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Source: Journal of Allergy and Clinical Immunology
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Total 302 results found since Jan 2013.
Human PLCG2 Haploinsufficiency Results in a Novel NK Cell Immunodeficiency
Dominant-negative and gain-of-function variants in PLCG2 have been previously reported to cause cold urticaria, antibody deficiency, and autoinflammation. PLCG2 haploinsufficiency is a distinct and novel immunodeficiency leading to NK cell dysfunction and is associated with severe and/or recurrent herpesvirus infections.
Source: Journal of Allergy and Clinical Immunology - September 12, 2023 Category: Allergy & Immunology Authors: Joshua B. Alinger, Emily M. Mace, Justin.R. Porter, Annelise Y. Mah-Som, Allyssa L. Daugherty, Stephanie Li, Allison A. Throm, Jeanette T. Pingel, Nermina Saucier, Albert Yao, Ivan K. Chinn, James R. Lupski, Mohammad Ehlayel, Michael Keller, Greg R. Bowma Source Type: research
Genome-wide meta-analysis implicates variation affecting mast cell biology in urticaria
Urticaria is characterized by inappropriate mast cell degranulation that leads to the development of wheals and/or angioedema. Twin and family studies indicate that there is a substantial heritable component to urticaria risk.
Source: Journal of Allergy and Clinical Immunology - September 8, 2023 Category: Allergy & Immunology Authors: Sheila Mary McSweeney, Jake Saklatvala, Rossella Rispoli, Clarisse Ganier, Grzegorz Woszczek, Laurent Thomas, Kristian Hveem, Mari L øset, Nick Dand, Christos Tziotzios, Michael Simpson, John Alexander McGrath Source Type: research
Patient-reported outcome measures for urticaria and angioedema
Source: Journal of Allergy and Clinical Immunology - September 1, 2023 Category: Allergy & Immunology Authors: Pedro C. Avila Source Type: research
Urticaria Exacerbations and Adverse Reactions in Patients with Chronic Urticaria Receiving COVID-19 Vaccination: Results of the UCARE COVAC-CU Study
Source: Journal of Allergy and Clinical Immunology - August 11, 2023 Category: Allergy & Immunology Authors: Emek Kocaturk, Pascale Salameh, Esra Sarac, Carolina E. Vera Ayala, Simon Francis Thomsen, Torsten Zuberbier, Luis Felipe Ensina, Todor A. Popov, Martijn van Doorn, Ana Maria Gim énez-Arnau, Riccardo Asero, Paulo Ricardo Criado, Clive Grattan, Niall Conl Source Type: research
Itch in elderly patients: Origin, diagnostics, management
Pruritus affects persons of all ethnicities during all periods of life. However, in younger people, pruritus is caused mostly by chronic inflammation (eg, atopic dermatitis, urticaria) or a well-defined, often self-limiting skin disorder. In elderly patients (aged ≥60 years) pruritic eruptions occur increasingly on clinically unremarkable skin, thus making them more difficult to diagnose accurately.1,2 Recent scientific discoveries regarding physiologic and molecular changes in the skin of elderly patients that occur during the aging process have presented the first clues as to why pruritic dermatoses occur more commonly...
Source: Journal of Allergy and Clinical Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Martin Steinhoff, Sara Al-Khawaga, Joerg Buddenkotte Tags: Paradigms and perspectives Source Type: research
The 7-day recall period version of the Urticaria Control Test – UCT7
The UCT7 is the validated 7-day recall period version of the Urticaria Control Test (UCT), which assesses disease control at short intervals in chronic urticaria patients. Its cutoff value for well-controlled disease is 12 points.
Source: Journal of Allergy and Clinical Immunology - May 17, 2023 Category: Allergy & Immunology Authors: Thomas Buttgereit, Pascale Salameh, Olga Sydorenko, Torsten Zuberbier, Martin Metz, Karsten Weller, Marcus Maurer Source Type: research
The 7-day recall period version of the Urticaria Control Test —UCT7
The Urticaria Control Test (UCT) is a well-established, very easy to use and calculate 4-item patient-reported outcome measure to assess chronic urticaria disease control during the previous 4 weeks. Clinical trials and practice may benefit from the use of a UCT version with a shorter recall period, but this does not exist.
