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Relation of High Serum Bilirubin to Short-Term Mortality Following a Myocardial Infarction Complicated by Left Ventricular Systolic Dysfunction (From the High-Risk Myocardial Infarction Database Initiative)
We examined the association between serum bilirubin and clinical outcomes in patients with clinical signs of HF and/or left ventricular systolic dysfunction following acute myocardial infarction (MI). 7467 patients from the High-Risk MI Database Initiative with an available baseline total bilirubin concentration were studied. The association between baseline bilirubin concentrations and the composite outcome of cardiovascular mortality, non-fatal stroke, non-fatal MI or hospitalization for HF, cardiovascular mortality and all-cause mortality were assessed using Cox proportional hazards models.
Source: The American Journal of Cardiology - February 5, 2018 Category: Cardiology Authors: Zied Frikha, Jo ão Pedro Ferreira, Erwan Bozec, John J.V. McMurray, Bertram Pitt, Kenneth Dickstein, Patrick Rossignol, Faiez Zannad, Nicolas Girerd, High-risk Myocardial Infarction Database Initiative investigators Source Type: research

Mata-Analysis Comparing Transcatheter Versus Surgical Treatment of Paravalvular Leaks
Percutaneous paravalvular leak (PVL) closure has emerged as a feasible alternative to redo valve surgery. However, comparative data on percutaneous and surgical treatment of PVL are scarce. We performed a systematic review and a meta-analysis of studies on percutaneous and surgical treatment of PVL. Of the 2267 studies screened, 22 eligible studies were analyzed. Primary endpoints were: technical success, 30-day mortality, stroke and length-of-stay. Secondary endpoints were: 1-year mortality, readmission for heart failure, reoperation, and symptomatic improvement at follow-up.
Source: The American Journal of Cardiology - April 19, 2018 Category: Cardiology Authors: Tatiana Busu, Fahad Alqahtani, Vinay Badhwar, Chris C. Cook, Charanjit S. Rihal, Mohamad Alkhouli Source Type: research

Relation of High Serum Bilirubin to Short-Term Mortality Following a Myocardial Infarction Complicated by Left Ventricular Systolic Dysfunction (from the High-Risk Myocardial Infarction Database Initiative)
We examined the association between serum bilirubin and clinical outcomes in patients with clinical signs of HF and/or left ventricular systolic dysfunction after acute myocardial infarction (MI). A total of 7,467 patients from the High-Risk Myocardial Infarction Database Initiative with an available baseline total bilirubin concentration were studied. The association between baseline bilirubin concentrations and the composite outcome of cardiovascular mortality (CVM), nonfatal stroke, nonfatal MI or hospitalization for HF, CVM, and all-cause mortality were assessed using Cox proportional hazards models.
Source: The American Journal of Cardiology - February 5, 2018 Category: Cardiology Authors: Zied Frikha, Jo ão Pedro Ferreira, Erwan Bozec, John J.V. McMurray, Bertram Pitt, Kenneth Dickstein, Patrick Rossignol, Faiez Zannad, Nicolas Girerd, High-Risk Myocardial Infarction Database Initiative Investigators Source Type: research

Meta-analysis Comparing Transcatheter and Surgical Treatments of Paravalvular Leaks
Percutaneous paravalvular leak (PVL) closure has emerged as a feasible alternative to redo valve surgery. However, comparative data on percutaneous and surgical treatment of PVL are scarce. We performed a systematic review and a meta-analysis of studies on percutaneous and surgical treatments of PVL. Of the 2,267 studies screened, 22 eligible studies were analyzed. Primary end points were technical success, 30-day mortality, stroke, and length of stay. Secondary end points were 1-year mortality, readmission for heart failure, reoperation, and symptomatic improvement at follow-up.
Source: The American Journal of Cardiology - April 19, 2018 Category: Cardiology Authors: Tatiana Busu, Fahad Alqahtani, Vinay Badhwar, Chris C. Cook, Charanjit S. Rihal, Mohamad Alkhouli Source Type: research

