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Source: Atherosclerosis
Condition: Heart Failure
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Total 212 results found since Jan 2013.
SIRT6 in Vascular Diseases, from Bench to Bedside
Aging Dis. 2022 Jul 11;13(4):1015-1029. doi: 10.14336/AD.2021.1204. eCollection 2022 Jul 11.ABSTRACTAging is a key risk factor for angiogenic dysfunction and cardiovascular diseases, including heart failure, hypertension, atherosclerosis, diabetes, and stroke. Members of the NAD+-dependent class III histone deacetylase family, sirtuins, are conserved regulators of aging and cardiovascular and cerebrovascular diseases. The sirtuin SIRT6 is predominantly located in the nucleus and shows deacetylase activity for acetylated histone 3 lysine 56 and lysine 9 as well as for some non-histone proteins. Over the past decade, experim...
Source: Atherosclerosis - July 20, 2022 Category: Cardiology Authors: Si-Chong Ren Xiangqi Chen Hui Gong Han Wang Chuan Wu Pei-Heng Li Xiao-Feng Chen Jia-Hua Qu Xiaoqiang Tang Source Type: research
Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study
CONCLUSIONS AND RELEVANCE: Our results suggest that joint inhibition of CETP and PCSK9 has additive effects on lipid traits and disease risk, including a lower risk of CAD. Further research may explore whether a combination of CETP- and PCSK9-related therapeutics can benefit high-risk patients who are unable to reach treatment targets with existing options.PMID:35921096 | DOI:10.1001/jamacardio.2022.2333
Source: Atherosclerosis - August 3, 2022 Category: Cardiology Authors: Arjen J Cupido Laurens F Reeskamp Aroon D Hingorani Chris Finan Folkert W Asselbergs G Kees Hovingh Amand F Schmidt Source Type: research
Prediction of cardiovascular outcome by estimated glomerular filtration rate among high-risk patients: a Thai nationwide cohort study
CONCLUSION: Lower baseline kidney function was independently associated with increased risk of CV events and all-cause mortality in Thai populations at high CV risk.PMID:35999302 | DOI:10.1007/s10157-022-02262-5
Source: Atherosclerosis - August 23, 2022 Category: Cardiology Authors: Noppawit Aiumtrakul Annop Kittithaworn Ouppatham Supasyndh Rungroj Krittayaphong Arintaya Phrommintikul Bancha Satirapoj Source Type: research
Physical Function and Subsequent Risk of Cardiovascular Events in Older Adults: The Atherosclerosis Risk in Communities Study
Conclusions Reduced physical function was independently associated with the risk of composite and individual CVD outcomes and improved their risk prediction beyond traditional risk factors in community-dwelling older adults. Although confirmatory studies are needed, our results suggest the potential usefulness of SPPB for classifying CVD risk in older adults.PMID:36043511 | DOI:10.1161/JAHA.121.025780
Source: Atherosclerosis - August 31, 2022 Category: Cardiology Authors: Xiao Hu Yejin Mok Ning Ding Kevin J Sullivan Pamela L Lutsey Jennifer A Schrack Priya Palta Kunihiro Matsushita Source Type: research
Joint exposure to positive affect, life satisfaction, broad depression, and neuroticism and risk of cardiovascular diseases: A prospective cohort study
CONCLUSIONS: Joint exposure to multiple psychological wellbeing factors was associated with increased risks of incident CVD in an additive manner, regardless of genetic susceptibility.PMID:36055801 | DOI:10.1016/j.atherosclerosis.2022.08.007
Source: Atherosclerosis - September 2, 2022 Category: Cardiology Authors: Ying Sun Haojie Zhang Bin Wang Chi Chen Yingchao Chen Yi Chen Fangzhen Xia Xiao Tan Jihui Zhang Qing Li Lu Qi Yingli Lu Ningjian Wang Source Type: research
Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: Atherosclerosis - October 6, 2022 Category: Cardiology Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research
Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study
CONCLUSION: Our MR study suggested that longer telomeres were associated with decreased risk of several CVDs, including coronary atherosclerosis, myocardial infarction, ischemic heart disease, and stroke, as well as an increased risk of hypertension. Future studies are still warranted to validate the results and investigate the mechanisms underlying these associations.PMID:36352846 | PMC:PMC9637552 | DOI:10.3389/fcvm.2022.1012615
Source: Atherosclerosis - November 10, 2022 Category: Cardiology Authors: Yingjian Deng Qiang Li Faguang Zhou Guiyang Li Jianghai Liu Jialan Lv Linlin Li Dong Chang Source Type: research
Glucagon-Like Peptide 1 Receptor Agonists Versus Sodium-Glucose Cotransporter 2 Inhibitors for Atherosclerotic Cardiovascular Disease in Patients With Type 2 Diabetes
Cardiol Res. 2023 Feb;14(1):12-21. doi: 10.14740/cr1459. Epub 2023 Feb 25.ABSTRACTBeyond improving hemoglobin A1c (HbA1c) in adults with type 2 diabetes, glucagon-like peptide 1 receptor agonists (GLP-1RA) have been approved for reducing risk of major adverse cardiovascular events (MACE) with established cardiovascular disease (CVD) or multiple CV risk factors. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) also reduced the risk for the primary composite CV outcome in patients with type 2 diabetes at high risk for CV events. In the American Diabetes Association (ADA) and European Association of Study in Diabetes (EASD)...
