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Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States
This study aimed to determine the association between the Danish Co-morbidity Index for Acute Myocardial Infarction (DANCAMI) and restricted DANCAMI (rDANCAMI) scores and clinical outcomes in patients hospitalized with AMI. Using the National Inpatient Sample, all AMI hospitalizations were stratified into four groups based on their DANCAMI and rDANCAMI score (0; 1 to 3; 4 to 5; ≥6). The primary outcome was all-cause mortality, whereas secondary outcomes were major adverse cardiovascular/cerebrovascular events, major bleeding, ischemic stroke, and receipt of coronary angiography or percutaneous coronary intervention.
Source: The American Journal of Cardiology - July 14, 2022 Category: Cardiology Authors: Balamrit Singh Sokhal, Andrija Mateti ć, Abhishek, Philip Freeman, Jan Walter Dhillon Shanmuganathan, Mohamed O. Mohamed, Christian Mallen, Mamas A. Mamas Source Type: research

Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Undergoing Diagnostic Coronary Angiography (From the Catheter Sampled Blood Archive in Cardiovascular Diseases CASABLANCA Study)
We sought to develop a multiple biomarker approach for prediction of incident major adverse cardiovascular events (MACE; composite of cardiovascular death, myocardial infarction and stroke) in patients referred for coronary angiography. In a 649-participant training cohort, predictors of MACE within one year were identified using least-angle regression; over fifty clinical variables and 109 biomarkers were analyzed. Predictive models were generated using LASSO with logistic regression. A score derived from the final model was developed and evaluated with a 278-patient validation set during a median of 3.6 years follow up.
Source: The American Journal of Cardiology - April 13, 2017 Category: Cardiology Authors: Cian P. McCarthy, Roland R.J. van Kimmenade, Hanna K. Gaggin, Mandy L. Simon, Nasrien E. Ibrahim, Parul Gandhi, Noreen Kelly, Shweta R. Motiwala, Arianna M. Belcher, Jamie Harisiades, Craig A. Magaret, Rhonda F. Rhyne, James L. Januzzi Source Type: research

Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Who Underwent Diagnostic Coronary Angiography (from the Catheter Sampled Blood Archive in Cardiovascular Diseases CASABLANCA Study)
We sought to develop a multiple biomarker approach for prediction of incident major adverse cardiac events (MACE; composite of cardiovascular death, myocardial infarction, and stroke) in patients referred for coronary angiography. In a 649-participant training cohort, predictors of MACE within 1 year were identified using least-angle regression; over 50 clinical variables and 109 biomarkers were analyzed. Predictive models were generated using least absolute shrinkage and selection operator with logistic regression.
Source: The American Journal of Cardiology - April 13, 2017 Category: Cardiology Authors: Cian P. McCarthy, Roland R.J. van Kimmenade, Hanna K. Gaggin, Mandy L. Simon, Nasrien E. Ibrahim, Parul Gandhi, Noreen Kelly, Shweta R. Motiwala, Arianna M. Belcher, Jamie Harisiades, Craig A. Magaret, Rhonda F. Rhyne, James L. Januzzi Tags: Coronary Artery Disease Source Type: research

Prognostic Usefulness of Serum Cholesterol Efflux Capacity in Patients with Coronary Artery Disease
Cholesterol efflux capacity has been shown to have an inverse relationship with coronary artery disease (CAD) and may overcome the limitations of high density lipoprotein cholesterol levels as a predictor for CAD risks. We investigated the predictive value of cholesterol efflux capacity for the prognosis of CAD. Serum cholesterol efflux capacity in 313 patients newly diagnosed with CAD by coronary angiography was measured, and all patients completed a 3-year follow-up. The primary clinical endpoints were non-fatal myocardial infarction, non-fatal stroke and cardiovascular mortality.
Source: The American Journal of Cardiology - December 1, 2015 Category: Cardiology Authors: Jianhua Zhang, Jia Xu, Jingfeng Wang, Changhao Wu, Yan Xu, Yueguo Wang, Fengfeng Deng, Zhe Wang, Xuhua Chen, Mengzuo Wu, Yangxin Chen Source Type: research

Effect of Gender on Patients with ST-elevation and Non-ST-elevation Myocardial Infarction without Obstructive Coronary Artery Disease
We compared the prognosis of patients with ST-elevation MI (STEMI) with non-ST-elevation MI (NSTEMI) without obstructive coronary artery disease (CAD) and the risk associated with gender for future cardiovascular (CV) events. The study population was selected from 95,849 patients undergoing coronary angiography for MI during the period 2005-2010 and registered in the Swedish Coronary Angiography and Angioplasty Registry. Outcome analyses, including all-cause death, MI, congestive heart failure (CHF), stroke and revascularization, were performed on 2268 STEMI patients and 10,904 NSTEMI patients without obstructive CAD (
Source: The American Journal of Cardiology - March 24, 2015 Category: Cardiology Authors: Nina Johnston, Birgitta Jönelid, Christina Christersson, Tanja Kero, Henrik Renlund, Karin Schenck-Gustafsson, Bo Lagerqvist Source Type: research

