Filtered By:
Source: Circulation
Condition: Heart Attack

This page shows you your search results in order of date. This is page number 15.

Order by Relevance | Date

Total 272 results found since Jan 2013.

Changing Cholesterol Levels and Coronary Heart Disease Risk.
Abstract A report by Colantonio and colleagues in this issue of Circulation describes the relations between serum lipoprotein cholesterol levels and triglycerides with coronary heart disease (CHD) incidence.(1) Their analyses draw upon the experience of three American population samples of adults with 8.9 years of follow up. The first study group is the Reasons for Geographic and Racial Differences in Stroke (REGARDS, National Institutes of Health observational cohort, baseline 2003-2007), the second investigation is the Atherosclerosis Risk in Communities (ARIC, National Heart, Lung and Blood observational cohort...
Source: Circulation - December 9, 2015 Category: Cardiology Authors: Wilson PW Tags: Circulation Source Type: research

Stroke in Adults With Congenital Heart Disease: Incidence, Cumulative Risk and Predictors.
CONCLUSIONS: -Among ACHD-patients, one in eleven men and one in fifteen women suffered a stroke between age 18 and 64. Stroke-incidence was considerably higher than in the general population, especially at younger age. The most important predictors of ischemic stroke were heart failure, diabetes and recent myocardial infarction. Further research is required to see if advances in the management of ACHD may reduce this substantial stroke rate. PMID: 26597113 [PubMed - as supplied by publisher]
Source: Circulation - November 23, 2015 Category: Cardiology Authors: Lanz J, Brophy JM, Therrien J, Kaouache M, Guo L, Marelli AJ Tags: Circulation Source Type: research

Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults: The Cardiovascular Health Study.
CONCLUSIONS: -These data provide empiric suggestion supporting PA recommendations, in particular walking, to reduce incidence of CVD among older adults. PMID: 26538582 [PubMed - as supplied by publisher]
Source: Circulation - November 4, 2015 Category: Cardiology Authors: Soares-Miranda L, Siscovick DS, Psaty BM, Longstreth WT, Mozaffarian D Tags: Circulation Source Type: research

The Study of Cardiovascular Health Outcomes in the Era of Claims Data: The Cardiovascular Health Study.
CONCLUSIONS: -The use of diagnostic codes from claims data as clinical events, especially when restricted to primary diagnoses, leads to an underestimation of event rates. Additionally, claims-based events data represent a composite endpoint that includes the outcome of interest and selected (misclassified) non-event hospitalizations. PMID: 26538580 [PubMed - as supplied by publisher]
Source: Circulation - November 4, 2015 Category: Cardiology Authors: Psaty BM, Delaney JA, Arnold AM, Curtis LH, Fitzpatrick AL, Heckbert SR, McKnight B, Ives D, Gottdiener JS, Kuller LH, Longstreth WT Tags: Circulation Source Type: research

Influence of Gender on Long-Term Outcomes After Implantation of Bare-Metal Stent: A Multicenter Report From the Coronary Revascularization Demonstrating Outcome Study-Kyoto (CREDO-Kyoto) Registry Cohort-1.
CONCLUSIONS: -TLR and ST continued to occur without attenuation up to 10-year after BMS implantation. Men as compared with women were associated with higher adjusted 10-year risks for all-cause death, MI, stroke, CABG, TLR, and non-TLR. PMID: 26443611 [PubMed - as supplied by publisher]
Source: Circulation - October 6, 2015 Category: Cardiology Authors: Yamaji K, Shiomi H, Morimoto T, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Kato M, Takatsu Y, Doi O, Kambara H, Suwa S, Onodera T, Watanabe H, Natsuaki M, Kimura T Tags: Circulation Source Type: research

The Efficacy and Safety of Vorapaxar With and Without a Thienopyridine for Secondary Prevention in Patients with Prior Myocardial Infarction and no History of Stroke or TIA: Results from TRA 2°P-TIMI 50.
CONCLUSIONS: -Vorapaxar reduced cardiovascular death, MI, or stroke in stable patients with a history of prior MI, whether treated concomitantly with a thienopyridine or not. The relative risk of moderate or severe bleeding was similarly increased irrespective of thienopyridine use. Clinical Trial Registration Information-http://www.clinicaltrials.gov. Identifier: NCT00526474. PMID: 26338971 [PubMed - as supplied by publisher]
Source: Circulation - September 3, 2015 Category: Cardiology Authors: Bohula EA, Aylward PE, Bonaca MP, Corbalan RL, Kiss RG, Murphy SA, Scirica BM, White H, Braunwald E, Morrow DA Tags: Circulation Source Type: research

How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People.
CONCLUSIONS: -The majority of initial presentations of CVD are neither MI nor ischemic stroke, yet most primary prevention studies focus on these presentations. Sex has differing associations with different CVDs, with implications for risk prediction and management strategies. Clinical Trial Registration Information-www.clinicaltrials.gov. Identifier: NCT01164371. PMID: 26330414 [PubMed - as supplied by publisher]
Source: Circulation - September 1, 2015 Category: Cardiology Authors: George J, Rapsomaniki E, Pujades-Rodriguez M, Shah AD, Denaxas S, Herrett E, Smeeth L, Timmis A, Hemingway H Tags: Circulation Source Type: research