Meta-analysis Comparing Catheter Guided Ablation Versus Conventional Medical Therapy for Patients with Atrial Fibrillation and Heart Failure with Reduced Ejection Fraction
The prognostic benefit of catheter ablation (CA) for atrial fibrillation (AF) in the setting of heart failure (HF) with reduced ejection fraction (EF) is unclear. A systematic search of medical literature was limited to randomized controlled trials. The primary outcome was all-cause mortality and secondary outcomes were HF hospitalizations, stroke, left ventricular EF improvement, change in 6-minute walk test ( Δ 6MWT) and change in Minnesota living with heart failure questionnaire (Δ MLHFQ). Random effects risk ratios (RR) were calculated for categorical outcomes and standardized mean differences (SMD) for continuous on...
Source: The American Journal of Cardiology - June 4, 2018 Category: Cardiology Authors: Akram Y. Elgendy, Ahmed N. Mahmoud, Muhammad S. Khan, Maryam R. Sheikh, Mohammad K. Mojadidi, Mohamed Omer, Islam Y. Elgendy, Anthony A. Bavry, Kenneth A. Ellenbogen, William M. Miles, Matthew McKillop Source Type: research

Meta-Analysis Comparing Catheter-Guided Ablation Versus Conventional Medical Therapy for Patients With Atrial Fibrillation and Heart Failure With Reduced Ejection Fraction
The prognostic benefit of catheter ablation (CA) for atrial fibrillation in the setting of heart failure (HF) with reduced ejection fraction (EF) is unclear. A systematic search of medical literature was limited to randomized controlled trials. The primary outcome was all-cause mortality, and secondary outcomes were HF hospitalizations, stroke, left ventricular EF improvement, change in 6-minute walk test, and change in Minnesota living with HF questionnaire ( Δ MLHFQ). Random effects risk ratios (RR) were calculated for categorical outcomes and standardized mean differences (SMD) for continuous ones, using Der-Simonian and Liard model.
Source: The American Journal of Cardiology - June 4, 2018 Category: Cardiology Authors: Akram Y. Elgendy, Ahmed N. Mahmoud, Muhammad S. Khan, Maryam R. Sheikh, Mohammad K. Mojadidi, Mohamed Omer, Islam Y. Elgendy, Anthony A. Bavry, Kenneth A. Ellenbogen, William M. Miles, Matthew McKillop Source Type: research

Comparison of In-hospital Outcomes of Patients With-vs-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement
The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy (IC) vs. non-ischemic cardiomyopathy (NIC)) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample (NIS) database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary endpoint was the effect of ICM on in-hospital mortality. Secondary endpoints included peri-procedural vascular complications requiring surgery, post-operative myocardial infarction, stroke and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - November 20, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed Subahi, Oluwole Adegbala, Ahmed S Yassin, Emmanuel Akintoye, Ahmed Abdulrahman, Abdelrahman Ahmed, Adedotun Alade, Mohit Pahuja, Luis Afonso Source Type: research

Comparison of In-Hospital Outcomes of Patients With-Versus-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement
The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy [ICM] versus nonischemic cardiomyopathy) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary end point was the effect of ICM on in-hospital mortality. Secondary end points included periprocedural vascular complications requiring surgery, postoperative myocardial infarction, stroke, and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - November 20, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed Subahi, Oluwole Adegbala, Ahmed S. Yassin, Emmanuel Akintoye, Ahmed Abdulrahman, Abdelrahman Ahmed, Adedotun Alade, Mohit Pahuja, Luis Afonso Source Type: research

Edwards SAPIEN Versus Medtronic Aortic Bioprosthesis In Women Undergoing Transcatheter Aortic Valve Implantation (From the Win-TAVI Registry)
We sought to analyze outcomes of women receiving balloon-expandable valves (BEV) or self-expanding valves (SEV) in contemporary transcatheter aortic valve implantation (TAVI). WIN TAVI (Women's INternational Transcatheter Aortic Valve Implantation) is the first all-female TAVI registry to study the safety and performance of TAVI in women. We compared women treated with BEV (n=408, 46.9%) versus those treated with SEV (n  = 461, 53.1%). The primary efficacy endpoint was the (VARC-2) composite of 1-year all-cause death, stroke, myocardial infarction, hospitalization for valve-related symptoms or heart failure or valve-related dysfunction.
Source: The American Journal of Cardiology - November 7, 2019 Category: Cardiology Authors: Cristina Giannini, Anna Sonia Petronio, Julinda Mehilli, Samantha Sartori, Jaya Chandrasekhar, Michela Faggioni, Thierry Lef èvre, Patrizia Presbitero, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas M. Van Mieghem, Emanu Source Type: research