Source: Atherosclerosis - March 10, 2023 Category: Cardiology Authors: Hidekatsu Yanai Hiroki Adachi Mariko Hakoshima Hisayuki Katsuyama Source Type: research
The epidemiology, mechanisms, diagnosis and treatment of cardiovascular disease in adult patients with HIV
This article discusses the complex interactions involving HIV infection, the novel and traditional risk factors for CVD, and the antiretroviral HIV therapies which can contribute to CVD in HIV-infected people. In addition, the treatment of HIV+ patients with acute myocardial infarction, stroke, and cardiomyopathy/heart failure are discussed. Current recommended ART and their major side effects are summarized in table format. All medical personnel must be aware of the increasing incidence of CVD on the morbidity and mortality in HIV infected patients and must be watchful for the presence of CVD in their patients with HIV.PM...
Source: Atherosclerosis - May 22, 2023 Category: Cardiology Authors: Robert J Henning John N Greene Source Type: research
Association of Interleukin-6 and Interleukin-18 with Cardiovascular Disease in Older Adults: Atherosclerosis Risk in Communities Study
CONCLUSION: Among older adults, both IL-6 and IL-18 were associated with global CVD and death. The association between IL-6 with CVD appears to be more robust and was independent of hs-CRP, NT-proBNP, and hs-TnT.PMID:37306504 | DOI:10.1093/eurjpc/zwad197
Source: Atherosclerosis - June 12, 2023 Category: Cardiology Authors: Xiaoming Jia Leo Buckley Caroline Sun Mahmoud Al Rifai Bing Yu Vijay Nambi Salim S Virani Elizabeth Selvin Kunihiro Matsushita Ron C Hoogeveen Josef Coresh Amil M Shah Christie M Ballantyne Source Type: research
Assessing statins use in a real-world primary care digital strategy: a cross-sectional analysis of a population-wide digital health approach
Lancet Reg Health Am. 2023 Jun 22;23:100534. doi: 10.1016/j.lana.2023.100534. eCollection 2023 Jul.ABSTRACTBACKGROUND: The digitization of the primary care system provides an opportunity to evaluate the current use of statins in secondary prevention populations (myocardial infarction or stroke).METHODS: We conducted a cross-sectional study (ClinicalTrials.gov, NCT05285085), analysing anonymised data routinely collected by community health workers (CHW) in Brazil between May 2016 and September 2021 to assess the proportion of self-reported statins use and associated factors.FINDINGS: From the 2,133,900 individuals on the da...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: M Julia Machline-Carrion Alysson Nathan Girotto Josu é Nieri Pedro Marton Pereira Frederico Monfardini Francisco Forestiero Priscila Raupp Fabiana Roveda Karla Santo Ot ávio Berwanger Raul D Santos Source Type: research
Anti-inflammatory therapies were associated with reduced risk of myocardial infarction in patients with established cardiovascular disease or high cardiovascular risks: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Anti-inflammatory therapies, especially those targeting the central IL-6 signaling pathway, may serve as promising treating strategies to ameliorate the risk of MI. IL-1 inhibitor and colchicine were associated with decreased risks of heart failure and stroke, respectively. MI risk reduction by anti-inflammatory therapies seemed to be more prominent in older patients with long follow-up duration.PMID:37527612 | DOI:10.1016/j.atherosclerosis.2023.06.972
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: Zonglin Li Chu Lin Xiaoling Cai Suiyuan Hu Fang Lv Wenjia Yang Xingyun Zhu Linong Ji Source Type: research
