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Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Ying Yang 1 engagement in brain pathology
AbstractHerein, we discuss data concerning the involvement of transcription factor Yin Yang 1 (YY1) in the development of brain diseases, highlighting mechanisms of its pathological actions. YY1 plays an important role in the developmental and adult pathology of the nervous system. YY1 is essential for neurulation as well as maintenance and differentiation of neuronal progenitor cells and oligodendrocytes regulating both neural and glial tissues of the brain. Lack of a YY1 gene causes many developmental abnormalities and anatomical malformations of the central nervous system (CNS). Once dysregulated, YY1 exerts multiple ne...
Source: Journal of Neurochemistry - February 24, 2022 Category: Neuroscience Authors: Sylwia Pabian ‐Jewuła, Aneta Bragiel‐Pieczonka, Marcin Rylski Tags: SYSTEMATIC REVIEW Source Type: research

Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation
AbstractBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor ‐independent mechanism by reversing the reaction catalysed by S‐adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S‐adenosylmethionine (SAM)‐dependent methyltransferases. Astrocytes are essential in maintaining brain homeostasis but their pathological activa tion and uncontrolled proliferation plays a role in neurodegeneration and glioma. Adenosine can affect cell proliferatio...
Source: Journal of Neurochemistry - December 6, 2019 Category: Neuroscience Authors: Helena Marcelino, Vanda C. Nogueira, Cec ília R.A. Santos, Patrícia Quelhas, Tiago M.A. Carvalho, João Fonseca‐Gomes, Joana Tomás, Maria J. Diógenes, Ana M. Sebastião, José F. Cascalheira Tags: ORIGINAL ARTICLE Source Type: research

MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy
This article is part of the 60th Anniversary special issue. MMP‐9, through cleavage of specific target proteins, plays a major role in synaptic plasticity and neuroinflammation, and by those virtues contributes to brain physiology and a host of neurological and psychiatric disorders. This article is part of the 60th Anniversary special issue.
Source: Journal of Neurochemistry - March 21, 2016 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Bench to Bedside Source Type: research

MMP ‐9 in translation: from molecule to brain physiology, pathology, and therapy
This article is part of the 60th Anniversary special issue. MMP‐9, through cleavage of specific target proteins, plays a major role in synaptic plasticity and neuroinflammation, and by those virtues contributes to brain physiology and a host of neurological and psychiatric disorders. This article is part of the 60th Anniversary special issue.
Source: Journal of Neurochemistry - March 20, 2016 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Bench to Bedside Source Type: research

MMP‐9 in Translation: From Molecule to Brain Physiology, Pathology and Therapy
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 3, 2015 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Review Source Type: research