Impact of Multiple Complex Plaques on Short- and Long-Term Clinical Outcomes in Patients Presenting With ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction HORIZONS-AMI Trial)
It is not known whether the extent and severity of nonculprit coronary lesions correlate with outcomes in patients with ST-segment elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention (PCI). We sought to quantify complex plaques in patients with STEMI referred for primary PCI and to determine their effect on short- and long-term clinical outcomes by examining the core laboratory database for plaque analysis from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction study. Baseline demographic, angiographic, and procedural details were compared b...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Ellen C. Keeley, Roxana Mehran, Sorin J. Brener, Bernhard Witzenbichler, Giulio Guagliumi, Dariusz Dudek, Ran Kornowski, Ovidiu Dressler, Martin Fahy, Ke Xu, Cindy L. Grines, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research

Prognosis of Patients With Stable Coronary Artery Disease (from the CORONOR Study)
In conclusion, the mortality rate of patients with stable CAD in modern clinical practice is similar to that of the general population and is mostly due to noncardiovascular causes.
Source: The American Journal of Cardiology - January 15, 2014 Category: Cardiology Authors: Christophe Bauters, Michel Deneve, Olivier Tricot, Thibaud Meurice, Nicolas Lamblin, CORONOR Investigators Tags: Coronary Artery Disease Source Type: research

Association Between Intraprocedural Thrombotic Events and Adverse Outcomes After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction (a Harmonizing Outcomes With RevasculariZatiON and Stents in Acute Myocardial Infarction HORIZONS-AMI Substudy)
The present study sought to determine the extent to which adverse angiographic events encountered during percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) are associated with adverse clinical outcomes. Patients with STEMI represent a cohort at particularly high risk of intraprocedural thrombotic events (IPTEs). The overall frequency and implications of IPTEs occurring in patients with STEMI have not been systematically quantified in previous studies. A total of 3,163 patients undergoing primary percutaneous coronary intervention with stent implantation for STEMI in the Harmonizing Ou...
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Ajay J. Kirtane, Prabhdeep Sandhu, Roxana Mehran, Margaret McEntegart, Ecaterina Cristea, Sorin J. Brener, Ke Xu, Martin Fahy, Philippe Généreux, Jeffrey D. Wessler, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research

Treatment Patterns and Outcomes in Patients Undergoing Percutaneous Coronary Intervention Treated With Prasugrel or Clopidogrel (from the Swedish Coronary Angiography and Angioplasty Registry SCAAR)
In conclusion, in this real world population of patients who underwent urgent or elective PCI, prasugrel was used mainly in patients with ACS, while it was avoided in patients with characteristics indicating increased bleeding risk. Mortality and bleeding rates were lower with prasugrel than clopidogrel, probably because of patient selection.
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Peter Damman, Christoph Varenhorst, Sasha Koul, Peter Eriksson, David Erlinge, Bo Lagerqvist, Stefan K. James Tags: Coronary Artery Disease Source Type: research

Usefulness of Local Delivery of Thrombolytics Before Thrombectomy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (the Delivery of Thrombolytics Before Thrombectomy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention DISSOLUTION Randomized Trial)
In conclusion, local, intrathrombus delivery of thrombolytics before manual thrombectomy improved the postprocedural coronary flow and myocardial perfusion and the 6-month clinical outcomes.
Source: The American Journal of Cardiology - May 28, 2013 Category: Cardiology Authors: Cesare Greco, Francesco Pelliccia, Gaetano Tanzilli, Maria Denitza Tinti, Paola Salenzi, Cristina Cicerchia, Michele Schiariti, Ferdinando Franzoni, Giuseppe Speziale, Pietro Gallo, Carlo Gaudio Tags: Coronary Artery Disease Source Type: research

Effect of Cystatin C Levels on Angiographic Atherosclerosis Progression and Events Among Postmenopausal Women With Angiographically Decompensated Coronary Artery Disease (from the Women’s Angiographic Vitamin and Estrogen WAVE Study)
End-stage renal disease and mild renal insufficiency are associated with increased cardiovascular risk. Cystatin C, a novel marker of kidney function, was found to be associated with a higher frequency of cardiovascular events and mortality independent of glomerular filtration rate. It remained uncertain, however, whether enhanced cardiovascular risk associated with cystatin C is due to accelerated progression of atherosclerosis or to plaque instability. The aim of this study was to examine the effects of baseline cystatin C on annual change in coronary artery narrowing and clinical events in 423 postmenopausal women with ...
Source: The American Journal of Cardiology - March 18, 2013 Category: Cardiology Authors: Dhavalkumar Patel, Soha Ahmad, Angela Silverman, Joseph Lindsay Tags: Coronary Artery Disease Source Type: research

Usefulness of Cardiac Biomarker Score for Risk Stratification in Stable Patients Undergoing Elective Cardiac Evaluation Across Glycemic Status
Several clinically available cardiac biomarkers have established their prognostic value in patients with acute coronary syndromes. However, their relative prognostic significance in stable subjects has not been prospectively validated, either individually or in combination. The aim of this study was to evaluate the extent to which B-type natriuretic peptide, myeloperoxidase, and high-sensitivity C-reactive protein alone or together could be prognostic biomarkers in 3,635 consecutive stable patients without acute coronary syndrome who underwent elective diagnostic coronary angiography. After adjusting for traditional risk f...
Source: The American Journal of Cardiology - December 7, 2012 Category: Cardiology Authors: W.H. Wilson Tang, Naveed Iqbal, Yuping Wu, Stanley L. Hazen Tags: Coronary Artery Disease Source Type: research