Source: Journal of Allergy and Clinical Immunology - May 17, 2023 Category: Allergy & Immunology Authors: Thomas Buttgereit, Pascale Salameh, Olga Sydorenko, Torsten Zuberbier, Martin Metz, Karsten Weller, Marcus Maurer Source Type: research
A powerful tool with a narrow focus: Aiming genome-wide association studies at chronic spontaneous urticaria
Chronic spontaneous urticaria (CSU) is characterized by itchy wheals and/or angioedema that persist or appear intermittently for at least 6 weeks and can greatly affect quality of life.1,2 CSU is increasingly recognized as an immune-mediated chronic inflammatory disorder.3 A high percentage of patients have symptoms resistant to treatment, requiring a step-up/step-down approach to balance clinical response with treatment risk.1,2,4 The prevalence of CSU is estimated at 0.5% to 1% in the United States and European counties and up to 4% to 5% in Asian and South American countries (data from Africa and other regions are lac...
Source: Journal of Allergy and Clinical Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Lara J. Akinbami, Jonathan A. Bernstein Tags: Editorial Source Type: research
A powerful tool with a narrow focus: aiming genome wide association studies at chronic spontaneous urticaria
Source: Journal of Allergy and Clinical Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Lara J. Akinbami, Jonathan A. Bernstein Source Type: research
Corrigendum
With regard to the article in the December 2022 issue entitled “Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization” (J Allergy Clin Immunol 2022;150:1486-97), the accession number for the original sequence data was not included. The GEO accession number is GSE219154 an d the data is available at: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE219154.
Source: Journal of Allergy and Clinical Immunology - March 1, 2023 Category: Allergy & Immunology Tags: Corrigendum Source Type: research
Urticaria After COVID-19 Vaccination and Vaccine Hesitancy
COVID-19 vaccination efforts continue to curb the pandemic, but 1-2% of individuals experience post-vaccination rashes and are less likely to complete all recommended vaccine doses. We sought to quantify the impact of urticaria after COVID-19 vaccination on quality of life and vaccine hesitancy.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kimberly Blumenthal, Allen Judd, Upeka Samarakoon, Esther Freeman Source Type: research
Predictors of response to omalizumab in chronic spontaneous urticaria
To analyze the predictors of response to omalizumab in chronic spontaneous urticaria (CSU).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Zhirong Du, Yuxiang Zhi Source Type: research
Subacute Onset of Chronic Urticaria Post COVID-19 Vaccination
Urticaria has been known to be triggered for a variety of allergy and non-allergic etiologies. Autoimmune disease, infection, and immunizations can be considered as possible underlying differentials for non-allergic urticarial eruption. I hypothesized that a subacute onset of chronic urticarial eruptions and/or demographic state was also possibly attributable to COVID-19 vaccinations in select patients observed at a single allergy and immunology practice.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kristy Semenza Source Type: research
Is There Any Relationship Between Chronic Urticaria, Its Severity and Alexithymia?
Increased attention is being paid to alexithymia in skin diseases, and has been described as a worrisome comorbidity. The goal of the cross-sectional study was to explore the relationship between chronic urticaria (CU) and its severity on alexithymia.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Luis Miguel Escalante Fiallos, Ivan Cherrez Ojeda, Simon Thomsen, Ana Gim énez-Arnau, Jennifer Astrup Sørensen, Kiran Godse, Carole Guillet, Astrid Karolina Maldonado Apolo, Gonzalo Chorzepa, Blanca Morfin-Maciel, Jose Ignacio Larco Sousa, Erika De Arru Source Type: research
Severe work-related asthma from gum arabic exposure in a bubblegum factory worker
Gum arabic, derived from Acacia trees, is a branched polysaccharide used in the food industry. It has been implicated as causing occupational asthma, contact urticaria, and rhinitis. Life-threatening allergic manifestations have not been reported.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Felix Chan, Allison Kwan, Susan Tarlo Source Type: research
