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Sleep Duration and Cardiovascular Disease Prevalence – The Debate Continues
We read with interest the study by Krittanawong et al “Sleep Duration and Cardiovascular Health in A Representative Community Population (from NHANES, 2005 to 2016)”.1 The authors studied 32,152 participants who responded to the sleep survey and found short sleep duration (9 hours) was also associated with higher prevalence of stroke, heart failure and coronary artery disease.
Source: The American Journal of Cardiology - May 18, 2020 Category: Cardiology Authors: Saurabh Aggarwal, Gaurav Aggarwal, Rohit Seth Loomba Source Type: research

Comparison of Complications and In-Hospital Mortality in Takotsubo (Apical Ballooning/Stress) Cardiomyopathy versus Acute Myocardial Infarction
There are limited data on the incidence of complications and in-hospital outcomes, among patients with Takotsubo cardiomyopathy (TC), as compared to acute myocardial infarction (AMI). From 2007-2014, a retrospective cohort of TC was compared to AMI using the National Inpatient Sample database. Complications were classified as acute heart failure, ventricular arrhythmic, cardiac arrest, high-grade atrioventricular block, mechanical, vascular/access, pericardial, stroke and acute kidney injury. Temporal trends, clinical characteristics and in-hospital outcomes were compared.
Source: The American Journal of Cardiology - July 12, 2020 Category: Cardiology Authors: Saraschandra Vallabhajosyula, Gregory W Barsness, Joerg Herrmann, Nandan S Anavekar, Rajiv Gulati, Abhiram Prasad Source Type: research

Meta-analysis Assessing the Effect of Sodium-glucose Co-transporter-2 Inhibitors on Left Ventricular Mass in Patients with Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) has evolved as a pandemic of the 21st century, while cardiovascular disease (CVD) affects almost one third of patients and represents the cause of death in more than half cases, with coronary artery disease, heart failure (HF) and stroke being the main contributors.1 Hallmark cardiovascular outcome trials published during the last five years have established a novel class of antidiabetics, namely sodium-glucose co-transporter-2 (SGLT-2) inhibitors as a primary treatment option in patients with HF, atherosclerotic cardiovascular disease (ASCVD) or chronic kidney disease (CKD), along with the ...
Source: The American Journal of Cardiology - August 6, 2020 Category: Cardiology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Alexandra Katsimardou, Maria-Styliani Kalogirou, Michael Doumas Source Type: research

Prognostic Implications of Significant Isolated Tricuspid Regurgitation in Patients With Atrial Fibrillation Without Left-Sided Heart Disease or Pulmonary Hypertension
The prognostic impact of isolated tricuspid regurgitation (TR) in patients with atrial fibrillation (AF) has not been investigated. The purpose of this study was to investigate the prognostic implications of significant isolated TR in AF patients without left-sided heart disease, pulmonary hypertension or primary structural abnormalities of the tricuspid valve.A total of 63 AF patients with moderate and severe TR were matched for age and gender to 116 AF patients without significant TR. Patients were followed for the occurrhttps://doi.org/10.13039/100006520ence of all-cause mortality, hospitalization for heart failure and stroke.
Source: The American Journal of Cardiology - August 27, 2020 Category: Cardiology Authors: Marlieke F Dietz, Laurien Goedemans, N Mai Vo, Edgard A Prihadi, Pieter van der Bijl, Bernard J Gersh, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax Source Type: research

Comparison of Frequency of Atrial Fibrillation in Blacks versus Whites and the Utilization of Race in a Novel Risk Score
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia in the world, with over 30 million people affected as of 2010.1 The number of patients projected to develop AF will double over the next decade.2 AF is independently associated with an increased risk of stroke,3 heart failure (HF),4 and mortality.5 It is not surprising, thus, that AF assumes a sizeable share of health care expenditure and its magnitude is reaching epidemic proportions.6 Blacks despite having a higher prevalence of traditional risk factors for AF, such as HF, hypertension, and diabetes mellitus, have been shown to have a lower incidence of AF.
Source: The American Journal of Cardiology - August 27, 2020 Category: Cardiology Authors: Gurukripa N. Kowlgi, Sampath Gunda, Santosh K. Padala, Jayanthi N. Koneru, Abhishek J. Deshmukh, Kenneth A. Ellenbogen Source Type: research

