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Condition: Brain Tumor
Drug: Namenda
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Total 3 results found since Jan 2013.
Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones
Publication date: Available online 13 October 2017 Source:Nitric Oxide Author(s): Meric A. Altinoz, İlhan Elmaci Glioblastoma multiforme (GBM) is a devastating brain cancer with no curative treatment. Targeting Nitric Oxide (NO) and glutamatergic pathways may help as adjunctive treatments in GBM. NO at low doses promotes tumorigenesis, while at higher levels (above 300 nM) triggers apoptosis. Gliomas actively secrete high amounts of glutamate which activates EGR signaling and mediates degradation of peritumoral tissues via excitotoxic injury. Memantine inhibits NMDA-subtype of glutamate receptors (NMDARs) and induces au...
Source: Nitric Oxide - October 13, 2017 Category: Chemistry Source Type: research
