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Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study
CONCLUSIONS: Available genetic data do not support substantial effects of cardiac traits on the risk of stroke beyond known clinical risk factors. Our findings highlight the need to carefully control for confounding and other potential biases in studies examining candidate cardiac risk factors for stroke.PMID:34911345 | DOI:10.1161/STROKEAHA.121.036306
Source: Atherosclerosis - December 16, 2021 Category: Cardiology Authors: Simon Frerich Rainer Malik Marios K Georgakis Moritz F Sinner Steven J Kittner Braxton D Mitchell Martin Dichgans Source Type: research

Embolic infarct topology differs between atrial fibrillation subtypes and embolic stroke of undetermined source
CONCLUSION: Cortical infarctions were twice as common among patients with AF versus ESUS. Subcortical infarct topography was strongly associated with chronic microvascular ischemic changes and therefore may not represent embolic phenomena. Larger-scale investigations are warranted to discern whether large or multifocal subcortical infarcts ought to be excluded from the ESUS designation.PMID:36130470 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106782
Source: Atherosclerosis - September 21, 2022 Category: Cardiology Authors: Jared Wolfe Solomon Oak Justin Tiongson Nicholas Vigilante Emma Frost Mary Penckofer Lauren Thau Zachary Iezzi Pratit Patel James E Siegler Source Type: research