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Source: Atherosclerosis
Condition: Heart Attack

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Total 556 results found since Jan 2013.

Early postoperative outcome after carotid artery endarterectomy with bifurcation advancement
Conclusions: CEA with bifurcation advancement provides comparable perioperative results, focusing on combined stroke and mortality, but seems to have some technical drawbacks, which may lead to more frequent local neurological complications.PMID:37170543 | DOI:10.1024/0301-1526/a001074
Source: Atherosclerosis - May 12, 2023 Category: Cardiology Authors: Felix L Moehle Bernard Krueger Anna-Leonie Menges Zoran Rancic Alexander Zimmermann Source Type: research

Efficacy and safety of the use of alirocumab in real clinical practice
CONCLUSION: The inclusion of alirocumab in the treatment regimen contributed to the stable course of atherosclerosis-associated diseases, the achievement of LDL cholesterol targets in 77.8% of patients, was not accompanied by side effects during 2.5 years therapy.PMID:37167185 | DOI:10.26442/00403660.2022.12.201991
Source: Atherosclerosis - May 11, 2023 Category: Cardiology Authors: V A Korneva T Y Kuznetsova I S Scopets N N Vezikova Source Type: research

Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Atherosclerosis - May 11, 2023 Category: Cardiology Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research

Lesion-specific suppression of YAP/TAZ by biomimetic nanodrug ameliorates atherosclerosis development
bioRxiv. 2023 Apr 26:2023.04.24.537992. doi: 10.1101/2023.04.24.537992. Preprint.ABSTRACTAtherosclerosis, characterized by the buildup of lipid-rich plaque on the vessel wall, is the primary cause of myocardial infarction and ischemic stroke. Recent studies have demonstrated that dysregulation of yes-associated protein 1 (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) contributes to plaque development, making YAP/TAZ potential therapeutic targets. However, systemic modulation of YAP/TAZ expression or activities risks serious off-target effects, limiting clinical applicability. To address the challenge, ...
Source: Atherosclerosis - May 10, 2023 Category: Cardiology Authors: Hui-Chun Huang Ting-Yun Wang Joshua Rousseau Michelle Mungaray Chamonix Michaud Christopher Plaisier Zhen Bouman Chen Kuei-Chun Wang Source Type: research

Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis
PLoS One. 2023 May 10;18(5):e0285253. doi: 10.1371/journal.pone.0285253. eCollection 2023.ABSTRACTAtherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is sensitive to changes in shear stress. Here, using atheroprone, ApoE-/- mice, with a single allele deletion of Arf6 (HET) or wildtype Arf6 (WT), we demonstrate that reduction in Arf6 attenuates atherosclerotic plaque burden and severity. We found that plaque burden in the descending...
Source: Atherosclerosis - May 10, 2023 Category: Cardiology Authors: Venkateswara R Gogulamudi Md Torikul Islam Jessica R Durrant Adelola O Adeyemo Daniel W Trott Mi Ho Hyuhn Weiquan Zhu Anthony J Donato Ashley E Walker Lisa A Lesniewski Source Type: research

Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy
Biomed Pharmacother. 2023 May 2;163:114817. doi: 10.1016/j.biopha.2023.114817. Online ahead of print.ABSTRACTCardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusio...
Source: Atherosclerosis - May 4, 2023 Category: Cardiology Authors: Yanhong Pan Weipeng Wu Xiaoxin Jiang Yunhong Liu Source Type: research

Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes
CONCLUSIONS: In patients undergoing coronary angiography, Lp(a) and OxPL-apoB are associated with multivessel CAD. Lp(a), OxPL-apoB, and OxPL-apo(a) are associated with incident cardiovascular events. (Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA]; NCT00842868).PMID:37137588 | DOI:10.1016/j.jacc.2023.02.050
Source: Atherosclerosis - May 3, 2023 Category: Cardiology Authors: Thomas C Gilliland Yuxi Liu Reza Mohebi Hannah Miksenas Sara Haidermota Megan Wong Xingdi Hu Joaquim Rosado Cristino Auris Browne Jorge Plutzky Sotirios Tsimikas James L Januzzi Pradeep Natarajan Source Type: research

