineralcorticoid Receptor Antagonists on the Risk for New-Onset Atrial Fibrillation
Atrial fibrillation (AF) constitutes the most common, major cardiac arrhythmia worldwide, with an estimated prevalence in the United States equal to 2.3 million affected subjects, projected to increase to 5.6 million by 2050.1 Hypertension and background heart disease (mainly, congestive heart failure) or valve disease represent main risk factors for AF development.1 Other modifiable risk factors are sedentary lifestyle, smoking, obesity, diabetes mellitus, and obstructive sleep apnea.2 AF is associated with a significant increase in the risk for all-cause and cardiovascular death, ischemic stroke, heart failure (HF), isch...
Source: The American Journal of Cardiology - August 13, 2021 Category: Cardiology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Maria Toumpourleka, Michael Doumas Source Type: research

Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (From the REasons for Geographic and Racial Differences in Stroke Study)
Cardiovascular disease is a leading cause of death. Proneurotensin is a biomarker associated with the development of cardiovascular disease, cardiovascular mortality, and all-cause mortality. We assessed the association of fasting proneurotensin with mortal events by sex and race (black-white) in a United States (US) population. Using a case-cohort sub-population of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, fasting proneurotensin was measured on a 1046-person subcohort and 651 participants with incident coronary heart disease (CHD).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Nicholas Wettersten, Mary Cushman, Virginia J. Howard, Oliver Hartmann, Gerasimos Filippatos, Neil Beri, Paul Clopton, George Howard, Monika M. Safford, Suzanne E. Judd, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research