• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

A Phase 2a dose ‐escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS‐986231 in hospitalized patients with heart failure with reduced ejection fraction
ConclusionsBMS‐986231 demonstrated a favourable safety and haemodynamic profile in patients hospitalized with advanced heart failure. Based on preclinical data and these study's findings, it is possible that the haemodynamic benefits may be mediated by inotropic and/or lusitropic as well as vasodilatory effects. The therapeutic potential of BMS‐986231 should be further assessed in patients with heart failure.
Source: European Journal of Heart Failure - June 1, 2017 Category: Cardiology Authors: Cristina Tita, Edward M. Gilbert, Adrian B. Van Bakel, Jacek Grzybowski, Garrie J. Haas, Mohammad Jarrah, Stephanie H. Dunlap, Stephen S. Gottlieb, Marc Klapholz, Parag C. Patel, Roman Pfister, Tim Seidler, Keyur B. Shah, Tomasz Zieli ński, Robert P. Ven Tags: Original Article Source Type: research

Implication of pulmonary hypertension in patients undergoing MitraClip therapy: results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry
ConclusionsDespite higher mortality in patients with elevated sPAP, these data suggest the safety, feasibility and benefit of MitraClip therapy even in advanced stages of disease. An early approach might prevent the progress of pulmonary hypertension and improve outcomes.
Source: European Journal of Heart Failure - July 1, 2017 Category: Cardiology Authors: Eike Tigges, Stefan Blankenberg, R. Stephan von Bardeleben, Christine Z ürn, Raffi Bekeredjian, Taoufik Ouarrak, Horst Sievert, Georg Nickenig, Peter Boekstegers, Jochen Senges, Wolfgang Schillinger, Edith Lubos Tags: Original Article Source Type: research

Inotropic myocardial reserve deficiency is the predominant feature of exercise haemodynamics in cardiac amyloidosis
ConclusionsCardiac amyloid deposits are associated with severely reduced inotropic myocardial reserve and increased left and right ventricular filling pressures during exercise. Furthermore, CA subjects have severely reduced PAC, which may contribute to right heart failure and reduced exercise capacity.
Source: European Journal of Heart Failure - August 24, 2017 Category: Cardiology Authors: Tor Skibsted Clemmensen, Henning M ølgaard, Jens Sörensen, Hans Eiskjaer, Niels Frost Andersen, Søren Mellemkjaer, Mads Jønsson Andersen, Lars Poulsen Tolbod, Hendrik J. Harms, Steen Hvitfeldt Poulsen Tags: Original Article Source Type: research

Long ‐term outcomes for different surgical strategies to treat left ventricular outflow tract obstruction in hypertrophic cardiomyopathy
ConclusionSeptal myectomy is a safe procedure resulting in symptomatic improvement in the majority of patients. The annual incidence of non‐fatal disease‐related complications after surgical treatment of LVOTO is relatively high. Patients who underwent MV replacements had poorer outcomes with less symptomatic benefit in spite of a similar reduction in LVOT gradients.
Source: European Journal of Heart Failure - November 16, 2017 Category: Cardiology Authors: Richard Collis, Oliver Watkinson, Constantinos O'Mahony, Oliver P. Guttmann, Antonis Pantazis, Maria Tome ‐Esteban, Victor Tsang, Venkatachalam Chandrasekaran, Christopher G.A. McGregor, Perry M. Elliott Tags: Research Article Source Type: research

Contribution of cardiac and extra ‐cardiac disease burden to risk of cardiovascular outcomes varies by ejection fraction in heart failure
ConclusionIn North American HF patients enrolled in the CHARM trials, the relative contribution of cardiac and extra‐cardiac disease burden to CV outcomes and death differed depending on LVEF. The high risk of events attributable to non‐cardiac disease burden may help explain why cardiac disease‐modifying medication proven to be efficacious in HFrEF patients has not proven beneficial in HFpEF.
Source: European Journal of Heart Failure - November 1, 2017 Category: Cardiology Authors: Emil Wolsk, Brian Claggett, Lars K øber, Stuart Pocock, Salim Yusuf, Karl Swedberg, John J.V. McMurray, Christopher B. Granger, Marc A. Pfeffer, Scott D. Solomon Tags: Research Article Source Type: research

Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association
Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys‐)functions. Bi‐directional feedback interactions between the heart and the brain are inherent in the pathophysiology of HF: (i) the impaired cardiac function affects cerebral structure and functional capacity, and (ii) neuronal signals impact on the cardiovascular continuum. These interactions contribute to the symptomatic presentation of HF patients and affect many co‐morbidities of HF. Moreover, neuro‐cardiac feedback signals significantly promote aggravation and further progression of HF ...
Source: European Journal of Heart Failure - December 27, 2017 Category: Cardiology Authors: Wolfram Doehner, Dilek Ural, Karl Georg Haeusler, Jelena Čelutkienė, Reinaldo Bestetti, Yuksel Cavusoglu, Marco A. Peña‐Duque, Duska Glavas, Massimo Iacoviello, Ulrich Laufs, Ricardo Marmol Alvear, Amam Mbakwem, Massimo F. Piepoli, Stuart D. Rosen, G Tags: Position Paper Source Type: research

