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Source: International Journal of Cardiology
Condition: Heart Failure
Drug: Fentanyl
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Group III/IV muscle afferents impair limb blood in patients with chronic heart failure
Abstract: Objective: To better understand the hemodynamic and autonomic reflex abnormalities in heart-failure patients (HF), we investigated the influence of group III/IV muscle afferents on their cardiovascular response to rhythmic exercise.Methods: Nine HF-patients (NYHA class-II, mean left ventricular ejection-fraction: 27±3%) performed single leg knee-extensor exercise (25/50/80% peak-workload) under control conditions and with lumbar intrathecal fentanyl impairing μ-opioid receptor-sensitive muscle afferents.Results: Cardiac-output (Q) and femoral blood-flow (QL) were determined, and arterial/venous blood samples co...
Source: International Journal of Cardiology - May 5, 2014 Category: Cardiology Authors: Markus Amann, Massimo Venturelli, Stephen J. Ives, David E. Morgan, Benjamin Gmelch, Melissa A.H. Witman, H. Jonathan Groot, D. Walter Wray, Josef Stehlik, Russell S. Richardson Tags: Original Articles Source Type: research
