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The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.
Conclusions: Taken together, these results provide evidence that SMC-derived cells within advanced mouse and human atherosclerotic lesions exhibit far greater phenotypic plasticity than generally believed, with Klf4 regulating transition to multiple phenotypes including Lgals3+ osteogenic cells likely to be detrimental for late stage atherosclerosis plaque pathogenesis. PMID: 32674599 [PubMed - as supplied by publisher]
Source: Circulation - July 16, 2020 Category: Cardiology Authors: Alencar GF, Owsiany KM, K S, Sukhavasi K, Mocci G, Nguyen A, Williams CM, Shamsuzzaman S, Mokry M, Henderson CA, Haskins R, Baylis RA, Finn AV, McNamara CA, Zunder ER, Venkata V, Pasterkamp G, Björkegren J, Bekiranov S, Owens GK Tags: Circulation Source Type: research

Carotid Stent Fractures are not Associated with Adverse Events: Results from the ACT 1 Multicenter Randomized Trial.
Conclusions -In this large, independently-adjudicated, multicenter study, the stent fracture rate was low and not associated with major adverse clinical events or in-stent restenosis. Clinical Trial Registration -URL: https://clinicaltrials.gov Unique Identifier: NCT00106938. PMID: 28982691 [PubMed - as supplied by publisher]
Source: Circulation - October 5, 2017 Category: Cardiology Authors: Weinberg I, Beckman JA, Matsumura JS, Rosenfield K, Ansel G, Chaturvedi S, Gray WA, Metzger DC, Riles TS, Shu Y, Wechsler LR, Jaff MR Tags: Circulation Source Type: research