Platelet activation is a preoperative risk factor for the development of thromboembolic complications in patients with continuous ‐flow left ventricular assist device
ConclusionsThrombotic events are associated with altered PAS values. Moreover, baseline elevated PAS values in patients who developed thrombotic events suggest patient‐specific tendency to post‐implant thromboembolic complications. Prospectively, systematic monitoring of PAS might guide the development of refined patient‐tailored antithrombotic strategies and the technological improvement of LVAD design.
Source: European Journal of Heart Failure - December 1, 2017 Category: Cardiology Authors: Filippo Consolo, Giulia Sferrazza, Giulia Motolone, Rachele Contri, Lorenzo Valerio, Rosalba Lembo, Loris Pozzi, Patrizia Della Valle, Michele De Bonis, Alberto Zangrillo, Gianfranco B. Fiore, Alberto Redaelli, Marvin J. Slepian, Federico Pappalardo Tags: Research Article Source Type: research

Association between mean systolic and diastolic blood pressure throughout the follow ‐up and cardiovascular events in acute myocardial infarction patients with systolic dysfunction and/or heart failure: an analysis from the High‐Risk Myocardial Infarction Database Initiative
ConclusionSystolic BP values <125 mmHg were associated with increased cardiovascular death, but these findings likely represent a reverse causality phenomenon.
Source: European Journal of Heart Failure - January 4, 2018 Category: Cardiology Authors: Jo ão Pedro Ferreira, Kevin Duarte, Marc A. Pfeffer, John J.V. McMurray, Bertram Pitt, Kenneth Dickstein, Faiez Zannad, Patrick Rossignol, Tags: Research Article Source Type: research

Recent developments and controversies in transcatheter aortic valve implantation
Interventional cardiology has been revolutionised by transcatheter aortic valve implantation (TAVI), which has become established as the benchmark treatment for severe aortic stenosis in patients at high risk for surgical aortic valve replacement (AVR). Increased procedural familiarity and progression in device technology has enabled improvements to be made in complication rates, which have led to a commensurate expansion in the use of TAVI; it is now a viable alternative to AVR in patients at intermediate surgical risk, and has been used in cohorts such as those with bicuspid aortic valves or pure, severe aortic regurgita...
Source: European Journal of Heart Failure - January 25, 2018 Category: Cardiology Authors: Noman Ali, Peysh A. Patel, Steven J. Lindsay Tags: Review Source Type: research

Clinical correlates and outcome associated with changes in 6 ‐minute walking distance in patients with heart failure: findings from the BIOSTAT‐CHF study
ConclusionsThe 6 ‐minute walk test distance at baseline and a decline in walking distance were both associated with worse prognosis but did not improve the prognostic models. 6MWT distance was not modified by treatment up‐titration and its use for assessing the benefits of pharmacologic treatment up‐titration may be limited.
Source: European Journal of Heart Failure - January 1, 2019 Category: Cardiology Authors: Jo ão Pedro Ferreira, Marco Metra, Stefan D. Anker, Kenneth Dickstein, Chim C. Lang, Leong Ng, Nilesh J. Samani, John G. Cleland, Dirk J. van Veldhuisen, Adriaan A. Voors, Faiez Zannad Tags: Research Article Source Type: research

Phenomapping of patients with heart failure with preserved ejection fraction using machine learning ‐based unsupervised cluster analysis
ConclusionsMachine learning ‐based cluster analysis can identify phenogroups of patients with HFpEF with distinct clinical characteristics and long‐term outcomes.
Source: European Journal of Heart Failure - October 20, 2019 Category: Cardiology Authors: Matthew W. Segar, Kershaw V. Patel, Colby Ayers, Mujeeb Basit, W.H. Wilson Tang, Duwayne Willett, Jarett Berry, Justin L. Grodin, Ambarish Pandey Tags: Research Article Source Type: research

Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial
ConclusionsVICTORIA comprises a broadly generalizable high ‐risk population of three unique clinical strata of worsening chronic HFrEF despite very good HF therapy. VICTORIA will establish the role of vericiguat, a soluble guanylate cyclase stimulator, in HFrEF.
Source: European Journal of Heart Failure - December 8, 2019 Category: Cardiology Authors: Burkert Pieske, Mahesh J. Patel, Cynthia M. Westerhout, Kevin J. Anstrom, Javed Butler, Justin Ezekowitz, Adrian F. Hernandez, Joerg Koglin, Carolyn S.P. Lam, Piotr Ponikowski, Lothar Roessig, Adriaan A. Voors, Christopher M. O'Connor, Paul W Tags: Research Article Source Type: research

Pages: 1  2  3  4  5  6  7  8