Association Between Major Adverse Cardiovascular Events and the Gensini Score or Coronary Artery Calcification Score in Hypertensive Patients Who Have Undergone Coronary Computed Tomography Angiography
CONCLUSIONS: The CAC score and the Gensini score could predict MACEs in hypertensive patients who have undergone CCTA.PMID:37091887 | PMC:PMC10116937 | DOI:10.14740/cr1453
Source: Atherosclerosis - April 24, 2023 Category: Cardiology Authors: Yuhei Shiga Kohei Tashiro Erica Miura Sara Higashi Yuto Kawahira Takashi Kuwano Makoto Sugihara Shin-Ichiro Miura Source Type: research

How much does hypertension in pregnancy affect the risk of future cardiovascular events?
Eur Heart J Suppl. 2023 Apr 21;25(Suppl B):B111-B113. doi: 10.1093/eurheartjsupp/suad085. eCollection 2023 Apr.ABSTRACTHypertensive disorders in pregnancy (HDP) include essential (or secondary) hypertension occurring before 20 weeks of gestation or in women already on antihypertensive therapy prior to pregnancy, gestational hypertension, developing after 20 weeks of gestation without significant proteinuria, and pre-eclampsia or AH onset after 20 weeks of pregnancy in the presence of proteinuria. The development of HDP is associated with a higher incidence of long-term cardiovascular (CV) adverse events, such as myocardial...
Source: Atherosclerosis - April 24, 2023 Category: Cardiology Authors: Gian Francesco Mureddu Source Type: research

For Your Eyes Only: 007 Tips for the Management of Cardiovascular Risk Factors in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
J Rheumatol. 2023 Apr 15:jrheum.2023-0219. doi: 10.3899/jrheum.2023-0219. Online ahead of print.ABSTRACTPremature atherosclerosis has been observed during the course of different systemic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).1-3 As a result, cardiovascular (CV) events, including myocardial infarction, stroke, heart failure, coronary artery disease, and death, occur 1.65 to 3 times more commonly in patients with AAV as compared to the general population, and the risk appears to be highest in the firs...
Source: Atherosclerosis - April 15, 2023 Category: Cardiology Authors: Jan Willem Cohen Tervaert Source Type: research

Association between complete revascularization of the coronary artery and clinical outcomes in peripheral artery disease: a sub-analysis of the I-PAD Nagano registry
This study was based on a prospective, multicenter, observational registry in Japan. We enrolled 366 patients with PAD undergoing endovascular treatment. The primary endpoint was MACE, defined as a composite of all-cause death, non-fatal myocardial infarction, and non-fatal stroke. After excluding ineligible patients, 96 and 68 patients received complete revascularization of the coronary artery (CR group) and incomplete revascularization of the coronary artery (ICR group), respectively. Freedom from MACE in the CR group was significantly higher than in the ICR group at 5 years (66.7% vs 46.0%, p < 0.01). Multivariate an...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Tamon Kato Yasushi Ueki Masatoshi Minamisawa Takashi Miura Yushi Oyama Naoto Hashizume Daisuke Yokota Minami Taki Keisuke Senda Yoshiteru Okina Tadamasa Wakabayashi Koki Fujimori Kenichi Karube Takahiro Sakai Hidetomo Nomi Hisanori Yui Yusuke Kanzaki Keis Source Type: research

Inflammation Beats Cholesterol: A Comment on the Unequivocal Driver of Cardiovascular Disease Risk
J Clin Med. 2023 Mar 27;12(7):2519. doi: 10.3390/jcm12072519.ABSTRACTDespite advancements in the current standard of care, cardiovascular diseases continue to hold the top spot as the leading cause of mortality worldwide. The development of atherosclerosis is the most common culprit behind ailments such as myocardial infarction, stroke, and peripheral vascular disease. Consequently, it imposes a significant burden on life expectancy, quality of life, morbidity, and societal costs. Both increased cholesterol levels and the activation of the inflammatory cascade are known as cardiovascular risk facts. Their relative weight i...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Mauro Vaccarezza Francesco Maria Galassi Source Type: research

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