Relation between Thyroid Function and Mortality in patients with Chronic Heart Failure
Thyroid hormones have genomic and non-genomic effects on the cardiovascular system. They increase stroke volume, heart rate, and reduce systemic vascular resistance. (1) Overt thyroid disease (both hypothyroidism and hyperthyroidism) can cause heart failure. (2) Subclinical thyroid dysfunction is present when serum thyroid-stimulating hormone level (TSH) is outside the reference range, but free thyroxine (fT4), and total or free triiodothyronine level (T3) are normal. (3) In subclinical hyperthyroidism, TSH is low, and in subclinical hypothyroidism, TSH is raised.
Source: The American Journal of Cardiology - October 24, 2020 Category: Cardiology Authors: Nathan A. Samuel, Joseph J. Cuthbert, Oliver I. Brown, Syed Kazmi, John G.F. Cleland, Alan S. Rigby, Andrew L. Clark Source Type: research

Optimization of GRACE Risk Stratification by N-Terminal Pro-B-Type Natriuretic Peptide Combined with D-dimer in Patients with Non-ST-elevation Myocardial Infarction
We aimed to explore the utility of multiple biomarkers with GRACE risk stratification for non-ST-elevation myocardial infarction (NSTEMI). A total of 1357 patients diagnosed with NSTEMI were enrolled in this study at multiple medical centers in Tianjin, China. The outcomes were 1-year all-cause death and major adverse cardiac events (MACE: all-cause death, hospital admission for unstable angina, hospital admission for heart failure, non-fatal recurrent myocardial infarction, and stroke). C-index, NRI and IDI were calculated to verify that the biomarkers improve the predictive accuracy of the GRACE score.
Source: The American Journal of Cardiology - November 3, 2020 Category: Cardiology Authors: Peng-Ju Lu, Xiao-Wen Gong, Yin Liu, Feng-Shi Tian, Wen-Juan Zhang, Ying-Wu Liu, Zhu-Hua Yao, Ji-Xiang Wang, Peng Han, Ya-Nan Yang, Zhuang Cui, Jing Gao Source Type: research

Effect of Adenotonsillectomy on Cardiac function in Children Age 5-13 years with Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is associated with hypertension, stroke, heart failure, coronary artery disease and atrial fibrillation in adults1-5. Currently, there is conflicting evidence regarding the degree of improvement in cardiovascular outcomes among adults who are treated for OSA6, 7. Several studies have shown that continuous positive airway pressure (CPAP) therapy in adults partially reverses left ventricular (LV) and right ventricular (RV) dysfunction6, lowers blood pressure8, decreases pulmonary artery pressure9 and improves endothelial dysfunction10.
Source: The American Journal of Cardiology - November 18, 2020 Category: Cardiology Authors: Keren Armoni Domany, Guixia Huang, Md Monir Hossain, Christine L Schuler, Virend K. Somers, Stephen R. Daniels, Raouf Amin Source Type: research

Impact of Age on Gender Difference in Long-term Outcome of Patients with Acute Myocardial Infarction (From J-MINUET)
This study focused on the association between age and gender difference in long-term outcome. We analyzed data from 3283 consecutive patients who were included in a prospective, nationwide, multicenter registry (J-MINUET) from 2012 to 2014. The primary endpoint was the major adverse cardiovascular event (MACE), which was defined as a composite of death, MI, stroke, heart failure, and revascularization for unstable angina during 3 years.
Source: The American Journal of Cardiology - December 3, 2020 Category: Cardiology Authors: Toshio Kimura, Hirokuni Akahori, Masanori Asakura, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teru Source Type: research

Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients with Coronavirus Disease 2019 (From the Yale COVID-19 Cardiovascular Registry)
Individuals with established cardiovascular disease or a high burden of cardiovascular risk factors may be particularly vulnerable to develop complications from coronavirus disease 2019 (COVID-19). We conducted a prospective cohort study at a tertiary care center to identify risk factors for in-hospital mortality and major adverse cardiovascular events (MACE; a composite of myocardial infarction, stroke, new acute decompensated heart failure, venous thromboembolism, ventricular or atrial arrhythmia, pericardial effusion, or aborted cardiac arrest) among consecutively hospitalized adults with COVID-19, using multivariable b...
Source: The American Journal of Cardiology - February 1, 2021 Category: Cardiology Authors: Manan Pareek, Avinainder Singh, Lina Vadlamani, Maxwell Eder, Justin Pacor, Jakob Park, Zaniar Ghazizadeh, Alex Heard, Ana Sofia Cruz-Solbes, Roozbeh Nikooie, Chad Gier, Zain V. Ahmed, James V. Freeman, Judith Meadows, Kim G.E. Smolderen, Rachel Lampert, Source Type: research

Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients after Percutaneous Mitral Valve Repair
Transcatheter mitral valve repair (TMVR) using the MitraClip system (Abbott Vascular, Abbott Park, Illinois) has emerged as an effective treatment option for surgical high-risk patients with severe functional mitral regurgitation (MR) and chronic heart failure (CHF)1-9. However, several predictors of worse prognosis in patients treated by TMVR have been identified, e.g. high levels of NT-proBNP, New York Heart Association (NYHA) functional class IV prior to TMVR and a severely impaired left and right heart function5,8,10-13.
Source: The American Journal of Cardiology - February 25, 2021 Category: Cardiology Authors: Rico Osteresch, Kathrin Diehl, Patrick Dierks, Johannes Schmucker, Azza Ben Ammar, Andreas Fach, Harald Langer, Ingo Eitel, Rainer Hambrecht, Harm Wienbergen Source Type: research

Prevalence, Incidence and Prognostic Implications of Left Bundle Branch Block in Patients with Chronic Coronary Syndromes (From the CLARIFY Registry)
Left Bundle Branch Block (LBBB) is a frequently encountered electrical abnormality in patients with chronic (more than 3 months after myocardial infarction, or evidence of coronary artery disease with ischemia) coronary syndromes (CCS), but its prognostic significance remains unclear. We aimed to describe the prevalence, incidence and five-year outcomes of LBBB in outpatients with CCS using the CLARIFY registry. Main outcome was a composite of CV death, MI or stroke. Secondary outcomes included all cause death, hospitalization for heart failure (HF) and permanent pacemaker implantation.
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: Arthur Darmon, Gregory Ducrocq, Yedid Elbez, Batric Popovic, Emmanuel Sorbets, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg, CLARIFY Investigators Source Type: research

Effect of Lipoprotein (a) Levels on Long-term Cardiovascular Outcomes in Patients with Myocardial Infarction with Nonobstructive Coronary Arteries
The association between elevated lipoprotein(a) [Lp(a)] and poor outcomes in coronary artery disease (CAD) has been addressed for decades. However, little is known about the prognostic value of Lp(a) in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA). A total of 1179 patients with MINOCA were enrolled and divided into low, medium, and high Lp(a) groups based on the cut-off value of 10 and 30mg/dL. The primary endpoint was major adverse cardiovascular events (MACE), a composite of all-cause death, nonfatal MI, nonfatal stroke, revascularization, and hospitalization for unstable angina or heart failure.
Source: The American Journal of Cardiology - June 12, 2021 Category: Cardiology Authors: Side Gao, Wenjian Ma, Sizhuang Huang, Xuze Lin, Mengyue Yu Source Type: research

Relation of Serum Uric Acid and Cardiovascular Events in Adults Aged 20-49 Years
In this study, we aimed to identify the association of medication na ïve SUA with incident CVD including myocardial infarction (MI), stroke, heart failure (HF) and atrial fibrillation (AF) using a nationwide epidemiological database. We analyzed 353,613 participants aged 20–49 years, who were not taking uric acid lowering medications, and had no prevalent history of cardiovascular disease (CVD) using a nationwide health claims database collected in the JMDC Claims Database between 2005 and 2018.
Source: The American Journal of Cardiology - June 14, 2021 Category: Cardiology Authors: Hikari Seki, Hidehiro Kaneko, Hiroyuki Morita, Hidetaka Itoh, Kojiro Morita, Satoshi Matsuoka, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Yuichiro Yano, Sunao Nakamura, Koichi Node, Hideo Yasunaga, I Tags: Miscellaneous Source Type: research

Relation of Serum Uric Acid and Cardiovascular Events in Young Adults Aged 20-49 Years
In this study, we aimed to identify the association of medication na ïve SUA with incident CVD including myocardial infarction (MI), stroke, heart failure (HF) and atrial fibrillation (AF) using a nationwide epidemiological database. We analyzed 353,613 participants aged 20–49 years, who were not taking UA lowering medications, and had no prevalent history of card iovascular disease (CVD) using a nationwide health claims database collected in the JMDC Claims Database between 2005 and 2018.
Source: The American Journal of Cardiology - June 14, 2021 Category: Cardiology Authors: Hikari Seki, Hidehiro Kaneko, Hiroyuki Morita, Hidetaka Itoh, Kojiro Morita, Satoshi Matsuoka, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Yuichiro Yano, Sunao Nakamura, Koichi Node, Hideo Yasunaga, I Source Type: research

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