Comparison of Long-Term Risk Adverse Outcomes In Patients with Atrial Fibrillation Having Ablation vs Antiarrhythmic Medications
The impact of atrial fibrillation (AF) catheter ablation vs. chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients undergoing AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history of diab...
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: James V. Freeman, Grace H. Tabada, Kristi Reynolds, Sue Hee Sung, Daniel E. Singer, Paul J. Wang, Taylor I. Liu, Nigel Gupta, Mark A. Hlatky, Alan S. Go Source Type: research

Comparison of Long-Term Adverse Outcomes in Patients With Atrial Fibrillation Having Ablation Versus Antiarrhythmic Medications
The impact of atrial fibrillation (AF) catheter ablation versus chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1,070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients who underwent AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history ...
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: James V. Freeman, Grace H. Tabada, Kristi Reynolds, Sue Hee Sung, Daniel E. Singer, Paul J. Wang, Taylor I. Liu, Nigel Gupta, Mark A. Hlatky, Alan S. Go Source Type: research

Characteristics and Outcome of Patients ≥75 Years of Age with Prior Coronary Artery Bypass Grafting Admitted for an Acute Coronary Syndrome
The prognostic role of prior coronary artery bypass (CABG) in elderly patients admitted to hospital for an acute coronary syndrome (ACS) is unclear. Therefore, the aim of this study was to compare the prognosis of patients aged ≥75 years admitted for an ACS with or without prior history of CABG. The primary outcome of the study was a composite of overall mortality, recurrent non-fatal myocardial infarction (MI), non-fatal stroke and re-hospitalization for heart failure at 1-year follow-up. We included 2253 ACS patients, aged 81 (78-85) years enrolled in three multicentre studies (the Italian Elderly ACS study, the LADIES...
Source: The American Journal of Cardiology - April 1, 2020 Category: Cardiology Authors: Nuccia Morici, Roberta De Rosa, Gabriele Crimi, Leonardo De Luca, Luca A. Ferri, Laura Lenatti, Luigi Piatti, Giovanni Tortorella, Daniele Grosseto, Nicoletta Franco, Irene Bossi, Claudio Montalto, Roberto Antonicelli, Gianfranco Alicandro, Giuseppe De Lu Source Type: research

Sleep Duration and Cardiovascular Health in A Representative Community Population (from NHANES, 2005 to 2016)
We examined the relation between sleep duration and cardiovascular health among the general population in the United States from 2005 to 2016. We sought to investigate associations between sleep duration and the prevalence of coronary artery disease (CAD), heart failure (HF), stroke, hypertension, diabetes mellitus (DM), and hyperlipidemia.
Source: The American Journal of Cardiology - April 25, 2020 Category: Cardiology Authors: Chayakrit Krittanawong, Anirudh Kumar, Zhen Wang, Hani Jneid, Usman Baber, Roxana Mehran, W. H. Wilson Tang, Deepak L. Bhatt Source Type: research

Sleep Duration and Cardiovascular Disease Prevalence- the Debate Continues
We read with interest the study by Krittanawong et al “Sleep Duration and Cardiovascular Health in A Representative Community Population (from NHANES, 2005 to 2016)”.1 The authors studied 32,152 participants who responded to the sleep survey and found short sleep duration (9 hours) was also associated with higher prevalence of stroke, heart failure and coronary artery disease.
Source: The American Journal of Cardiology - May 18, 2020 Category: Cardiology Authors: Saurabh Aggarwal, Gaurav Aggarwal, Rohit Seth Loomba Source Type: research

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