Procoagulant Platelets: Not Just Full of Hot Air.
Abstract Abnormalities in coagulation are a leading cause of disease and death worldwide due to thrombotic events such as myocardial infarction, stroke, etc. It has been estimated that the cost of treatment of these disorders will rise to over 820 billion by the year 2030.(1) At the center of thrombus formation is the platelet, a cell that is seen as the cornerstone of hemostasis and thrombosis. Platelets mainly function to secure hemostasis by acting as the "band-aids of the blood". They are the first responders to sites of vascular injury, bringing with them a membrane surface that provides the "glue" for clot f...
Source: Circulation - September 1, 2015 Category: Cardiology Authors: Battinelli EM Tags: Circulation Source Type: research

A Conductive Polymer Hydrogel Supports Cell Electrical Signaling and Improves Cardiac Function After Implantation into Myocardial Infarct.
CONCLUSIONS: We synthesized a biocompatible conductive biomaterial (PPy-chitosan) that enhances biological conduction in vitro and in vivo. Injection of PPy-chitosan better maintained heart function after myocardial infarction than a nonconductive polymer. PMID: 26304669 [PubMed - in process]
Source: Circulation - August 25, 2015 Category: Cardiology Authors: Mihic A, Cui Z, Wu J, Vlacic G, Miyagi Y, Li SH, Lu S, Sung HW, Weisel RD, Li RK Tags: Circulation Source Type: research

Southern Dietary Pattern is Associated with Hazard of Acute Coronary Heart Disease in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
CONCLUSIONS: -A dietary pattern characteristic of the southern US was associated with greater hazard of CHD in this sample of white and black adults in diverse regions of the US. PMID: 26260732 [PubMed - as supplied by publisher]
Source: Circulation - August 10, 2015 Category: Cardiology Authors: Shikany JM, Safford MM, Newby PK, Durant RW, Brown TM, Judd SE Tags: Circulation Source Type: research

A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
Abstract Alterations in lipid metabolism and inflammatory processes are well established as potential risk factors in the development and progression of cardiovascular disease.(1) However, with complications ranging from valve dysfunction to arrhythmia to myocardial infarction and stroke, the underlying mechanisms may be as varied as cardiovascular disease itself. On the other hand, the reoccurrence of common molecular and cellular pathways identified in the collective body of cardiovascular research could suggest shared initiators or mechanistic nodes between seemingly divergent processes, including lipid metabol...
Source: Circulation - July 29, 2015 Category: Cardiology Authors: Rogers MA, Aikawa E Tags: Circulation Source Type: research

Utility of Non-Traditional Risk Markers in Individuals Ineligible for Statin Therapy According to the 2013 ACC/AHA Cholesterol Guidelines.
CONCLUSIONS: -In this generally low-risk population sample, a large proportion of ASCVD events occurred among adults with a 10-yr. cPCE risk <7.5%. We found that the CAC, hsCRP, FH and ABI recommendations by the ACC/AHA cholesterol guidelines (Class IIB) identify small subgroups of asymptomatic population with <7.5% 10 yr. cPCE but with observed ASCVD event rates higher than 7.5% who may warrant statin therapy considerations. PMID: 26224808 [PubMed - as supplied by publisher]
Source: Circulation - July 29, 2015 Category: Cardiology Authors: Yeboah J, Polonsky TS, Young R, McClelland RL, Delaney JC, Dawood F, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC, Psaty BM, Greenland P, Herrington DM Tags: Circulation Source Type: research

The Power of the Cluster.
Abstract The past 50 years have witnessed sea changes in cardiovascular medicine and research.(1) We came to recognize untreated hypertension as a highly malignant disorder and to recognize that medical treatment of hypertension leads to marked reductions in risk of stroke, myocardial infarction, and premature death. We also came to recognize the power of the randomized trial for assessing candidate strategies for prevention and treatment. Indeed, mega-trials conducted by cardiovascular clinician scientists have played a critical role in defining nearly every major evidence-based intervention, from hypertension tr...
Source: Circulation - July 17, 2015 Category: Cardiology Authors: Lauer MS, Mensah GA Tags: Circulation Source Type: research

Percutaneous Coronary Intervention at Centers With and Without On-Site Surgical Backup: An Updated Meta-Analysis of 23 Studies.
CONCLUSIONS: -Clinical outcomes and complication rates of PCI at centers without on-site surgery did not differ from those with on-site surgery, for both primary and non-primary PCI. Temporal trends indicated improving clinical outcomes in non-primary PCI at centers without on-site surgery. PMID: 26152708 [PubMed - as supplied by publisher]
Source: Circulation - July 7, 2015 Category: Cardiology Authors: Lee JM, Hwang D, Park J, Kim KJ, Ahn C, Koo BK Tags: Circulation Source Type: research

Yes, We Can! (Should We?).
Abstract Historically, percutaneous coronary intervention (PCI) was relegated to hospitals with co-located cardiac surgery because of the potential need for emergent surgical treatment of PCI-related complications. In the current issue of Circulation, Lee and colleagues(1) compare outcomes of PCI at hospitals with and without on-site cardiac surgery and show that emergency cardiac surgery is, in fact, rarely needed (<1%). This meta-analysis summarizes 23 studies that include over one million patients and demonstrates the incidence of other PCI-related complications including myocardial infarction, stroke, cardi...
Source: Circulation - July 7, 2015 Category: Cardiology Authors: Aversano TR Tags: Circulation Source Type: research